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  1. Content type: Research

    Loss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be lea...

    Authors: Alain C. Burette, Matthew C. Judson, Alissa N. Li, Edward F. Chang, William W. Seeley, Benjamin D. Philpot and Richard J. Weinberg

    Citation: Molecular Autism 2018 9:54

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  2. Content type: Research

    Savant syndrome is a condition where prodigious talent can co-occur with developmental conditions such as autism spectrum conditions (autism). It is not yet clear why some autistic people develop savant skills...

    Authors: James E A Hughes, Jamie Ward, Elin Gruffydd, Simon Baron-Cohen, Paula Smith, Carrie Allison and Julia Simner

    Citation: Molecular Autism 2018 9:53

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  3. Content type: Research

    Rapid automatized naming (RAN; naming of familiar items presented in an array) is a task that taps fundamental neurocognitive processes that are affected in a number of complex psychiatric conditions. Deficits...

    Authors: Kritika Nayar, Peter C Gordon, Gary E Martin, Abigail L Hogan, Chelsea La Valle, Walker McKinney, Michelle Lee, Elizabeth S Norton and Molly Losh

    Citation: Molecular Autism 2018 9:51

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  4. Content type: Research

    Many young people with autism spectrum disorder (ASD) experience emotional and behavioural problems. However, the causes of these co-occurring difficulties are not well understood. Perceptual processing atypic...

    Authors: Virginia Carter Leno, Susie Chandler, Pippa White, Isabel Yorke, Tony Charman, Andrew Pickles and Emily Simonoff

    Citation: Molecular Autism 2018 9:50

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  5. Content type: Research

    Histological evidence suggests that autism spectrum disorder (ASD) is accompanied by a reduced integrity of the grey-white matter boundary. This has also recently been confirmed by a structural neuroimaging st...

    Authors: Caroline Mann, Anke Bletsch, Derek Andrews, Eileen Daly, Clodagh Murphy, Declan Murphy and Christine Ecker

    Citation: Molecular Autism 2018 9:49

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  6. Content type: Research

    Autism spectrum disorders (ASDs) are a heterogeneous group of behaviorally defined disorders and are associated with hundreds of rare genetic mutations and several environmental risk factors. Mouse models of s...

    Authors: Emily A. Brown, Jonathan D. Lautz, Tessa R. Davis, Edward P. Gniffke, Alison A. W. VanSchoiack, Steven C. Neier, Noah Tashbook, Chiara Nicolini, Margaret Fahnestock, Adam G. Schrum and Stephen E. P. Smith

    Citation: Molecular Autism 2018 9:48

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  7. Content type: Research

    Angelman syndrome (AS) is a neurodevelopmental disorder caused by mutations affecting UBE3A function. AS is characterized by intellectual disability, impaired motor coordination, epilepsy, and behavioral abnor...

    Authors: Monica Sonzogni, Ilse Wallaard, Sara Silva Santos, Jenina Kingma, Dorine du Mee, Geeske M. van Woerden and Ype Elgersma

    Citation: Molecular Autism 2018 9:47

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  8. Content type: Research

    A growing body of anecdotal evidence indicates that the use of robots may provide unique opportunities for assisting children with autism spectrum disorders (ASD). However, previous studies investigating the e...

    Authors: Hirokazu Kumazaki, Yuichiro Yoshikawa, Yuko Yoshimura, Takashi Ikeda, Chiaki Hasegawa, Daisuke N. Saito, Sara Tomiyama, Kyung-min An, Jiro Shimaya, Hiroshi Ishiguro, Yoshio Matsumoto, Yoshio Minabe and Mitsuru Kikuchi

    Citation: Molecular Autism 2018 9:46

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  9. Content type: Research

    Angelman syndrome (AS) is a severe neurodevelopmental disorder lacking effective therapies. AS is caused by mutations in ubiquitin protein ligase E3A (UBE3A), which is genomically imprinted such that only the mat...

    Authors: Hyeong-Min Lee, Ellen P. Clark, M. Bram Kuijer, Mark Cushman, Yves Pommier and Benjamin D. Philpot

    Citation: Molecular Autism 2018 9:45

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  10. Content type: Research

    Lowe syndrome (LS) is a rare genetic disorder caused by loss of function mutations in the X-linked gene, OCRL, which codes for inositol polyphosphate 5-phosphatase. LS is characterized by the triad of congenital ...

    Authors: Jesse Barnes, Franklin Salas, Ryan Mokhtari, Hedwig Dolstra, Erika Pedrosa and Herbert M. Lachman

    Citation: Molecular Autism 2018 9:44

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  11. Content type: Research

    Recent literatures indicate that maternal hormone exposure is a risk factor for autism spectrum disorder (ASD). We hypothesize that prenatal progestin exposure may counteract the neuroprotective effect of estr...

