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  1. The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients. ASD prevalence is higher in...

    Authors: Simona Scheggi, Francesca Guzzi, Giulia Braccagni, Maria Graziella De Montis, Marco Parenti and Carla Gambarana

    Citation: Molecular Autism 2020 11:62

    Content type: Research

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  2. The new coronavirus disease (COVID-19) pandemic is changing how society operates. Environmental changes, disrupted routines, and reduced access to services and social networks will have a unique impact on auti...

    Authors: Stephanie H. Ameis, Meng-Chuan Lai, Benoit H. Mulsant and Peter Szatmari

    Citation: Molecular Autism 2020 11:61

    Content type: Commentary

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  3. There is growing recognition that autistic females present with more diverse gender and sexual identities than their non-autistic counterparts. Likewise, autistic females are also at an increased risk of adver...

    Authors: Laura A. Pecora, Grace I. Hancock, Merrilyn Hooley, David H. Demmer, Tony Attwood, Gary B. Mesibov and Mark A. Stokes

    Citation: Molecular Autism 2020 11:57

    Content type: Research

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  4. Auditory steady state responses (ASSRs) are elicited by clicktrains or amplitude-modulated tones, which entrain auditory cortex at their specific modulation rate. Previous research has reported reductions in A...

    Authors: R. A. Seymour, G. Rippon, G. Gooding-Williams, P. F. Sowman and K. Kessler

    Citation: Molecular Autism 2020 11:56

    Content type: Research

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  5. Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia. The potential mechanisms conferring this risk are poorly understood. Here, we show tha...

    Authors: Axel Krug, Markus Wöhr, Dominik Seffer, Henrike Rippberger, A. Özge Sungur, Bruno Dietsche, Frederike Stein, Sugirthan Sivalingam, Andreas J. Forstner, Stephanie H. Witt, Helene Dukal, Fabian Streit, Anna Maaser, Stefanie Heilmann-Heimbach, Till F. M. Andlauer, Stefan Herms…

    Citation: Molecular Autism 2020 11:54

    Content type: Research

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  6. Phelan-McDermid syndrome (PMS) is a rare genetic disorder with high risk of autism spectrum disorder (ASD), intellectual disability, and language delay, and is caused by 22q13.3 deletions or mutations in the SHAN...

    Authors: Michael S. Breen, Andrew Browne, Gabriel E. Hoffman, Sofia Stathopoulos, Kristen Brennand, Joseph D. Buxbaum and Elodie Drapeau

    Citation: Molecular Autism 2020 11:53

    Content type: Research

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  7. Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder. Notwithstanding the extensive studies using rodent and other pre...

    Authors: Shreya Das Sharma, Rakhi Pal, Bharath Kumar Reddy, Bhuvaneish T. Selvaraj, Nisha Raj, Krishna Kumar Samaga, Durga J. Srinivasan, Loren Ornelas, Dhruv Sareen, Matthew R. Livesey, Gary J. Bassell, Clive N. Svendsen, Peter C. Kind, Siddharthan Chandran, Sumantra Chattarji and David J. A. Wyllie

    Citation: Molecular Autism 2020 11:52

    Content type: Research

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  8. The frequently cited Early Overgrowth Hypothesis of autism spectrum disorder (ASD) postulates that there is overgrowth of the brain in the first 2 years of life, which is followed by a period of arrested growt...

    Authors: Lisa D. Yankowitz, John D. Herrington, Benjamin E. Yerys, Joseph A. Pereira, Juhi Pandey and Robert T. Schultz

    Citation: Molecular Autism 2020 11:51

    Content type: Research

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  9. Individuals with autism spectrum disorder (ASD) are characterized by social communication challenges and repetitive behaviors that may be quickly detected by experts (Autism Res 10:653–62, 2017; American Psych...

    Authors: Meredith L. Cola, Samantha Plate, Lisa Yankowitz, Victoria Petrulla, Leila Bateman, Casey J. Zampella, Ashley de Marchena, Juhi Pandey, Robert T. Schultz and Julia Parish-Morris

    Citation: Molecular Autism 2020 11:49

    Content type: Research

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  10. Autistic individuals exhibit atypical patterns of sensory processing that are known to be related to quality of life, but which are also highly heterogeneous. Previous investigations of this heterogeneity have...

