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  1. Content type: Research

    Autism spectrum disorder (ASD) is characterized by impaired social interactions and repetitive patterns of behavior. Symptoms appear in early life and persist throughout adulthood. Early social stimulation can...

    Authors: Marcos Campolongo, Nadia Kazlauskas, German Falasco, Leandro Urrutia, Natalí Salgueiro, Christian Höcht and Amaicha Mara Depino

    Citation: Molecular Autism 2018 9:36

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  2. Content type: Research

    Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterat...

    Authors: Stephen Bent, Brittany Lawton, Tracy Warren, Felicia Widjaja, Katherine Dang, Jed W. Fahey, Brian Cornblatt, Jason M. Kinchen, Kevin Delucchi and Robert L. Hendren

    Citation: Molecular Autism 2018 9:35

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  3. Content type: Research

    Past studies have shown that robot-based intervention was effective in improving gestural use in children with autism spectrum disorders (ASD). The present study examined whether children with ASD could catch ...

    Authors: Wing-Chee So, Miranda Kit-Yi Wong, Wan-Yi Lam, Chun-Ho Cheng, Jia-Hao Yang, Ying Huang, Phoebe Ng, Wai-Leung Wong, Chiu-Lok Ho, Kit-Ling Yeung and Cheuk-Chi Lee

    Citation: Molecular Autism 2018 9:34

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  4. Content type: Research

    Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. Individuals with AS...

    Authors: Hanna den Bakker, Michael S. Sidorov, Zheng Fan, David J. Lee, Lynne M. Bird, Catherine J. Chu and Benjamin D. Philpot

    Citation: Molecular Autism 2018 9:32

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  5. Content type: Research

    Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by psychiatric and neurological features. Most reported cases are caused by 22q13.3 deletions, leading to SHANK3 haploinsufficiency, b...

    Authors: Silvia De Rubeis, Paige M. Siper, Allison Durkin, Jordana Weissman, François Muratet, Danielle Halpern, Maria del Pilar Trelles, Yitzchak Frank, Reymundo Lozano, A. Ting Wang, J. Lloyd Holder Jr, Catalina Betancur, Joseph D. Buxbaum and Alexander Kolevzon

    Citation: Molecular Autism 2018 9:31

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  6. Content type: Research

    Mercury (Hg) has been suspected of causing autism in the past, especially a suspected link with vaccinations containing thiomersal, but a review of the literature shows that has been largely repudiated. Of mor...

    Authors: Jean Golding, Dheeraj Rai, Steven Gregory, Genette Ellis, Alan Emond, Yasmin Iles-Caven, Joseph Hibbeln and Caroline Taylor

    Citation: Molecular Autism 2018 9:30

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  7. Content type: Research

    Alu elements are a group of repetitive elements that can influence gene expression through CpG residues and transcription factor binding. Altered gene expression and methylation profiles have been reported in ...

    Authors: Thanit Saeliw, Chayanin Tangsuwansri, Surangrat Thongkorn, Weerasak Chonchaiya, Kanya Suphapeetiporn, Apiwat Mutirangura, Tewin Tencomnao, Valerie W. Hu and Tewarit Sarachana

    Citation: Molecular Autism 2018 9:27

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  8. Content type: Letter to the Editor

    EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Pr...

    Authors: Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K. Buitelaar, Eva Loth, Declan G. M. Murphy, Will Spooren and Sven Bölte

    Citation: Molecular Autism 2018 9:26

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  9. Content type: Research

    The serotonin (5-HT) system has long been implicated in autism spectrum disorder (ASD) as indicated by elevated whole blood and platelet 5-HT, altered platelet and brain receptor and transporter binding, and g...

    Authors: Jacob Ellegood, Yohan Yee, Travis M. Kerr, Christopher L. Muller, Randy D. Blakely, R. Mark Henkelman, Jeremy Veenstra-VanderWeele and Jason P. Lerch

    Citation: Molecular Autism 2018 9:24

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  10. Content type: Research

    Human genetic and genomic studies have supported a strong causal role of SHANK3 deficiency in autism spectrum disorder (ASD). However, the molecular mechanism underlying SHANK3 deficiency resulting in ASD is not ...

    Authors: Chun-xue Liu, Chun-yang Li, Chun-chun Hu, Yi Wang, Jia Lin, Yong-hui Jiang, Qiang Li and Xiu Xu

    Citation: Molecular Autism 2018 9:23

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  11. Content type: Research

    Sensory abnormalities and sleep disturbances are highly prevalent in children with autism, but the potential relationship between these two domains has rarely been explored. Understanding such relationships is...

