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  1. Current global estimates suggest the proportion of the population with autism spectrum disorder (ASD) who have intellectual disability (ID) is approximately 50%. Our objective was to ascertain the existence of...

    Authors: Ginny Russell, William Mandy, Daisy Elliott, Rhianna White, Tom Pittwood and Tamsin Ford

    Citation: Molecular Autism 2019 10:9

    Content type: Review

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  2. Of the many genetic mutations known to increase the risk of autism spectrum disorder, a large proportion cluster upon synaptic proteins. One such family of presynaptic proteins are the neurexins (NRXN), and re...

    Authors: Eleftheria Pervolaraki, Adam L. Tyson, Francesca Pibiri, Steven L. Poulter, Amy C. Reichelt, R. John Rodgers, Steven J. Clapcote, Colin Lever, Laura C. Andreae and James Dachtler

    Citation: Molecular Autism 2019 10:8

    Content type: Research

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  3. Autism prevalence in the West is approximately 1% of school age children. Autism prevalence in China has been reported to be lower than in the West. This is likely due to at least two reasons: (1) most studies...

    Authors: Xiang Sun, Carrie Allison, Liping Wei, Fiona E. Matthews, Bonnie Auyeung, Yu Yu Wu, Sian Griffiths, Jie Zhang, Simon Baron-Cohen and Carol Brayne

    Citation: Molecular Autism 2019 10:7

    Content type: Research

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  4. Autism spectrum disorders (ASD) exhibit two clusters of core symptoms, i.e., social and communication impairment, and repetitive behaviors and sensory abnormalities. Our previous study demonstrated that TBR1, ...

    Authors: Tzyy-Nan Huang, Tzu-Li Yen, Lily R. Qiu, Hsiu-Chun Chuang, Jason P. Lerch and Yi-Ping Hsueh

    Citation: Molecular Autism 2019 10:5

    Content type: Research

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  5. Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a ...

    Authors: Teresa Tavassoli, Anne Brandes-Aitken, Robyn Chu, Lisa Porter, Sarah Schoen, Lucy Jane Miller, Molly Rae Gerdes, Julia Owen, Pratik Mukherjee and Elysa J. Marco

    Citation: Molecular Autism 2019 10:4

    Content type: Research

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  6. Autism spectrum disorder (ASD) is currently estimated to affect more than 1% of the world population. For people with ASD, gastrointestinal (GI) distress is a commonly reported but a poorly understood co-occur...

    Authors: David M. James, Robert A. Kozol, Yuji Kajiwara, Adam L. Wahl, Emily C. Storrs, Joseph D. Buxbaum, Mason Klein, Baharak Moshiree and Julia E. Dallman

    Citation: Molecular Autism 2019 10:3

    Content type: Research

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  7. The endocannabinoid system (ECS) is a major regulator of synaptic plasticity and neuromodulation. Alterations of the ECS have been demonstrated in several animal models of autism spectrum disorder (ASD). In so...

    Authors: Adi Aran, Maya Eylon, Moria Harel, Lola Polianski, Alina Nemirovski, Sigal Tepper, Aviad Schnapp, Hanoch Cassuto, Nadia Wattad and Joseph Tam

    Citation: Molecular Autism 2019 10:2

    Content type: Research

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  8. Evidence has indicated that some non-inherited factors such as exposure to environmental pollutants are associated with neurodevelopment disorders like autism spectrum disorder (ASD). Studies report that endoc...

    Authors: Manhai Long, Mandana Ghisari, Lisbeth Kjeldsen, Maria Wielsøe, Bent Nørgaard-Pedersen, Erik Lykke Mortensen, Morsi W. Abdallah and Eva C. Bonefeld-Jørgensen

    Citation: Molecular Autism 2019 10:1

    Content type: Research

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  9. Functional neuroimaging research in autism spectrum disorder has reported patterns of decreased long-range, within-network, and interhemispheric connectivity. Research has also reported increased corticostriat...

