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  1. Anxiety is prevalent in autism spectrum disorder (ASD) and can negatively impact physical and mental health. Self-awareness of anxiety signs is a key barrier to success of anxiety interventions for many children.

    Authors: Jenny Nguyen, Robyn E. Cardy, Evdokia Anagnostou, Jessica Brian and Azadeh Kushki

    Citation: Molecular Autism 2021 12:72

    Content type: Research

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  2. Inhibitory control and attention processing atypicalities are implicated in various diseases, including autism spectrum disorders (ASD). These cognitive functions can be tested by using visually guided saccade...

    Authors: Anouck Amestoy, Etienne Guillaud, Giulia Bucchioni, Tiziana Zalla, Daniel Umbricht, Christopher Chatham, Lorraine Murtagh, Josselin Houenou, Richard Delorme, Miriam Ly-Le Moal, Marion Leboyer, Manuel Bouvard and Jean-René Cazalets

    Citation: Molecular Autism 2021 12:71

    Content type: Research

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  3. De novo variants in the voltage-gated calcium channel subunit α1 E gene (CACNA1E) have been described as causative of epileptic encephalopathy with contractures, macrocephaly and dyskinesias.

    Authors: Beryl Royer-Bertrand, Marine Jequier Gygax, Katarina Cisarova, Jill A. Rosenfeld, Jennifer A. Bassetti, Oana Moldovan, Emily O’Heir, Lindsay C. Burrage, Jake Allen, Lisa T. Emrick, Emma Eastman, Camille Kumps, Safdar Abbas, Geraldine Van Winckel, Nadia Chabane, Elaine H. Zackai…

    Citation: Molecular Autism 2021 12:69

    Content type: Research

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  4. Immune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described ...

    Authors: Pierre Ellul, Michelle Rosenzwajg, Hugo Peyre, Gwladys Fourcade, Encarnita Mariotti-Ferrandiz, Vincent Trebossen, David Klatzmann and Richard Delorme

    Citation: Molecular Autism 2021 12:68

    Content type: Research

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  5. Atypical reactions to the sensory environment are often reported in autistic individuals, with a high degree of variability across the sensory modalities. These sensory differences have been shown to promote c...

    Authors: Nichole E. Scheerer, Kristina Curcin, Bobby Stojanoski, Evdokia Anagnostou, Rob Nicolson, Elizabeth Kelley, Stelios Georgiades, Xudong Liu and Ryan A. Stevenson

    Citation: Molecular Autism 2021 12:67

    Content type: Research

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  6. Genetic studies have implicated rare and common variations in liability for autism spectrum disorder (ASD). Of the discovered risk variants, those rare in the population invariably have large impact on liabili...

    Authors: Lambertus Klei, Lora Lee McClain, Behrang Mahjani, Klea Panayidou, Silvia De Rubeis, Anna-Carin Säll Grahnat, Gun Karlsson, Yangyi Lu, Nadine Melhem, Xinyi Xu, Abraham Reichenberg, Sven Sandin, Christina M. Hultman, Joseph D. Buxbaum, Kathryn Roeder and Bernie Devlin

    Citation: Molecular Autism 2021 12:66

    Content type: Research

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  7. The Autism Sequencing Consortium identified 102 high-confidence autism spectrum disorder (ASD) genes, showing that individuals with ASD and with potentially damaging single nucleotide variation (pdSNV) in thes...

    Authors: Behrang Mahjani, Silvia De Rubeis, Christina Gustavsson Mahjani, Maureen Mulhern, Xinyi Xu, Lambertus Klei, F. Kyle Satterstrom, Jack Fu, Michael E. Talkowski, Abraham Reichenberg, Sven Sandin, Christina M. Hultman, Dorothy E. Grice, Kathryn Roeder, Bernie Devlin and Joseph D. Buxbaum

    Citation: Molecular Autism 2021 12:65

    Content type: Research

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  8. According to Bayesian hypotheses, individuals with Autism Spectrum Disorder (ASD) have difficulties making accurate predictions about their environment. In particular, the mechanisms by which they assign preci...