    Authors: Patrick Dwyer, Xiaodong Wang, Rosanna De Meo-Monteil, Fushing Hsieh, Clifford D. Saron and Susan M. Rivera

    Citation: Molecular Autism 2020 11:48

    Content type: Research

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  11. In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead ...

    Authors: Lucia Janickova, Karin Farah Rechberger, Lucas Wey and Beat Schwaller

    Citation: Molecular Autism 2020 11:47

    Content type: Research

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  12. A crucial step to understanding the mechanistic underpinnings of autism spectrum disorder (ASD), is to examine if the biological underpinnings of ASD in genetic high-risk conditions, like 22q11.2 deletion synd...

    Authors: Maria Gudbrandsen, Anke Bletsch, Caroline Mann, Eileen Daly, Clodagh M. Murphy, Vladimira Stoencheva, Charlotte E. Blackmore, Maria Rogdaki, Leila Kushan, Carrie E. Bearden, Declan G. M. Murphy, Michael C. Craig and Christine Ecker

    Citation: Molecular Autism 2020 11:46

    Content type: Research

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  13. MBD5, encoding the methyl-CpG-binding domain 5 protein, has been proposed as a necessary and sufficient driver of the 2q23.1 microdeletion syndrome. De novo missense and protein-truncating variants from exome seq...

    Authors: Catarina M. Seabra, Tatsiana Aneichyk, Serkan Erdin, Derek J. C. Tai, Celine E. F. De Esch, Parisa Razaz, Yu An, Poornima Manavalan, Ashok Ragavendran, Alexei Stortchevoi, Clemer Abad, Juan I. Young, Patricia Maciel, Michael E. Talkowski and James F. Gusella

    Citation: Molecular Autism 2020 11:45

    Content type: Research

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  14. PTEN, a syndromic autism spectrum disorder (ASD) risk gene, is mutated in approximately 10% of macrocephalic ASD cases. Despite the described genetic association between PTEN and ASD and ensuing studies, we conti...

    Authors: Shin Chung Kang, Ritika Jaini, Masahiro Hitomi, Hyunpil Lee, Nick Sarn, Stetson Thacker and Charis Eng

    Citation: Molecular Autism 2020 11:43

    Content type: Research

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  15. Patients diagnosed with chromosome microdeletions or duplications, known as copy number variants (CNVs), present a unique opportunity to investigate the relationship between patient genotype and cell phenotype...

    Authors: Danijela Drakulic, Srdjan Djurovic, Yasir Ahmed Syed, Sebastiano Trattaro, Nicolò Caporale, Anna Falk, Rivka Ofir, Vivi M. Heine, Samuel J. R. A. Chawner, Antonio Rodriguez-Moreno, Marianne B. M. van den Bree, Giuseppe Testa, Spyros Petrakis and Adrian J. Harwood

    Citation: Molecular Autism 2020 11:42

    Content type: Review

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  16. FXS is the most common genetic cause of intellectual (ID) and autism spectrum disorders (ASD). FXS is caused by loss of FMRP, an RNA-binding protein involved in the translational regulation of a large number o...

    Authors: Kagistia Hana Utami, Nur Amirah Binte Mohammad Yusof, Jing Eugene Kwa, Ulla-Kaisa Peteri, Maija L. Castrén and Mahmoud A. Pouladi

    Citation: Molecular Autism 2020 11:41

    Content type: Research

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  17. Studies of individuals with autism spectrum disorder (ASD) have revealed a strong multigenic basis with the identification of hundreds of ASD susceptibility genes. ASD is characterized by social deficits and a...

    Authors: Maria Jesus Herrero, Dmitry Velmeshev, David Hernandez-Pineda, Saarthak Sethi, Shawn Sorrells, Payal Banerjee, Catherine Sullivan, Abha R. Gupta, Arnold R. Kriegstein and Joshua G. Corbin

    Citation: Molecular Autism 2020 11:39

    Content type: Research

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  18. Rett syndrome (RTT) is a progressive neurodevelopmental disease that is characterized by abnormalities in cognitive, social, and motor skills. RTT is often caused by mutations in the X-linked gene encoding met...