    Authors: Orna Tzischinsky, Gal Meiri, Liora Manelis, Asif Bar-Sinai, Hagit Flusser, Analya Michaelovski, Orit Zivan, Michal Ilan, Michal Faroy, Idan Menashe and Ilan Dinstein

    Citation: Molecular Autism 2018 9:22

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  12. Content type: Short report

    Studies have investigated the risk of autism spectrum disorder (ASD) in children exposed in utero to antidepressant, with inconsistent results. Given the substantial public health implications on this topic, h...

    Authors: Xi-Hong Zhou, Yong-Jiang Li, Jian-Jun Ou and Ya-Min Li

    Citation: Molecular Autism 2018 9:21

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  13. Content type: Research

    Haploinsufficiency of the class I bHLH transcription factor TCF4 causes Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants in the TCF4 gene have been identified as susceptib...

    Authors: Matthias Jung, Benjamin M. Häberle, Tristan Tschaikowsky, Marie-Theres Wittmann, Elli-Anna Balta, Vivien-Charlott Stadler, Christiane Zweier, Arnd Dörfler, Christian Johannes Gloeckner and D. Chichung Lie

    Citation: Molecular Autism 2018 9:20

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  14. Content type: Research

    The wide range of ability and disability in ASD creates a need for tools that parse the phenotypic heterogeneity into meaningful subtypes. Using eye tracking, our past studies revealed that when presented with...

    Authors: Adrienne Moore, Madeline Wozniak, Andrew Yousef, Cindy Carter Barnes, Debra Cha, Eric Courchesne and Karen Pierce

    Citation: Molecular Autism 2018 9:19

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  15. Content type: Short report

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD ...

    Authors: Debra S. Karhson, Karolina M. Krasinska, Jamie Ahloy Dallaire, Robin A. Libove, Jennifer M. Phillips, Allis S. Chien, Joseph P. Garner, Antonio Y. Hardan and Karen J. Parker

    Citation: Molecular Autism 2018 9:18

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  16. Content type: Research

    The male predominance in the prevalence of autism spectrum disorder (ASD) has motivated research on sex differentiation in ASD. Multiple sources of evidence have suggested a neurophenotypic convergence of ASD-...

    Authors: Dorothea L. Floris, Meng-Chuan Lai, Tanmay Nath, Michael P. Milham and Adriana Di Martino

    Citation: Molecular Autism 2018 9:17

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  17. Content type: Research

    Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by two core symptoms: impaired social interaction and communication, and restricted, repetitive behaviors and interests. ...

    Authors: Federica Filice, Emanuel Lauber, Karl Jakob Vörckel, Markus Wöhr and Beat Schwaller

    Citation: Molecular Autism 2018 9:15

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  18. Content type: Research

    Deficits in motor movement in children with autism spectrum disorder (ASD) have typically been characterized qualitatively by human observers. Although clinicians have noted the importance of atypical head pos...

    Authors: Katherine B. Martin, Zakia Hammal, Gang Ren, Jeffrey F. Cohn, Justine Cassell, Mitsunori Ogihara, Jennifer C. Britton, Anibal Gutierrez and Daniel S. Messinger

    Citation: Molecular Autism 2018 9:14

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  19. Content type: Research

    Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognitio...

    Authors: Stavros Stivaros, Shruti Garg, Maria Tziraki, Ying Cai, Owen Thomas, Joseph Mellor, Andrew A. Morris, Carly Jim, Karolina Szumanska-Ryt, Laura M Parkes, Hamied A. Haroon, Daniela Montaldi, Nicholas Webb, John Keane, Francisco X. Castellanos, Alcino J. Silva…

    Citation: Molecular Autism 2018 9:12

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  20. Content type: Research

    Clinical chemistry tests for autism spectrum disorder (ASD) are currently unavailable. The aim of this study was to explore the diagnostic utility of proteotoxic biomarkers in plasma and urine, plasma protein ...

    Authors: Attia Anwar, Provvidenza Maria Abruzzo, Sabah Pasha, Kashif Rajpoot, Alessandra Bolotta, Alessandro Ghezzo, Marina Marini, Annio Posar, Paola Visconti, Paul J. Thornalley and Naila Rabbani

    Citation: Molecular Autism 2018 9:3

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  21. Content type: Research

    Impaired social interaction is one of the essential features of autism spectrum disorder (ASD). Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. One of the ...