    Authors: Laurie-Anne Sapey-Triomphe, Joke Temmerman, Nicolaas A. J. Puts and Johan Wagemans

    Citation: Molecular Autism 2021 12:64

    Content type: Research

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  9. The majority of research examining emotional difficulties in autism spectrum disorder (ASD) prior to age 2 relies on parent report.

    Authors: Lori-Ann R. Sacrey, Lonnie Zwaigenbaum, Jessica A. Brian, Isabel M. Smith, Vickie Armstrong, Sarah Raza, Tracy Vaillancourt and Louis A. Schmidt

    Citation: Molecular Autism 2021 12:63

    Content type: Research

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  10. Phelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder caused by haploinsufficiency of the SHANK3 gene and characterized by global developmental delays, deficits in speech and motor function, and au...

    Authors: J. Fastman, J. Foss-Feig, Y. Frank, D. Halpern, H. Harony-Nicolas, C. Layton, S. Sandin, P. Siper, L. Tang, P. Trelles, J. Zweifach, J. D. Buxbaum and A. Kolevzon

    Citation: Molecular Autism 2021 12:62

    Content type: Research

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  11. FOXP1 syndrome is an autosomal dominant neurodevelopmental disorder characterized by intellectual disability, developmental delay, speech and language delays, and externalizing behaviors. We previously evaluat...

    Authors: M. Pilar Trelles, Tess Levy, Bonnie Lerman, Paige Siper, Reymundo Lozano, Danielle Halpern, Hannah Walker, Jessica Zweifach, Yitzchak Frank, Jennifer Foss-Feig, Alexander Kolevzon and Joseph Buxbaum

    Citation: Molecular Autism 2021 12:61

    Content type: Research

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  12. Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, in...

    Authors: Stephanie Antoun, Pierre Ellul, Hugo Peyre, Michelle Rosenzwajg, Pierre Gressens, David Klatzmann and Richard Delorme

    Citation: Molecular Autism 2021 12:60

    Content type: Research

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  13. Angelman Syndrome (AS) is a rare neurodevelopmental disorder for which there is currently no cure or effective therapeutic. Since the genetic cause of AS is known to be dysfunctional expression of the maternal...

    Authors: Elizabeth L. Berg, Stela P. Petkova, Heather A. Born, Anna Adhikari, Anne E. Anderson and Jill L. Silverman

    Citation: Molecular Autism 2021 12:59

    Content type: Research

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  14. Restricted and repetitive behavior (RRB) is one of the characteristic features of Autism Spectrum Disorder. This domain of symptoms includes a broad range of behaviors. There is a need to study each behavior i...

    Authors: V. Courchesne, R. Bedford, A. Pickles, E. Duku, C. Kerns, P. Mirenda, T. Bennett, S. Georgiades, I. M. Smith, W. J. Ungar, T. Vaillancourt, A. Zaidman-Zait, L. Zwaigenbaum, P. Szatmari and M. Elsabbagh

    Citation: Molecular Autism 2021 12:57

    Content type: Research

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  15. Alexithymia, a personality trait characterized by difficulties interpreting emotional states, is commonly elevated in autistic adults, and a growing body of literature suggests that this trait underlies severa...

    Authors: Zachary J. Williams and Katherine O. Gotham

    Citation: Molecular Autism 2021 12:56

    Content type: Research

    Published on:

  16. ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD ...

    Authors: Rachael Knott, Beth P. Johnson, Jeggan Tiego, Olivia Mellahn, Amy Finlay, Kathryn Kallady, Maria Kouspos, Vishnu Priya Mohanakumar Sindhu, Ziarih Hawi, Aurina Arnatkeviciute, Tracey Chau, Dalia Maron, Emily-Clare Mercieca, Kirsten Furley, Katrina Harris, Katrina Williams…

    Citation: Molecular Autism 2021 12:55

    Content type: Methodology

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  17. Sleep disturbances in autism spectrum disorder (ASD) represent a common and vexing comorbidity. Clinical heterogeneity amongst these warrants studies of the mechanisms associated with specific genetic etiologi...

