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  1. Research

    Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome

    Studies in the fmr1 KO mouse demonstrate hyper-excitability and increased high-frequency neuronal activity in sensory cortex. These abnormalities may contribute to prominent and distressing sensory hypersensitivi...

    Lauren E. Ethridge, Stormi P. White, Matthew W. Mosconi, Jun Wang, Ernest V. Pedapati, Craig A. Erickson, Matthew J. Byerly and John A. Sweeney

    Molecular Autism 2017 8:22

    Published on: 7 June 2017

    The Erratum to this article has been published in Molecular Autism 2017 8:38

  2. Research

    A few of my favorite things: circumscribed interests in autism are not accompanied by increased attentional salience on a personalized selective attention task

    Autistic individuals commonly show circumscribed or “special” interests: areas of obsessive interest in a specific category. The present study investigated what impact these interests have on attention, an asp...

    Owen E. Parsons, Andrew P. Bayliss and Anna Remington

    Molecular Autism 2017 8:20

    Published on: 12 April 2017

  3. Research

    Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development

    Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subjec...

    Evie Stergiakouli, George Davey Smith, Joanna Martin, David H. Skuse, Wolfgang Viechtbauer, Susan M. Ring, Angelica Ronald, David E. Evans, Simon E. Fisher, Anita Thapar and Beate St Pourcain

    Molecular Autism 2017 8:18

    Published on: 4 April 2017

  4. Research

    Neurogenetic analysis of childhood disintegrative disorder

    Childhood disintegrative disorder (CDD) is a rare form of autism spectrum disorder (ASD) of unknown etiology. It is characterized by late-onset regression leading to significant intellectual disability (ID) an...

    Abha R. Gupta, Alexander Westphal, Daniel Y. J. Yang, Catherine A. W. Sullivan, Jeffrey Eilbott, Samir Zaidi, Avery Voos, Brent C. Vander Wyk, Pam Ventola, Zainulabedin Waqar, Thomas V. Fernandez, A. Gulhan Ercan-Sencicek, Michael F. Walker, Murim Choi, Allison Schneider, Tammy Hedderly…

    Molecular Autism 2017 8:19

    Published on: 4 April 2017

  5. Research

    Transcriptome analysis of microglia in a mouse model of Rett syndrome: differential expression of genes associated with microglia/macrophage activation and cellular stress

    Rett syndrome (RTT) is a severe, neurodevelopmental disorder primarily affecting girls, characterized by progressive loss of cognitive, social, and motor skills after a relatively brief period of typical devel...

    Dejian Zhao, Ryan Mokhtari, Erika Pedrosa, Rayna Birnbaum, Deyou Zheng and Herbert M. Lachman

    Molecular Autism 2017 8:17

    Published on: 29 March 2017

  6. Research

    Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism

    Autism spectrum disorder (ASD) is one of the most highly heritable neuropsychiatric disorders, but underlying molecular mechanisms are still unresolved due to extreme locus heterogeneity. Leveraging meaningful...

    Rui Chen, Lea K. Davis, Stephen Guter, Qiang Wei, Suma Jacob, Melissa H. Potter, Nancy J. Cox, Edwin H. Cook, James S. Sutcliffe and Bingshan Li

    Molecular Autism 2017 8:14

    Published on: 21 March 2017

  7. Research

    CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells

    CHD8 (chromodomain helicase DNA-binding protein 8), which codes for a member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the most commonly mutated genes ...

    Ping Wang, Ryan Mokhtari, Erika Pedrosa, Michael Kirschenbaum, Can Bayrak, Deyou Zheng and Herbert M. Lachman

    Molecular Autism 2017 8:11

    Published on: 20 March 2017

  8. Research

    Clinical evaluation of autistic symptoms in women with anorexia nervosa

    Despite a suggested link between anorexia nervosa (AN) and autism spectrum disorder (ASD), previous studies have used self-report or diagnostic criteria to assess for ASD in AN populations, rather than direct ...

    Heather Westwood, William Mandy and Kate Tchanturia

    Molecular Autism 2017 8:12

    Published on: 16 March 2017

  9. Research

    Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study

    Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by difficulties in social communication, unusually restricted, repetitive behavior and interests, and specific abnormalities in lang...

    Dominique Endres, Ludger Tebartz van Elst, Simon A. Meyer, Bernd Feige, Kathrin Nickel, Anna Bubl, Andreas Riedel, Dieter Ebert, Thomas Lange, Volkmar Glauche, Monica Biscaldi, Alexandra Philipsen, Simon J. Maier and Evgeniy Perlov

    Molecular Autism 2017 8:10

    Published on: 7 March 2017

  10. Research

    Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism

    Restricted and repetitive behaviors are defining features of autism spectrum disorder (ASD). Under revised diagnostic criteria for ASD, this behavioral domain now includes atypical responses to sensory stimuli...