    Authors: Terisa P. Gabrielsen, Jeff S. Anderson, Kevin G. Stephenson, Jonathan Beck, Jace B. King, Ryan Kellems, David N. Top Jr, Nicholas C. C. Russell, Emily Anderberg, Rebecca A. Lundwall, Blake Hansen and Mikle South

    Citation: Molecular Autism 2018 9:67

    Content type: Research

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  10. Neuroglial cells that provide homeostatic support and form defence of the nervous system contribute to all neurological disorders. We analyzed three major types of neuroglia, astrocytes, oligodendrocytes, and ...

    Authors: Maria Rosanna Bronzuoli, Roberta Facchinetti, Davide Ingrassia, Michela Sarvadio, Sara Schiavi, Luca Steardo, Alexei Verkhratsky, Viviana Trezza and Caterina Scuderi

    Citation: Molecular Autism 2018 9:66

    Content type: Research

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  11. Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings in genetic studies of autism spectrum disorder (ASD). The CHD8 protein is believed to act as a tra...

    Authors: Qiong Xu, Yuan-yuan Liu, Xiaoming Wang, Guo-he Tan, Hui-ping Li, Samuel W. Hulbert, Chun-yang Li, Chun-chun Hu, Zhi-qi Xiong, Xiu Xu and Yong-hui Jiang

    Citation: Molecular Autism 2018 9:65

    Content type: Research

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  12. We previously performed targeted sequencing of autism risk genes in probands from the Autism Clinical and Genetic Resources in China (ACGC) (phase I). Here, we expand this analysis to a larger cohort of patien...

    Authors: Hui Guo, Tianyun Wang, Huidan Wu, Min Long, Bradley P. Coe, Honghui Li, Guanglei Xun, Jianjun Ou, Biyuan Chen, Guiqin Duan, Ting Bai, Ningxia Zhao, Yidong Shen, Yun Li, Yazhe Wang, Yu Zhang…

    Citation: Molecular Autism 2018 9:64

    Content type: Research

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  13. Animal models for neurodevelopmental disorders (NDD) generally rely on a single genetic mutation on a fixed genetic background. Recent human genetic studies however indicate that a clinical diagnosis with Auti...

    Authors: Remco T. Molenhuis, Hilgo Bruining, Myrna J. V. Brandt, Petra E. van Soldt, Hanifa J. Abu-Toamih Atamni, J. Peter H. Burbach, Fuad A. Iraqi, Richard F. Mott and Martien J. H. Kas

    Citation: Molecular Autism 2018 9:63

    Content type: Research

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  14. The corpus callosum is implicated in the pathophysiology of autism spectrum disorder (ASD). However, specific structural deficits and underlying mechanisms are yet to be well defined.

    Authors: Yu Veronica Sui, Jeffrey Donaldson, Laura Miles, James S. Babb, Francisco Xavier Castellanos and Mariana Lazar

    Citation: Molecular Autism 2018 9:62

    Content type: Research

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  15. Gut microbiota has the capacity to impact the regular function of the brain, which can in turn affect the composition of microbiota. Autism spectrum disorder (ASD) patients suffer from gastrointestinal problem...

    Authors: Fang Liu, Kayla Horton-Sparks, Vanessa Hull, Robert W. Li and Verónica Martínez-Cerdeño

    Citation: Molecular Autism 2018 9:61

    Content type: Research

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  16. Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD ...

    Authors: Miho Tanaka, Atsushi Sato, Shinya Kasai, Yoko Hagino, Hiroko Kotajima-Murakami, Hirofumi Kashii, Yukio Takamatsu, Yasumasa Nishito, Masumi Inagaki, Masashi Mizuguchi, F. Scott Hall, George R. Uhl, Dennis Murphy, Ichiro Sora and Kazutaka Ikeda

    Citation: Molecular Autism 2018 9:60

    Content type: Research

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  17. Pioglitazone is a promising compound for treatment of core autism spectrum disorder (ASD) symptoms as it targets multiple relevant pathways, including immune system alterations.

    Authors: Lucia Capano, Annie Dupuis, Jessica Brian, Deepali Mankad, Lisa Genore, Rianne Hastie Adams, Sharon Smile, Toni Lui, Dina Odrobina, Jane A. Foster and Evdokia Anagnostou

    Citation: Molecular Autism 2018 9:59

    Content type: Research

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  18. The majority of previous research into restricted and repetitive behaviours (RRBs) has focussed on children, partly due to a lack of suitable measures for RRBs in adults. This study aimed to explore the psycho...