    Authors: Vidya Saravanapandian, Divya Nadkarni, Sheng-Hsiou Hsu, Shaun A. Hussain, Kiran Maski, Peyman Golshani, Christopher S. Colwell, Saravanavel Balasubramanian, Amos Dixon, Daniel H. Geschwind and Shafali S. Jeste

    Citation: Molecular Autism 2021 12:54

    Content type: Research

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  18. RASopathies are a group of disorders that result from mutations in genes coding for proteins involved in regulating the Ras-MAPK signaling pathway, and have an increased incidence of autism spectrum disorder (...

    Authors: Sarah C. Borrie, Ellen Plasschaert, Zsuzsanna Callaerts-Vegh, Akihiko Yoshimura, Rudi D’Hooge, Ype Elgersma, Steven A. Kushner, Eric Legius and Hilde Brems

    Citation: Molecular Autism 2021 12:53

    Content type: Research

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  19. Sensorimotor issues are common in autism spectrum disorder (ASD), related to core symptoms, and predictive of worse functional outcomes. Deficits in rapid behaviors supported primarily by feedforward mechanism...

    Authors: Kathryn E. Unruh, Walker S. McKinney, Erin K. Bojanek, Kandace K. Fleming, John A. Sweeney and Matthew W. Mosconi

    Citation: Molecular Autism 2021 12:52

    Content type: Research

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  20. Prenatal sex steroids have been associated with autism in several clinical and epidemiological studies. It is unclear how this relates to the autistic traits of the mother and how early this can be detected du...

    Authors: A. Tsompanidis, E. Aydin, E. Padaigaitė, G. Richards, C. Allison, G. Hackett, T. Austin, R. Holt and S. Baron-Cohen

    Citation: Molecular Autism 2021 12:51

    Content type: Research

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  21. Rhesus monkeys (Macaca mulatta) exhibit pronounced individual differences in social traits as measured by the macaque Social Responsiveness Scale-Revised. The macaque Social Responsiveness Scale was previously ad...

    Authors: Ozge Oztan, Catherine F. Talbot, Emanuela Argilli, Alyssa C. Maness, Sierra M. Simmons, Noreen Mohsin, Laura A. Del Rosso, Joseph P. Garner, Elliott H. Sherr, John P. Capitanio and Karen J. Parker

    Citation: Molecular Autism 2021 12:50

    Content type: Research

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  22. Autism spectrum disorder (ASD) has a high cost to affected individuals and society, but treatments for core symptoms are lacking. To expand intervention options, it is crucial to gain a better understanding of...

    Authors: Charlotte M. Pretzsch, Dorothea L. Floris, Bogdan Voinescu, Malka Elsahib, Maria A. Mendez, Robert Wichers, Laura Ajram, Glynis Ivin, Martin Heasman, Elise Pretzsch, Steven Williams, Declan G. M. Murphy, Eileen Daly and Gráinne M. McAlonan

    Citation: Molecular Autism 2021 12:49

    Content type: Research

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  23. Evidences suggesting the association between behavioral anomalies in autism and white matter (WM) microstructural alterations are increasing. Diffusion tensor imaging (DTI) is widely used to infer tissue micro...

    Authors: Christina Andica, Koji Kamagata, Eiji Kirino, Wataru Uchida, Ryusuke Irie, Syo Murata and Shigeki Aoki

    Citation: Molecular Autism 2021 12:48

    Content type: Research

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  24. Recent research suggests a link between autism spectrum disorder (ASD) and anorexia nervosa (AN). Individuals with AN show high scores on measures of ASD symptoms, relative to individuals without AN, however, ...

    Authors: Jess Kerr-Gaffney, Hannah Hayward, Emily J. H. Jones, Daniel Halls, Declan Murphy and Kate Tchanturia

    Citation: Molecular Autism 2021 12:47

    Content type: Research

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  25. Autistic people and those with high autistic traits are at high risk of experiencing suicidality. Yet, there are no suicidality assessment tools developed or validated for these groups.