    Jason J. Wolff, Meghan R. Swanson, Jed T. Elison, Guido Gerig, John R. Pruett Jr., Martin A. Styner, Clement Vachet, Kelly N. Botteron, Stephen R. Dager, Annette M. Estes, Heather C. Hazlett, Robert T. Schultz, Mark D. Shen, Lonnie Zwaigenbaum and Joseph Piven

    Molecular Autism 2017 8:8

    Published on: 4 March 2017

  11. Research

    Disconnection from others in autism is more than just a feeling: whole-brain neural synchrony in adults during implicit processing of emotional faces

    Socio-emotional difficulties in autism spectrum disorder (ASD) are thought to reflect impaired functional connectivity within the “social brain”. Nonetheless, a whole-brain characterization of the fast respons...

    Rocco Mennella, Rachel C. Leung, Margot J. Taylor and Benjamin T. Dunkley

    Molecular Autism 2017 8:7

    Published on: 22 February 2017

  12. Research

    Exaggerated CpH methylation in the autism-affected brain

    The etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the develop...

    Shannon E. Ellis, Simone Gupta, Anna Moes, Andrew B. West and Dan E. Arking

    Molecular Autism 2017 8:6

    Published on: 17 February 2017

  13. Short Report

    Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain

    Autism spectrum disorder (ASD) is sexually dimorphic in brain structure, genetics, and behaviors. In studies of brain tissue, the age of the population is clearly a factor in interpreting study outcome, yet se...

    Cynthia M. Schumann, Frank R. Sharp, Bradley P. Ander and Boryana Stamova

    Molecular Autism 2017 8:4

    Published on: 7 February 2017

  14. Research

    Umbilical cord blood androgen levels and ASD-related phenotypes at 12 and 36 months in an enriched risk cohort study

    Autism spectrum disorder (ASD) affects more than 1% of children in the USA. The male-to-female prevalence ratio of roughly 4:1 in ASD is a well-recognized but poorly understood phenomenon. An explicit focus on...

    Bo Y. Park, Brian K. Lee, Igor Burstyn, Loni P. Tabb, Jeff A. Keelan, Andrew J. O. Whitehouse, Lisa A. Croen, Margaret D. Fallin, Irva Hertz-Picciotto, Owen Montgomery and Craig J. Newschaffer

    Molecular Autism 2017 8:3

    Published on: 31 January 2017

  15. Research

    d-Cycloserine enhances durability of social skills training in autism spectrum disorder

    d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conduct...

    Logan K. Wink, Noha F. Minshawi, Rebecca C. Shaffer, Martin H. Plawecki, David J. Posey, Paul S. Horn, Ryan Adams, Ernest V. Pedapati, Tori L. Schaefer, Christopher J. McDougle, Naomi B. Swiezy and Craig A. Erickson

    Molecular Autism 2017 8:2

    Published on: 25 January 2017

  16. Research

    Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study

    The causes of autism likely involve genetic and environmental factors that influence neurobiological changes and the neurological and behavioral features of the disorder. Immune factors and inflammation are hy...

    Carlos A. Pardo, Cristan A. Farmer, Audrey Thurm, Fatma M. Shebl, Jorjetta Ilieva, Simran Kalra and Susan Swedo

    Molecular Autism 2017 8:1

    Published on: 5 January 2017

  17. Research

    Basic and complex emotion recognition in children with autism: cross-cultural findings

    Children with autism spectrum conditions (ASC) have emotion recognition deficits when tested in different expression modalities (face, voice, body). However, these findings usually focus on basic emotions, usi...

    Shimrit Fridenson-Hayo, Steve Berggren, Amandine Lassalle, Shahar Tal, Delia Pigat, Sven Bölte, Simon Baron-Cohen and Ofer Golan

    Molecular Autism 2016 7:52

    Published on: 19 December 2016

  18. Research

    Placental methylome analysis from a prospective autism study

    Autism spectrum disorders (ASD) are increasingly prevalent neurodevelopmental disorders that are behaviorally diagnosed in early childhood. Most ASD cases likely arise from a complex mixture of genetic and env...

    Diane I. Schroeder, Rebecca J. Schmidt, Florence K. Crary-Dooley, Cheryl K. Walker, Sally Ozonoff, Daniel J. Tancredi, Irva Hertz-Picciotto and Janine M. LaSalle

    Molecular Autism 2016 7:51

    Published on: 15 December 2016

  19. Research

    Bengali translation and characterisation of four cognitive and trait measures for autism spectrum conditions in India

    Autism is characterised by atypical social-communicative behaviour and restricted range of interests and repetitive behaviours. These features exist in a continuum in the general population. Behavioural measur...

    Alokananda Rudra, Jai Ranjan Ram, Tom Loucas, Matthew K. Belmonte and Bhismadev Chakrabarti

    Molecular Autism 2016 7:50

    Published on: 3 December 2016

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