    Authors: Sarah L. Barrett, Mirko Uljarević, Catherine R. G. Jones and Susan R. Leekam

    Citation: Molecular Autism 2018 9:58

    Content type: Short report

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  19. Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by three core symptoms that include social interaction deficits, cognitive inflexibility, and communication disorders. They have b...

    Authors: Nisim Perets, Stav Hertz, Michael London and Daniel Offen

    Citation: Molecular Autism 2018 9:57

    Content type: Research

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  20. Altered neuronal development is discussed as the underlying pathogenic mechanism of autism spectrum disorders (ASD). Copy number variations of 16p11.2 have recurrently been identified in individuals with ASD. ...

    Authors: Denise Haslinger, Regina Waltes, Afsheen Yousaf, Silvia Lindlar, Ines Schneider, Chai K. Lim, Meng-Miao Tsai, Boyan K. Garvalov, Amparo Acker-Palmer, Nicolas Krezdorn, Björn Rotter, Till Acker, Gilles J. Guillemin, Simone Fulda, Christine M. Freitag and Andreas G. Chiocchetti

    Citation: Molecular Autism 2018 9:56

    Content type: Research

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  21. There is a global need for brief screening instruments that can identify key indicators for autism to support frontline professionals in their referral decision-making. Although a universal set of conditions, ...

    Authors: Sophie Carruthers, Emma Kinnaird, Alokananda Rudra, Paula Smith, Carrie Allison, Bonnie Auyeung, Bhismadev Chakrabarti, Akio Wakabayashi, Simon Baron-Cohen, Ioannis Bakolis and Rosa A Hoekstra

    Citation: Molecular Autism 2018 9:52

    Content type: Research

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  22. Loss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be lea...

    Authors: Alain C. Burette, Matthew C. Judson, Alissa N. Li, Edward F. Chang, William W. Seeley, Benjamin D. Philpot and Richard J. Weinberg

    Citation: Molecular Autism 2018 9:54

    Content type: Research

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  23. Savant syndrome is a condition where prodigious talent can co-occur with developmental conditions such as autism spectrum conditions (autism). It is not yet clear why some autistic people develop savant skills...

    Authors: James E A Hughes, Jamie Ward, Elin Gruffydd, Simon Baron-Cohen, Paula Smith, Carrie Allison and Julia Simner

    Citation: Molecular Autism 2018 9:53

    Content type: Research

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  24. Rapid automatized naming (RAN; naming of familiar items presented in an array) is a task that taps fundamental neurocognitive processes that are affected in a number of complex psychiatric conditions. Deficits...

    Authors: Kritika Nayar, Peter C Gordon, Gary E Martin, Abigail L Hogan, Chelsea La Valle, Walker McKinney, Michelle Lee, Elizabeth S Norton and Molly Losh

    Citation: Molecular Autism 2018 9:51

    Content type: Research

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  25. Many young people with autism spectrum disorder (ASD) experience emotional and behavioural problems. However, the causes of these co-occurring difficulties are not well understood. Perceptual processing atypic...

    Authors: Virginia Carter Leno, Susie Chandler, Pippa White, Isabel Yorke, Tony Charman, Andrew Pickles and Emily Simonoff

    Citation: Molecular Autism 2018 9:50

    Content type: Research

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  26. Histological evidence suggests that autism spectrum disorder (ASD) is accompanied by a reduced integrity of the grey-white matter boundary. This has also recently been confirmed by a structural neuroimaging st...

    Authors: Caroline Mann, Anke Bletsch, Derek Andrews, Eileen Daly, Clodagh Murphy, Declan Murphy and Christine Ecker

    Citation: Molecular Autism 2018 9:49

    Content type: Research

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  27. Autism spectrum disorders (ASDs) are a heterogeneous group of behaviorally defined disorders and are associated with hundreds of rare genetic mutations and several environmental risk factors. Mouse models of s...