    Authors: Suzy Varderidou-Minasian, Lisa Hinz, Dominique Hagemans, Danielle Posthuma, Maarten Altelaar and Vivi M. Heine

    Citation: Molecular Autism 2020 11:38

    Content type: Research

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  19. Autism spectrum condition (ASC) is accompanied by developmental differences in brain anatomy and connectivity. White matter differences in ASC have been widely studied with diffusion imaging but results are he...

    Authors: Abigail Thompson, Asal Shahidiani, Anne Fritz, Jonathan O’Muircheartaigh, Lindsay Walker, Vera D’Almeida, Clodagh Murphy, Eileen Daly, Declan Murphy, Steve Williams, Sean Deoni and Christine Ecker

    Citation: Molecular Autism 2020 11:36

    Content type: Research

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  20. Whether there is a true increase in autism spectrum disorder (ASD) frequency or not remains unclear. Additionally, the rates of co-existing neurodevelopmental disorders (NDD) in a total population sample has n...

    Authors: Manabu Saito, Tomoya Hirota, Yui Sakamoto, Masaki Adachi, Michio Takahashi, Ayako Osato-Kaneda, Young Shin Kim, Bennett Leventhal, Amy Shui, Sumi Kato and Kazuhiko Nakamura

    Citation: Molecular Autism 2020 11:35

    Content type: Research

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  21. Youth with autism spectrum disorder (ASD) experience high rates (approximately 50–79%) of comorbid anxiety problems. Given the significant interference and distress that excessive anxiety can cause, evidence-b...

    Authors: Abbie Solish, Nora Klemencic, Anne Ritzema, Vicki Nolan, Martha Pilkington, Evdokia Anagnostou and Jessica Brian

    Citation: Molecular Autism 2020 11:34

    Content type: Research

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  22. Genetic factors contribute to the development of autism spectrum disorder (ASD), and although non-protein-coding regions of the genome are being increasingly implicated in ASD, the functional consequences of t...

    Authors: P. Joel Ross, Rebecca S. F. Mok, Brandon S. Smith, Deivid C. Rodrigues, Marat Mufteev, Stephen W. Scherer and James Ellis

    Citation: Molecular Autism 2020 11:33

    Content type: Review

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  23. Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent of this discrepancy is limited and inconsistent. Use of automate...

    Authors: Abigail Bangerter, Meenakshi Chatterjee, Joseph Manfredonia, Nikolay V. Manyakov, Seth Ness, Matthew A. Boice, Andrew Skalkin, Matthew S. Goodwin, Geraldine Dawson, Robert Hendren, Bennett Leventhal, Frederick Shic and Gahan Pandina

    Citation: Molecular Autism 2020 11:31

    Content type: Research

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  24. Tuberous sclerosis complex (TSC) is an autosomal dominant disease that affects multiple organs including the brain. TSC is strongly associated with broad neurodevelopmental disorders, including autism spectrum...

    Authors: Dorinde M. van Andel, Jan J. Sprengers, Bob Oranje, Floortje E. Scheepers, Floor E. Jansen and Hilgo Bruining

    Citation: Molecular Autism 2020 11:30

    Content type: Research

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  25. Mutations in TSC1 or TSC2 genes cause tuberous sclerosis complex (TSC), a disorder associated with epilepsy, autism, and intellectual disability. TSC1 and TSC2 are repressors of the mechanistic target of rapamyci...

    Authors: Nabila Haji, Ilse Riebe, Argel Aguilar-Valles, Julien Artinian, Isabel Laplante and Jean-Claude Lacaille

    Citation: Molecular Autism 2020 11:29

    Content type: Research

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  26. Although there is high co-occurrence between ASD and ADHD, the nature of this co-occurrence remains unclear. Our study aimed to examine the underlying relationship between ASD and ADHD symptoms in a combined s...