    Authors: Weiguo Xie, Xiaohu Ge, Ling Li, Athena Yao, Xiaoyan Wang, Min Li, Xiang Gong, Zhigang Chu, Zhe Lu, Xiaodong Huang, Yun Jiao, Yifei Wang, Meifang Xiao, Haijia Chen, Wei Xiang and Paul Yao

    Citation: Molecular Autism 2018 9:43

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  12. Content type: Research

    Research has shown high rates of suicidality in autism spectrum conditions (ASC), but there is lack of research into why this is the case. Many common experiences of autistic adults, such as depression or unemplo...

    Authors: Sarah Cassidy, Louise Bradley, Rebecca Shaw and Simon Baron-Cohen

    Citation: Molecular Autism 2018 9:42

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  13. Content type: Research

    Inherited abnormalities of perception, recognition, and attention to faces have been implicated in the etiology of autism spectrum disorders (ASD) including abnormal components of event-related brain potential...

    Authors: Olga V. Sysoeva, John N. Constantino and Andrey P. Anokhin

    Citation: Molecular Autism 2018 9:41

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  14. Content type: Short report

    Several reports have suggested a role for epigenetic mechanisms in ASD etiology. Epigenome-wide association studies (EWAS) in autism spectrum disorder (ASD) may shed light on particular biological mechanisms. ...

    Authors: Shan V. Andrews, Brooke Sheppard, Gayle C. Windham, Laura A. Schieve, Diana E. Schendel, Lisa A. Croen, Pankaj Chopra, Reid S. Alisch, Craig J. Newschaffer, Stephen T. Warren, Andrew P. Feinberg, M. Daniele Fallin and Christine Ladd-Acosta

    Citation: Molecular Autism 2018 9:40

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  15. Content type: Research

    MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs have emerged as important modulators of brain development and neuronal function and are imp...

    Authors: Lam Son Nguyen, Julien Fregeac, Christine Bole-Feysot, Nicolas Cagnard, Anand Iyer, Jasper Anink, Eleonora Aronica, Olivier Alibeu, Patrick Nitschke and Laurence Colleaux

    Citation: Molecular Autism 2018 9:38

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  16. Content type: Research

    Nausea and vomiting during pregnancy (NVP) is thought to be caused by changes in maternal hormones during pregnancy. Differences in hormone exposure during prenatal life have been implicated in the causal path...

    Authors: Andrew J. O. Whitehouse, Gail A. Alvares, Dominique Cleary, Alexis Harun, Angela Stojanoska, Lauren J. Taylor, Kandice J. Varcin and Murray Maybery

    Citation: Molecular Autism 2018 9:37

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  17. Content type: Research

    Autism spectrum disorder (ASD) is characterized by impaired social interactions and repetitive patterns of behavior. Symptoms appear in early life and persist throughout adulthood. Early social stimulation can...

    Authors: Marcos Campolongo, Nadia Kazlauskas, German Falasco, Leandro Urrutia, Natalí Salgueiro, Christian Höcht and Amaicha Mara Depino

    Citation: Molecular Autism 2018 9:36

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  18. Content type: Research

    Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterat...

    Authors: Stephen Bent, Brittany Lawton, Tracy Warren, Felicia Widjaja, Katherine Dang, Jed W. Fahey, Brian Cornblatt, Jason M. Kinchen, Kevin Delucchi and Robert L. Hendren

    Citation: Molecular Autism 2018 9:35

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  19. Content type: Research

    Past studies have shown that robot-based intervention was effective in improving gestural use in children with autism spectrum disorders (ASD). The present study examined whether children with ASD could catch ...

    Authors: Wing-Chee So, Miranda Kit-Yi Wong, Wan-Yi Lam, Chun-Ho Cheng, Jia-Hao Yang, Ying Huang, Phoebe Ng, Wai-Leung Wong, Chiu-Lok Ho, Kit-Ling Yeung and Cheuk-Chi Lee

    Citation: Molecular Autism 2018 9:34

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  20. Content type: Research

    Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by psychiatric and neurological features. Most reported cases are caused by 22q13.3 deletions, leading to SHANK3 haploinsufficiency, b...

    Authors: Silvia De Rubeis, Paige M. Siper, Allison Durkin, Jordana Weissman, François Muratet, Danielle Halpern, Maria del Pilar Trelles, Yitzchak Frank, Reymundo Lozano, A. Ting Wang, J. Lloyd Holder Jr, Catalina Betancur, Joseph D. Buxbaum and Alexander Kolevzon

    Citation: Molecular Autism 2018 9:31

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  21. Content type: Research

    Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. Individuals with AS...