    Authors: Dai-Hua Lu, Hsiao-Mei Liao, Chia-Hsiang Chen, Huang-Ju Tu, Houng-Chi Liou, Susan Shur-Fen Gau and Wen-Mei Fu

    Citation: Molecular Autism 2018 9:11

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  22. Content type: Research

    One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced f...

    Authors: Bart Boets, Lien Van Eylen, Kevin Sitek, Pieter Moors, Ilse Noens, Jean Steyaert, Stefan Sunaert and Johan Wagemans

    Citation: Molecular Autism 2018 9:10

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  23. Content type: Research

    Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates a...

    Authors: Gregor Kohls, Ligia Antezana, Maya G. Mosner, Robert T. Schultz and Benjamin E. Yerys

    Citation: Molecular Autism 2018 9:9

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  24. Content type: Research

    Sleep difficulties are prevalent in children with autism spectrum disorder (ASD). The temporal nature of the association between sleep problems and ASD is unclear because longitudinal studies are lacking. Our ...

    Authors: Maria E. Verhoeff, Laura M. E. Blanken, Desana Kocevska, Viara R. Mileva-Seitz, Vincent W. V. Jaddoe, Tonya White, Frank Verhulst, Maartje P. C. M. Luijk and Henning Tiemeier

    Citation: Molecular Autism 2018 9:8

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  25. Content type: Research

    Impairments in social communication are a core feature of Autism Spectrum Disorder (ASD). Because the ability to infer other people’s emotions from their facial expressions is critical for many aspects of soci...

    Authors: E. Loth, L. Garrido, J. Ahmad, E. Watson, A. Duff and B. Duchaine

    Citation: Molecular Autism 2018 9:7

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  26. Content type: Research

    The inability to analyze gene expression in living neurons from Angelman (AS) and Duplication 15q (Dup15q) syndrome subjects has limited our understanding of these disorders at the molecular level.

    Authors: Nora Urraca, Kevin Hope, A. Kaitlyn Victor, T. Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh T. Tran, Silvia Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges and Lawrence T. Reiter

    Citation: Molecular Autism 2018 9:6

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  27. Content type: Research

    Genetic mosaicism is only detected occasionally when there are no obvious health or developmental issues. Most cases concern healthy parents in whom mosaicism is identified upon targeted testing of a genetic d...

    Authors: Anneke de Boer, Karlijn Vermeulen, Jos I. M. Egger, Joost G. E. Janzing, Nicole de Leeuw, Hermine E. Veenstra-Knol, Nicolette S. den Hollander, Hans van Bokhoven, Wouter Staal and Tjitske Kleefstra

    Citation: Molecular Autism 2018 9:5

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  28. Content type: Research

    Autism spectrum disorder and epilepsy often co-occur; however, the extent to which the association between autism symptoms and epilepsy is due to shared aetiology or to the direct effects of seizures is a topi...

    Authors: Kristin A. Bakke, Patricia Howlin, Lars Retterstøl, Øivind J. Kanavin, Arvid Heiberg and Terje Nærland

    Citation: Molecular Autism 2018 9:2

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  29. Content type: Research

    Macrocephaly, which is defined as a head circumference greater than or equal to + 2 standard deviations, is a feature commonly observed in children with developmental delay and/or autism spectrum disorder. Alt...

    Authors: Kit San Yeung, Winnie Wan Yee Tso, Janice Jing Kun Ip, Christopher Chun Yu Mak, Gordon Ka Chun Leung, Mandy Ho Yin Tsang, Dingge Ying, Steven Lim Cho Pei, So Lun Lee, Wanling Yang and Brian Hon-Yin Chung

    Citation: Molecular Autism 2017 8:66

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  30. Content type: Research

    Autism spectrum disorder (ASD) diagnosis can be delayed due in part to the time required for administration of standard exams, such as the Autism Diagnostic Observation Schedule (ADOS). Shorter and potentially...

    Authors: Sebastien Levy, Marlena Duda, Nick Haber and Dennis P. Wall

    Citation: Molecular Autism 2017 8:65

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  31. Content type: Short report

    While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes has not been conducted. Such an investigation is further warranted by an increasing role for...

    Authors: Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall and Gursharan Chana

    Citation: Molecular Autism 2017 8:64

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  32. Content type: Research

    Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding...

