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  1. Research

    Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes

    Excitation/inhibition (E/I) imbalance remains a widely discussed hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may potentially define a therapeutic target for the treatment o...

    Joana Gonçalves, Inês R. Violante, José Sereno, Ricardo A. Leitão, Ying Cai, Antero Abrunhosa, Ana Paula Silva, Alcino J. Silva and Miguel Castelo-Branco

    Molecular Autism 2017 8:47

    Published on: 19 September 2017

  2. Research

    Prenatal levonorgestrel exposure induces autism-like behavior in offspring through ERβ suppression in the amygdala

    Autism spectrum disorder (ASD) is characterized by impairments in social communication and restricted or repetitive behaviors or interests. ASD is now diagnosed in more than one out of 100 children and is bias...

    Yuanlin Zou, Qiaomei Lu, Dan Zheng, Zhigang Chu, Zhaoyu Liu, Haijia Chen, Qiongfang Ruan, Xiaohu Ge, Ziyun Zhang, Xiaoyan Wang, Wenting Lou, Yongjian Huang, Yifei Wang, Xiaodong Huang, Zhengxiang Liu, Weiguo Xie…

    Molecular Autism 2017 8:46

    Published on: 17 August 2017

  3. Short report

    Attitudes toward risk and ambiguity in patients with autism spectrum disorder

    Although the ability to make optimal decisions under uncertainty is an integral part of everyday life, individuals with autism spectrum disorder (ASD) frequently report that they experience difficulties with t...

    Junya Fujino, Shisei Tei, Ryu-ichiro Hashimoto, Takashi Itahashi, Haruhisa Ohta, Chieko Kanai, Rieko Okada, Manabu Kubota, Motoaki Nakamura, Nobumasa Kato and Hidehiko Takahashi

    Molecular Autism 2017 8:45

    Published on: 16 August 2017

  4. Research

    Replicative genetic association study between functional polymorphisms in AVPR1A and social behavior scales of autism spectrum disorder in the Korean population

    Arginine vasopressin has been shown to affect social and emotional behaviors, which is mediated by the arginine vasopressin receptor (AVPR1A). Genetic polymorphisms in the AVPR1A promoter region have been identif...

    So Young Yang, Soon Ae Kim, Gang Min Hur, Mira Park, Jong-Eun Park and Hee Jeong Yoo

    Molecular Autism 2017 8:44

    Published on: 9 August 2017

  5. Research

    Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally

    The amygdala controls socioemotional behavior and has consistently been implicated in the etiology of autism spectrum disorder (ASD). Precocious amygdala development is commonly reported in ASD youth with the ...

    Catherine E. Barrett, Thomas M. Hennessey, Katelyn M. Gordon, Steve J. Ryan, Morgan L. McNair, Kerry J. Ressler and Donald G. Rainnie

    Molecular Autism 2017 8:42

    Published on: 1 August 2017

  6. Research

    Balanced bifrontal transcranial direct current stimulation enhances working memory in adults with high-functioning autism: a sham-controlled crossover study

    Working memory (WM) often is impaired in autism spectrum disorder (ASD). Such impairment may underlie core deficits in cognition and social functioning. Transcranial direct current stimulation (tDCS) has been ...

    J. Jason van Steenburgh, Mark Varvaris, David J. Schretlen, Tracy D. Vannorsdall and Barry Gordon

    Molecular Autism 2017 8:40

    Published on: 28 July 2017

  7. Research

    Globally weaker and topologically different: resting-state connectivity in youth with autism

    There is a lack of agreement about functional connectivity differences in individuals with autism spectrum disorder (ASD). Studies using absolute strength have found reduced connectivity, while those using rel...

    Benjamin E. Yerys, John D. Herrington, Theodore D. Satterthwaite, Lisa Guy, Robert T. Schultz and Danielle S. Bassett

    Molecular Autism 2017 8:39

    Published on: 26 July 2017

  8. Research

    ADHD-related symptoms and attention profiles in the unaffected siblings of probands with autism spectrum disorder: focus on the subtypes of autism and Asperger’s disorder

    The presence of attention-deficit/hyperactive disorder (ADHD) symptoms and impaired attention performance are commonly noted in individuals with autism spectrum disorder (ASD). However, little is known about a...

    Yi-Ling Chien, Miao-Chun Chou, Yen-Nan Chiu, Wen-Jiun Chou, Yu-Yu Wu, Wen-Che Tsai and Susan Shur-Fen Gau

    Molecular Autism 2017 8:37

    Published on: 25 July 2017

  9. Short report

    Interrelationship between insistence on sameness, effortful control and anxiety in adolescents and young adults with autism spectrum disorder (ASD)

    Both self-regulation and insistence on sameness (IS) are related to anxiety, which is a common feature of individuals with autism spectrum disorder (ASD). Here, we aimed to characterise the IS-self-regulation-...

    Mirko Uljarević, Amanda L. Richdale, David W. Evans, Ru Ying Cai and Susan R. Leekam

    Molecular Autism 2017 8:36

    Published on: 21 July 2017

  10. Review

    Bio-collections in autism research

    Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders with diverse clinical manifestations and symptoms. In the last 10 years, there have been significant advances in understanding ...