    Authors: Hanna den Bakker, Michael S. Sidorov, Zheng Fan, David J. Lee, Lynne M. Bird, Catherine J. Chu and Benjamin D. Philpot

    Citation: Molecular Autism 2018 9:32

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  22. Content type: Research

    Mercury (Hg) has been suspected of causing autism in the past, especially a suspected link with vaccinations containing thiomersal, but a review of the literature shows that has been largely repudiated. Of mor...

    Authors: Jean Golding, Dheeraj Rai, Steven Gregory, Genette Ellis, Alan Emond, Yasmin Iles-Caven, Joseph Hibbeln and Caroline Taylor

    Citation: Molecular Autism 2018 9:30

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  23. Content type: Research

    Alu elements are a group of repetitive elements that can influence gene expression through CpG residues and transcription factor binding. Altered gene expression and methylation profiles have been reported in ...

    Authors: Thanit Saeliw, Chayanin Tangsuwansri, Surangrat Thongkorn, Weerasak Chonchaiya, Kanya Suphapeetiporn, Apiwat Mutirangura, Tewin Tencomnao, Valerie W. Hu and Tewarit Sarachana

    Citation: Molecular Autism 2018 9:27

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  24. Content type: Letter to the Editor

    EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Pr...

    Authors: Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K. Buitelaar, Eva Loth, Declan G. M. Murphy, Will Spooren and Sven Bölte

    Citation: Molecular Autism 2018 9:26

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  25. Content type: Research

    The serotonin (5-HT) system has long been implicated in autism spectrum disorder (ASD) as indicated by elevated whole blood and platelet 5-HT, altered platelet and brain receptor and transporter binding, and g...

    Authors: Jacob Ellegood, Yohan Yee, Travis M. Kerr, Christopher L. Muller, Randy D. Blakely, R. Mark Henkelman, Jeremy Veenstra-VanderWeele and Jason P. Lerch

    Citation: Molecular Autism 2018 9:24

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  26. Content type: Research

    Human genetic and genomic studies have supported a strong causal role of SHANK3 deficiency in autism spectrum disorder (ASD). However, the molecular mechanism underlying SHANK3 deficiency resulting in ASD is not ...

    Authors: Chun-xue Liu, Chun-yang Li, Chun-chun Hu, Yi Wang, Jia Lin, Yong-hui Jiang, Qiang Li and Xiu Xu

    Citation: Molecular Autism 2018 9:23

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  27. Content type: Research

    Sensory abnormalities and sleep disturbances are highly prevalent in children with autism, but the potential relationship between these two domains has rarely been explored. Understanding such relationships is...

    Authors: Orna Tzischinsky, Gal Meiri, Liora Manelis, Asif Bar-Sinai, Hagit Flusser, Analya Michaelovski, Orit Zivan, Michal Ilan, Michal Faroy, Idan Menashe and Ilan Dinstein

    Citation: Molecular Autism 2018 9:22

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  28. Content type: Short report

    Studies have investigated the risk of autism spectrum disorder (ASD) in children exposed in utero to antidepressant, with inconsistent results. Given the substantial public health implications on this topic, h...

    Authors: Xi-Hong Zhou, Yong-Jiang Li, Jian-Jun Ou and Ya-Min Li

    Citation: Molecular Autism 2018 9:21

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  29. Content type: Research

    Haploinsufficiency of the class I bHLH transcription factor TCF4 causes Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants in the TCF4 gene have been identified as susceptib...

    Authors: Matthias Jung, Benjamin M. Häberle, Tristan Tschaikowsky, Marie-Theres Wittmann, Elli-Anna Balta, Vivien-Charlott Stadler, Christiane Zweier, Arnd Dörfler, Christian Johannes Gloeckner and D. Chichung Lie

    Citation: Molecular Autism 2018 9:20

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  30. Content type: Research

    The wide range of ability and disability in ASD creates a need for tools that parse the phenotypic heterogeneity into meaningful subtypes. Using eye tracking, our past studies revealed that when presented with...

    Authors: Adrienne Moore, Madeline Wozniak, Andrew Yousef, Cindy Carter Barnes, Debra Cha, Eric Courchesne and Karen Pierce

    Citation: Molecular Autism 2018 9:19

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  31. Content type: Short report

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD ...