    Authors: Anne Masi, Edmond J. Breen, Gail A. Alvares, Nicholas Glozier, Ian B. Hickie, Anna Hunt, Jennie Hui, John Beilby, David Ravine, John Wray, Andrew J. O. Whitehouse and Adam J. Guastella

    Citation: Molecular Autism 2017 8:63

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  33. Content type: Research

    Prospective studies of infants at familial risk for autism spectrum disorder (ASD) have yielded insights into the earliest signs of the disorder but represent heterogeneous samples of unclear aetiology. Comple...

    Authors: Anna May Kolesnik, Emily Jane Harrison Jones, Shruti Garg, Jonathan Green, Tony Charman and Mark Henry Johnson

    Citation: Molecular Autism 2017 8:62

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  34. Content type: Research

    Individuals with autism spectrum disorder (ASD) frequently demonstrate symptoms of attention-deficit/hyperactivity disorder (ADHD). Previous findings in children with ASD have suggested that these symptoms are...

    Authors: Steve Lukito, Catherine R. G. Jones, Andrew Pickles, Gillian Baird, Francesca Happé, Tony Charman and Emily Simonoff

    Citation: Molecular Autism 2017 8:60

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  35. Content type: Research

    Autism spectrum disorder (ASD), a developmental disorder of early childhood onset, affects males four times more frequently than females, suggesting a role for the sex chromosomes. In this study, we describe a...

    Authors: Marc Woodbury-Smith, Eric Deneault, Ryan K. C. Yuen, Susan Walker, Mehdi Zarrei, Giovanna Pellecchia, Jennifer L. Howe, Ny Hoang, Mohammed Uddin, Christian R. Marshall, Christina Chrysler, Ann Thompson, Peter Szatmari and Stephen W. Scherer

    Citation: Molecular Autism 2017 8:59

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  36. Content type: Research

    Previous studies have reported no clear critical region for medical comorbidities in children with deletions or duplications of 22q11.2. The purpose of this study was to evaluate whether individuals with small...

    Authors: Caitlin C. Clements, Tara L. Wenger, Alisa R. Zoltowski, Jennifer R. Bertollo, Judith S. Miller, Ashley B. de Marchena, Lauren M. Mitteer, John C. Carey, Benjamin E. Yerys, Elaine H. Zackai, Beverly S. Emanuel, Donna M. McDonald-McGinn and Robert T. Schultz

    Citation: Molecular Autism 2017 8:58

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  37. Content type: Research

    Haploinsufficiency of the forkhead-box protein P1 (FOXP1) gene leads to a neurodevelopmental disorder termed FOXP1 syndrome. Previous studies in individuals carrying FOXP1 mutations and deletions have described t...

    Authors: Paige M. Siper, Silvia De Rubeis, Maria del Pilar Trelles, Allison Durkin, Daniele Di Marino, François Muratet, Yitzchak Frank, Reymundo Lozano, Evan E. Eichler, Morgan Kelly, Jennifer Beighley, Jennifer Gerdts, Arianne S. Wallace, Heather C. Mefford, Raphael A. Bernier, Alexander Kolevzon…

    Citation: Molecular Autism 2017 8:57

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  38. Content type: Research

    Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 function is derived from transcriptomic studies wit...

    Authors: Natasha L. Pacheco, Michael R. Heaven, Leanne M. Holt, David K. Crossman, Kristin J. Boggio, Scott A. Shaffer, Daniel L. Flint and Michelle L. Olsen

    Citation: Molecular Autism 2017 8:56

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  39. Content type: Viewpoint

    Although the number of autism diagnoses is on the rise, we have no evidence-based tracking of size and severity of gaps in access to autism-related resources, nor do we have methods to geographically triangula...

    Authors: Jena Daniels, Jessey Schwartz, Nikhila Albert, Michael Du and Dennis P. Wall

    Citation: Molecular Autism 2017 8:55

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  40. Content type: Research

    DYRK1A is a gene recurrently disrupted in 0.1–0.5% of the ASD population. A growing number of case reports with DYRK1A haploinsufficiency exhibit common phenotypic features including m...

    Authors: Rachel K. Earl, Tychele N. Turner, Heather C. Mefford, Caitlin M. Hudac, Jennifer Gerdts, Evan E. Eichler and Raphael A. Bernier

    Citation: Molecular Autism 2017 8:54

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  41. Content type: Methodology

    Deciphering the biological mechanisms underlying social behavior in animal models requires standard behavioral paradigms that can be unbiasedly employed in an observer- and laboratory-independent manner. Durin...

    Authors: Shai Netser, Shani Haskal, Hen Magalnik and Shlomo Wagner

    Citation: Molecular Autism 2017 8:53

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