    Authors: Emily A. Brown, Jonathan D. Lautz, Tessa R. Davis, Edward P. Gniffke, Alison A. W. VanSchoiack, Steven C. Neier, Noah Tashbook, Chiara Nicolini, Margaret Fahnestock, Adam G. Schrum and Stephen E. P. Smith

    Citation: Molecular Autism 2018 9:48

    Content type: Research

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  28. Angelman syndrome (AS) is a neurodevelopmental disorder caused by mutations affecting UBE3A function. AS is characterized by intellectual disability, impaired motor coordination, epilepsy, and behavioral abnor...

    Authors: Monica Sonzogni, Ilse Wallaard, Sara Silva Santos, Jenina Kingma, Dorine du Mee, Geeske M. van Woerden and Ype Elgersma

    Citation: Molecular Autism 2018 9:47

    Content type: Research

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  29. A growing body of anecdotal evidence indicates that the use of robots may provide unique opportunities for assisting children with autism spectrum disorders (ASD). However, previous studies investigating the e...

    Authors: Hirokazu Kumazaki, Yuichiro Yoshikawa, Yuko Yoshimura, Takashi Ikeda, Chiaki Hasegawa, Daisuke N. Saito, Sara Tomiyama, Kyung-min An, Jiro Shimaya, Hiroshi Ishiguro, Yoshio Matsumoto, Yoshio Minabe and Mitsuru Kikuchi

    Citation: Molecular Autism 2018 9:46

    Content type: Research

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  30. Angelman syndrome (AS) is a severe neurodevelopmental disorder lacking effective therapies. AS is caused by mutations in ubiquitin protein ligase E3A (UBE3A), which is genomically imprinted such that only the mat...

    Authors: Hyeong-Min Lee, Ellen P. Clark, M. Bram Kuijer, Mark Cushman, Yves Pommier and Benjamin D. Philpot

    Citation: Molecular Autism 2018 9:45

    Content type: Research

    Published on:

  31. Lowe syndrome (LS) is a rare genetic disorder caused by loss of function mutations in the X-linked gene, OCRL, which codes for inositol polyphosphate 5-phosphatase. LS is characterized by the triad of congenital ...

    Authors: Jesse Barnes, Franklin Salas, Ryan Mokhtari, Hedwig Dolstra, Erika Pedrosa and Herbert M. Lachman

    Citation: Molecular Autism 2018 9:44

    Content type: Research

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  32. Recent literatures indicate that maternal hormone exposure is a risk factor for autism spectrum disorder (ASD). We hypothesize that prenatal progestin exposure may counteract the neuroprotective effect of estr...

    Authors: Weiguo Xie, Xiaohu Ge, Ling Li, Athena Yao, Xiaoyan Wang, Min Li, Xiang Gong, Zhigang Chu, Zhe Lu, Xiaodong Huang, Yun Jiao, Yifei Wang, Meifang Xiao, Haijia Chen, Wei Xiang and Paul Yao

    Citation: Molecular Autism 2018 9:43

    Content type: Research

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  33. Research has shown high rates of suicidality in autism spectrum conditions (ASC), but there is lack of research into why this is the case. Many common experiences of autistic adults, such as depression or unemplo...

    Authors: Sarah Cassidy, Louise Bradley, Rebecca Shaw and Simon Baron-Cohen

    Citation: Molecular Autism 2018 9:42

    Content type: Research

    Published on:

  34. Inherited abnormalities of perception, recognition, and attention to faces have been implicated in the etiology of autism spectrum disorders (ASD) including abnormal components of event-related brain potential...

    Authors: Olga V. Sysoeva, John N. Constantino and Andrey P. Anokhin

    Citation: Molecular Autism 2018 9:41

    Content type: Research

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  35. Several reports have suggested a role for epigenetic mechanisms in ASD etiology. Epigenome-wide association studies (EWAS) in autism spectrum disorder (ASD) may shed light on particular biological mechanisms. ...

    Authors: Shan V. Andrews, Brooke Sheppard, Gayle C. Windham, Laura A. Schieve, Diana E. Schendel, Lisa A. Croen, Pankaj Chopra, Reid S. Alisch, Craig J. Newschaffer, Stephen T. Warren, Andrew P. Feinberg, M. Daniele Fallin and Christine Ladd-Acosta

    Citation: Molecular Autism 2018 9:40

    Content type: Short report

    Published on:

  36. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs have emerged as important modulators of brain development and neuronal function and are imp...