    Authors: Debra S. Karhson, Karolina M. Krasinska, Jamie Ahloy Dallaire, Robin A. Libove, Jennifer M. Phillips, Allis S. Chien, Joseph P. Garner, Antonio Y. Hardan and Karen J. Parker

    Citation: Molecular Autism 2018 9:18

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  32. Content type: Research

    The male predominance in the prevalence of autism spectrum disorder (ASD) has motivated research on sex differentiation in ASD. Multiple sources of evidence have suggested a neurophenotypic convergence of ASD-...

    Authors: Dorothea L. Floris, Meng-Chuan Lai, Tanmay Nath, Michael P. Milham and Adriana Di Martino

    Citation: Molecular Autism 2018 9:17

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  33. Content type: Research

    Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication, and restricted, repetitive behaviors and interests. ...

    Authors: Federica Filice, Emanuel Lauber, Karl Jakob Vörckel, Markus Wöhr and Beat Schwaller

    Citation: Molecular Autism 2018 9:15

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  34. Content type: Research

    Deficits in motor movement in children with autism spectrum disorder (ASD) have typically been characterized qualitatively by human observers. Although clinicians have noted the importance of atypical head pos...

    Authors: Katherine B. Martin, Zakia Hammal, Gang Ren, Jeffrey F. Cohn, Justine Cassell, Mitsunori Ogihara, Jennifer C. Britton, Anibal Gutierrez and Daniel S. Messinger

    Citation: Molecular Autism 2018 9:14

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  35. Content type: Research

    Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognitio...

    Authors: Stavros Stivaros, Shruti Garg, Maria Tziraki, Ying Cai, Owen Thomas, Joseph Mellor, Andrew A. Morris, Carly Jim, Karolina Szumanska-Ryt, Laura M Parkes, Hamied A. Haroon, Daniela Montaldi, Nicholas Webb, John Keane, Francisco X. Castellanos, Alcino J. Silva…

    Citation: Molecular Autism 2018 9:12

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  36. Content type: Research

    Clinical chemistry tests for autism spectrum disorder (ASD) are currently unavailable. The aim of this study was to explore the diagnostic utility of proteotoxic biomarkers in plasma and urine, plasma protein ...

    Authors: Attia Anwar, Provvidenza Maria Abruzzo, Sabah Pasha, Kashif Rajpoot, Alessandra Bolotta, Alessandro Ghezzo, Marina Marini, Annio Posar, Paola Visconti, Paul J. Thornalley and Naila Rabbani

    Citation: Molecular Autism 2018 9:3

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  37. Content type: Research

    Impaired social interaction is one of the essential features of autism spectrum disorder (ASD). Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. One of the ...

    Authors: Dai-Hua Lu, Hsiao-Mei Liao, Chia-Hsiang Chen, Huang-Ju Tu, Houng-Chi Liou, Susan Shur-Fen Gau and Wen-Mei Fu

    Citation: Molecular Autism 2018 9:11

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  38. Content type: Research

    One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced f...

    Authors: Bart Boets, Lien Van Eylen, Kevin Sitek, Pieter Moors, Ilse Noens, Jean Steyaert, Stefan Sunaert and Johan Wagemans

    Citation: Molecular Autism 2018 9:10

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  39. Content type: Research

    Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates a...

    Authors: Gregor Kohls, Ligia Antezana, Maya G. Mosner, Robert T. Schultz and Benjamin E. Yerys

    Citation: Molecular Autism 2018 9:9

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  40. Content type: Research

    Sleep difficulties are prevalent in children with autism spectrum disorder (ASD). The temporal nature of the association between sleep problems and ASD is unclear because longitudinal studies are lacking. Our ...

    Authors: Maria E. Verhoeff, Laura M. E. Blanken, Desana Kocevska, Viara R. Mileva-Seitz, Vincent W. V. Jaddoe, Tonya White, Frank Verhulst, Maartje P. C. M. Luijk and Henning Tiemeier

    Citation: Molecular Autism 2018 9:8

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  41. Content type: Research

    Impairments in social communication are a core feature of Autism Spectrum Disorder (ASD). Because the ability to infer other people’s emotions from their facial expressions is critical for many aspects of soci...

    Authors: E. Loth, L. Garrido, J. Ahmad, E. Watson, A. Duff and B. Duchaine

    Citation: Molecular Autism 2018 9:7

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  42. Content type: Research

    The inability to analyze gene expression in living neurons from Angelman (AS) and Duplication 15q (Dup15q) syndrome subjects has limited our understanding of these disorders at the molecular level.

    Authors: Nora Urraca, Kevin Hope, A. Kaitlyn Victor, T. Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh T. Tran, Silvia Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges and Lawrence T. Reiter

    Citation: Molecular Autism 2018 9:6

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