    Authors: Sarah A. Cassidy, Louise Bradley, Heather Cogger-Ward and Jacqui Rodgers

    Citation: Molecular Autism 2021 12:46

    Content type: Research

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  26. Authors: Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li‑Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye and Jed W. Fahey

    Citation: Molecular Autism 2021 12:44

    Content type: Correction

    Published on:

    The original article was published in Molecular Autism 2021 12:38

  27. Neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) display a strong male bias. Androgen exposure is profoundly increased in typical male development, but it also varies within the sexes...

    Authors: Brooke G. McKenna, Yongchao Huang, Kévin Vervier, Dabney Hofammann, Mary Cafferata, Seima Al-Momani, Florencia Lowenthal, Angela Zhang, Jin-Young Koh, Savantha Thenuwara, Leo Brueggeman, Ethan Bahl, Tanner Koomar, Natalie Pottschmidt, Taylor Kalmus, Lucas Casten…

    Citation: Molecular Autism 2021 12:43

    Content type: Research

    Published on:

  28. Individuals on the autism spectrum are reported to display alterations in interoception, the sense of the internal state of the body. The Interoception Sensory Questionnaire (ISQ) is a 20-item self-report meas...

    Authors: Evan Suzman, Zachary J. Williams, Jacob I. Feldman, Michelle Failla, Carissa J. Cascio, Mark T. Wallace, Maria Niarchou, James S. Sutcliffe, Ericka Wodka and Tiffany G. Woynaroski

    Citation: Molecular Autism 2021 12:42

    Content type: Research

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  29. Autism spectrum disorder (ASD) has a strong genetic etiology. Germline mutation in the tumor suppressor gene PTEN is one of the best described monogenic risk cases for ASD. Animal modeling of cell-specific Pten l...

    Authors: Nick Sarn, Stetson Thacker, Hyunpil Lee and Charis Eng

    Citation: Molecular Autism 2021 12:41

    Content type: Research

    Published on:

  30. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13229-021-00446-6

    Authors: Zachary J. Williams and Katherine O. Gotham

    Citation: Molecular Autism 2021 12:40

    Content type: Retraction Note

    Published on:

    The original article was published in Molecular Autism 2021 12:20

  31. Restricted and repetitive behaviors (RRB) in autism spectrum disorder (ASD) encompass several distinct domains. However, commonly used general ASD measures provide broad RRB scores rather than assessing separa...

    Authors: Mirko Uljarević, Booil Jo, Thomas W. Frazier, Lawrence Scahill, Eric A. Youngstrom and Antonio Y. Hardan

    Citation: Molecular Autism 2021 12:39

    Content type: Research

    Published on:

  32. Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials o...

    Authors: Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye and Jed W. Fahey

    Citation: Molecular Autism 2021 12:38

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Autism 2021 12:44

  33. Traits and characteristics qualitatively similar to those seen in diagnosed autism spectrum disorder can be found to varying degrees in the general population. To measure these traits and facilitate their use ...

    Authors: Michael C. W. English, Gilles E. Gignac, Troy A. W. Visser, Andrew J. O. Whitehouse, James T. Enns and Murray T. Maybery

    Citation: Molecular Autism 2021 12:37

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Autism 2021 12:70

  34. DDX3X syndrome is a recently identified genetic disorder that accounts for 1–3% of cases of unexplained developmental delay and/or intellectual disability (ID) in females, and is associated with motor and lang...

    Authors: Lara Tang, Tess Levy, Sylvia Guillory, Danielle Halpern, Jessica Zweifach, Ivy Giserman-Kiss, Jennifer H. Foss-Feig, Yitzchak Frank, Reymundo Lozano, Puneet Belani, Christina Layton, Bonnie Lerman, Emanuel Frowner, Michael S. Breen, Silvia De Rubeis, Ana Kostic…

    Citation: Molecular Autism 2021 12:36

    Content type: Research

    Published on:

  35. Language delay is one of the major referral criteria for an autism evaluation. Once an autism spectrum diagnosis is established, the language prognosis is among the main parental concerns. Early language regre...