    Authors: Aneta D. Krakowski, Katherine Tombeau Cost, Evdokia Anagnostou, Meng-Chuan Lai, Jennifer Crosbie, Russell Schachar, Stelios Georgiades, Eric Duku and Peter Szatmari

    Citation: Molecular Autism 2020 11:28

    Content type: Research

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  27. Proteomics is the large-scale study of the total protein content and their overall function within a cell through multiple facets of research. Advancements in proteomic methods have moved past the simple quant...

    Authors: Nadeem Murtaza, Jarryll Uy and Karun K. Singh

    Citation: Molecular Autism 2020 11:27

    Content type: Review

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  28. Elucidating developmental changes in the symptoms of autism spectrum disorder (ASD) is important to support individuals with ASD. However, no report has clarified the developmental changes in attention to soci...

    Authors: Toru Fujioka, Kenji J. Tsuchiya, Manabu Saito, Yoshiyuki Hirano, Muneaki Matsuo, Mitsuru Kikuchi, Yoshihiro Maegaki, Damee Choi, Sumi Kato, Tokiko Yoshida, Yuko Yoshimura, Sawako Ooba, Yoshifumi Mizuno, Shinichiro Takiguchi, Hideo Matsuzaki, Akemi Tomoda…

    Citation: Molecular Autism 2020 11:24

    Content type: Research

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  29. Efforts to identify the causes of autism spectrum disorders have highlighted the importance of both genetics and environment, but the lack of human models for many of these disorders limits researchers’ attemp...

    Authors: Karina A. Kruth, Tierney M. Grisolano, Christopher A. Ahern and Aislinn J. Williams

    Citation: Molecular Autism 2020 11:23

    Content type: Review

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  30. Formation and maintenance of appropriate neural networks require tight regulation of neural stem cell proliferation, differentiation, and neurogenesis. microRNAs (miRNAs) play an important role in brain develo...

    Authors: Julien Fregeac, Stéphanie Moriceau, Antoine Poli, Lam Son Nguyen, Franck Oury and Laurence Colleaux

    Citation: Molecular Autism 2020 11:22

    Content type: Research

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  31. Oxytocin administration, which may be of therapeutic value for individuals with social difficulties, is likely to affect endogenous levels of other socially relevant hormones. However, to date, the effects of ...

    Authors: Tanya L. Procyshyn, Michael V. Lombardo, Meng-Chuan Lai, Bonnie Auyeung, Sarah K. Crockford, J Deakin, S. Soubramanian, A Sule, Simon Baron-Cohen and Richard A. I. Bethlehem

    Citation: Molecular Autism 2020 11:20

    Content type: Research

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  32. DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-110, is an excitatory postsynaptic scaffolding protein that interacts with synaptic surface receptors and signaling molecules. A recent s...

    Authors: Taesun Yoo, Sun-Gyun Kim, Soo Hyun Yang, Hyun Kim, Eunjoon Kim and Soo Young Kim

    Citation: Molecular Autism 2020 11:19

    Content type: Research

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  33. Previous research using the Sensory Perception Quotient (SPQ) has reported greater sensory hypersensitivity in people with autism spectrum condition (ASC) compared to controls, consistent with other research. ...

    Authors: Emily Taylor, Rosemary Holt, Teresa Tavassoli, Chris Ashwin and Simon Baron-Cohen

    Citation: Molecular Autism 2020 11:18

    Content type: Research

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  34. Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterat...

    Authors: Carolin Moessnang, Sarah Baumeister, Julian Tillmann, David Goyard, Tony Charman, Sara Ambrosino, Simon Baron-Cohen, Christian Beckmann, Sven Bölte, Carsten Bours, Daisy Crawley, Flavio Dell’Acqua, Sarah Durston, Christine Ecker, Vincent Frouin, Hannah Hayward…

    Citation: Molecular Autism 2020 11:17

    Content type: Research

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  35. Autistic individuals without intellectual disability are at heightened risk of self-injury, and appear to engage in it for similar reasons as non-autistic people. A wide divergence of autistic perspectives on ...

    Authors: R. L. Moseley, N. J. Gregory, P. Smith, C. Allison and S. Baron-Cohen

    Citation: Molecular Autism 2020 11:14

    Content type: Research

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