    Authors: Lam Son Nguyen, Julien Fregeac, Christine Bole-Feysot, Nicolas Cagnard, Anand Iyer, Jasper Anink, Eleonora Aronica, Olivier Alibeu, Patrick Nitschke and Laurence Colleaux

    Citation: Molecular Autism 2018 9:38

    Content type: Research

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  37. Nausea and vomiting during pregnancy (NVP) is thought to be caused by changes in maternal hormones during pregnancy. Differences in hormone exposure during prenatal life have been implicated in the causal path...

    Authors: Andrew J. O. Whitehouse, Gail A. Alvares, Dominique Cleary, Alexis Harun, Angela Stojanoska, Lauren J. Taylor, Kandice J. Varcin and Murray Maybery

    Citation: Molecular Autism 2018 9:37

    Content type: Research

    Published on:

  38. Autism spectrum disorder (ASD) is characterized by impaired social interactions and repetitive patterns of behavior. Symptoms appear in early life and persist throughout adulthood. Early social stimulation can...

    Authors: Marcos Campolongo, Nadia Kazlauskas, German Falasco, Leandro Urrutia, Natalí Salgueiro, Christian Höcht and Amaicha Mara Depino

    Citation: Molecular Autism 2018 9:36

    Content type: Research

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  39. Children with autism spectrum disorder (ASD) have urinary metabolites suggesting impairments in several pathways, including oxidative stress, inflammation, mitochondrial dysfunction, and gut microbiome alterat...

    Authors: Stephen Bent, Brittany Lawton, Tracy Warren, Felicia Widjaja, Katherine Dang, Jed W. Fahey, Brian Cornblatt, Jason M. Kinchen, Kevin Delucchi and Robert L. Hendren

    Citation: Molecular Autism 2018 9:35

    Content type: Research

    Published on:

  40. Past studies have shown that robot-based intervention was effective in improving gestural use in children with autism spectrum disorders (ASD). The present study examined whether children with ASD could catch ...

    Authors: Wing-Chee So, Miranda Kit-Yi Wong, Wan-Yi Lam, Chun-Ho Cheng, Jia-Hao Yang, Ying Huang, Phoebe Ng, Wai-Leung Wong, Chiu-Lok Ho, Kit-Ling Yeung and Cheuk-Chi Lee

    Citation: Molecular Autism 2018 9:34

    Content type: Research

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  41. Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. Individuals with AS...

    Authors: Hanna den Bakker, Michael S. Sidorov, Zheng Fan, David J. Lee, Lynne M. Bird, Catherine J. Chu and Benjamin D. Philpot

    Citation: Molecular Autism 2018 9:32

    Content type: Research

    Published on:

  42. Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by psychiatric and neurological features. Most reported cases are caused by 22q13.3 deletions, leading to SHANK3 haploinsufficiency, b...

    Authors: Silvia De Rubeis, Paige M. Siper, Allison Durkin, Jordana Weissman, François Muratet, Danielle Halpern, Maria del Pilar Trelles, Yitzchak Frank, Reymundo Lozano, A. Ting Wang, J. Lloyd Holder Jr, Catalina Betancur, Joseph D. Buxbaum and Alexander Kolevzon

    Citation: Molecular Autism 2018 9:31

    Content type: Research

    Published on:

  43. Mercury (Hg) has been suspected of causing autism in the past, especially a suspected link with vaccinations containing thiomersal, but a review of the literature shows that has been largely repudiated. Of mor...

    Authors: Jean Golding, Dheeraj Rai, Steven Gregory, Genette Ellis, Alan Emond, Yasmin Iles-Caven, Joseph Hibbeln and Caroline Taylor

    Citation: Molecular Autism 2018 9:30

    Content type: Research

    Published on:

  44. Alu elements are a group of repetitive elements that can influence gene expression through CpG residues and transcription factor binding. Altered gene expression and methylation profiles have been reported in ...

    Authors: Thanit Saeliw, Chayanin Tangsuwansri, Surangrat Thongkorn, Weerasak Chonchaiya, Kanya Suphapeetiporn, Apiwat Mutirangura, Tewin Tencomnao, Valerie W. Hu and Tewarit Sarachana

    Citation: Molecular Autism 2018 9:27

    Content type: Research

    Published on:

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