    Jamie Reilly, Louise Gallagher, June L. Chen, Geraldine Leader and Sanbing Shen

    Molecular Autism 2017 8:34

    Published on: 10 July 2017

  11. Research article

    Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain

    MicroRNAs, small non-coding RNAs, are highly expressed in the mammalian brain, and the dysregulation of microRNA levels may be involved in neurodevelopmental disorders such as autism spectrum disorder (ASD). I...

    Yuta Hara, Yukio Ago, Erika Takano, Shigeru Hasebe, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda and Kazuhiro Takuma

    Molecular Autism 2017 8:33

    Published on: 28 June 2017

  12. Research

    Use of clinical chromosomal microarray in Chinese patients with autism spectrum disorder—implications of a copy number variation involving DPP10

    Array comparative genomic hybridization (aCGH) is recommended as a first-tier genetic test for children with autism spectrum disorder (ASD). However, interpretation of results can often be challenging partly d...

    Annisa Shui Lam Mak, Annie Ting Gee Chiu, Gordon Ka Chun Leung, Christopher Chun Yu Mak, Yoyo Wing Yiu Chu, Gary Tsz Kin Mok, Wing Fai Tang, Kelvin Yuen Kwong Chan, Mary Hoi Yin Tang, Elizabeth Tak-Kwong Lau Yim, Kin Wai So, Victoria Qinchen Tao, Cheuk Wing Fung, Virginia Chun Nei Wong, Mohammed Uddin, So Lun Lee…

    Molecular Autism 2017 8:31

    Published on: 26 June 2017

  13. Research

    Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes

    Rett syndrome (RTT) is a neurodevelopmental disorder that predominantly affects girls. The majority of RTT cases are caused by de novo mutations in methyl-CpG-binding protein 2 (MECP2), and several mouse model...

    Rylan Allemang-Grand, Jacob Ellegood, Leigh Spencer Noakes, Julie Ruston, Monica Justice, Brian J. Nieman and Jason P. Lerch

    Molecular Autism 2017 8:32

    Published on: 26 June 2017

  14. Research

    The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders

    The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particu...

    Eva Loth, Tony Charman, Luke Mason, Julian Tillmann, Emily J. H. Jones, Caroline Wooldridge, Jumana Ahmad, Bonnie Auyeung, Claudia Brogna, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Michael Brammer, Daniel Brandeis…

    Molecular Autism 2017 8:24

    Published on: 23 June 2017

  15. Research

    Effects of a social stimulus on gene expression in a mouse model of fragile X syndrome

    People with fragile X syndrome (FXS) often have deficits in social behavior, and a substantial portion meet criteria for autism spectrum disorder. Though the genetic cause of FXS is known to be due to the sile...

    Tiffany D. Rogers, Allison M. J. Anacker, Travis M. Kerr, C. Gunnar Forsberg, Jing Wang, Bing Zhang and Jeremy Veenstra-VanderWeele

    Molecular Autism 2017 8:30

    Published on: 23 June 2017

  16. Research

    The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation

    The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes...

    Tony Charman, Eva Loth, Julian Tillmann, Daisy Crawley, Caroline Wooldridge, David Goyard, Jumana Ahmad, Bonnie Auyeung, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours…

    Molecular Autism 2017 8:27

    Published on: 23 June 2017

  17. Research

    Hierarchical cortical transcriptome disorganization in autism

    Autism spectrum disorders (ASD) are etiologically heterogeneous and complex. Functional genomics work has begun to identify a diverse array of dysregulated transcriptomic programs (e.g., synaptic, immune, cell...

    Michael V. Lombardo, Eric Courchesne, Nathan E. Lewis and Tiziano Pramparo

    Molecular Autism 2017 8:29

    Published on: 21 June 2017

  18. Research

    Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

    Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral abnormalities. No treatments are approved for the core diagno...

    Sameer C. Dhamne, Jill L. Silverman, Chloe E. Super, Stephen H. T. Lammers, Mustafa Q. Hameed, Meera E. Modi, Nycole A. Copping, Michael C. Pride, Daniel G. Smith, Alexander Rotenberg, Jacqueline N. Crawley and Mustafa Sahin

    Molecular Autism 2017 8:26

    Published on: 15 June 2017

  19. Research

    Intrainsular connectivity and somatosensory responsiveness in young children with ASD

    The human somatosensory system comprises dissociable paths for discriminative and affective touch, reflected in separate peripheral afferent populations and distinct cortical targets. Differences in behavioral...

    Michelle D. Failla, Brittany R. Peters, Haleh Karbasforoushan, Jennifer H. Foss-Feig, Kimberly B. Schauder, Brynna H. Heflin and Carissa J. Cascio

    Molecular Autism 2017 8:25

    Published on: 13 June 2017

  20. Research

    Autistic traits affect interpersonal motor coordination by modulating strategic use of role-based behavior

    Despite the fact that deficits in social communication and interaction are at the core of Autism Spectrum Conditions (ASC), no study has yet tested individuals on a continuum from neurotypical development to a...

    Arianna Curioni, Ilaria Minio-Paluello, Lucia Maria Sacheli, Matteo Candidi and Salvatore Maria Aglioti

    Molecular Autism 2017 8:23

    Published on: 9 June 2017

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