    Authors: David Gagnon, Abderrahim Zeribi, Élise Douard, Valérie Courchesne, Borja Rodríguez-Herreros, Guillaume Huguet, Sébastien Jacquemont, Mor Absa Loum and Laurent Mottron

    Citation: Molecular Autism 2021 12:35

    Content type: Research

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  36. Autism has previously been characterized by both structural and functional differences in brain connectivity. However, while the literature on single-subject derivations of functional connectivity is extensive...

    Authors: Matthew J. Leming, Simon Baron-Cohen and John Suckling

    Citation: Molecular Autism 2021 12:34

    Content type: Research

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  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jessica A. Jiménez, Travis S. Ptacek, Alex H. Tuttle, Ralf S. Schmid, Sheryl S. Moy, Jeremy M. Simon and Mark J. Zylka

    Citation: Molecular Autism 2021 12:33

    Content type: Correction

    Published on:

    The original article was published in Molecular Autism 2020 11:74

  38. Intervention during the first years of life for children with autism spectrum disorder (ASD) may have the strongest impact on long-term brain development and functioning. Yet, barriers such as a shortage of tr...

    Authors: Allison L. Wainer, Zachary E. Arnold, Caroline Leonczyk and Latha Valluripalli Soorya

    Citation: Molecular Autism 2021 12:32

    Content type: Research

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  39. Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neur...

    Authors: Michael. G. Mariscal, Elizabeth Berry-Kravis, Joseph D. Buxbaum, Lauren E. Ethridge, Rajna Filip-Dhima, Jennifer H. Foss-Feig, Alexander Kolevzon, Meera. E. Modi, Matthew W. Mosconi, Charles A. Nelson, Craig M. Powell, Paige M. Siper, Latha Soorya, Andrew Thaliath, Audrey Thurm, Bo Zhang…

    Citation: Molecular Autism 2021 12:29

    Content type: Research

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  40. Unusual behavioral reactions to sensory stimuli are frequently reported in individuals on the autism spectrum (AS). Despite the early emergence of sensory features (< age 3) and their potential impact on devel...

    Authors: Svenja Espenhahn, Kate J. Godfrey, Sakshi Kaur, Maia Ross, Niloy Nath, Olesya Dmitrieva, Carly McMorris, Filomeno Cortese, Charlene Wright, Kara Murias, Deborah Dewey, Andrea B. Protzner, Adam McCrimmon, Signe Bray and Ashley D. Harris

    Citation: Molecular Autism 2021 12:26

    Content type: Research

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  41. One of the causal mechanisms underlying neurodevelopmental disorders (NDDs) is chromatin modification and the genes that regulate chromatin. AT-rich interactive domain 1B (ARID1B), a chromatin modifier, has been ...

    Authors: J. Ellegood, S. P. Petkova, A. Kinman, L. R. Qiu, A. Adhikari, A. A. Wade, D. Fernandes, Z. Lindenmaier, A. Creighton, L. M. J. Nutter, A. S. Nord, J. L. Silverman and J. P. Lerch

    Citation: Molecular Autism 2021 12:25

    Content type: Research

    Published on:

  42. The Early Markers for Autism (EMA) study is a population-based case–control study designed to learn more about early biologic processes involved in ASD.

    Authors: Kristen Lyall, Jennifer L. Ames, Michelle Pearl, Michela Traglia, Lauren A. Weiss, Gayle C. Windham, Martin Kharrazi, Cathleen K. Yoshida, Robert Yolken, Heather E. Volk, Paul Ashwood, Judy Van de Water and Lisa A. Croen

    Citation: Molecular Autism 2021 12:24

    Content type: Review

    Published on:

  43. Autism spectrum disorders (ASD) are synaptopathies characterized by area-specific synaptic alterations and neuroinflammation. Structural and adhesive features of hippocampal synapses have been described in the...

    Authors: Marianela Evelyn Traetta, Martín Gabriel Codagnone, Nonthué Alejandra Uccelli, Alberto Javier Ramos, Sandra Zárate and Analía Reinés

    Citation: Molecular Autism 2021 12:23

    Content type: Research

    Published on:

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