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  1. Contrasting findings were reported in several animal models with a Shank3 mutation used to induce various autism spectrum disorder (ASD) symptoms. Here, we aimed at investigating behavioral, cellular, and molecul...

    Authors: Emmanuel Matas, Alexandre Maisterrena, Mathieu Thabault, Eric Balado, Maureen Francheteau, Anais Balbous, Laurie Galvan and Mohamed Jaber

    Citation: Molecular Autism 2021 12:2

    Content type: Research

    Published on:

  2. Gene copy number variants play an important role in the occurrence of neurodevelopmental disorders. Particularly, the deletion of the 16p11.2 locus is associated with autism spectrum disorder, intellectual dis...

    Authors: Sandra Martin Lorenzo, Valérie Nalesso, Claire Chevalier, Marie-Christine Birling and Yann Herault

    Citation: Molecular Autism 2021 12:1

    Content type: Research

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  3. Deficits in perception and production of vocal pitch are often observed in people with autism spectrum disorder (ASD), but the neural basis of these deficits is unknown. In magnetoencephalogram (MEG), spectral...

    Authors: T. A. Stroganova, K. S. Komarov, O. V. Sysoeva, D. E. Goiaeva, T. S. Obukhova, T. M. Ovsiannikova, A. O. Prokofyev and E. V. Orekhova

    Citation: Molecular Autism 2020 11:100

    Content type: Research

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  4. The controlled differentiation of pluripotent stem cells (PSCs) into neurons and glia offers a unique opportunity to study early stages of human central nervous system development under controlled conditions i...

    Authors: Arquimedes Cheffer, Lea Jessica Flitsch, Tamara Krutenko, Pascal Röderer, Liubov Sokhranyaeva, Vira Iefremova, Mohamad Hajo, Michael Peitz, Martin Karl Schwarz and Oliver Brüstle

    Citation: Molecular Autism 2020 11:99

    Content type: Review

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  5. The relationships between specific genetic aetiology and phenotype in neurodevelopmental disorders are complex and hotly contested. Genes associated with intellectual disability (ID) can be grouped into networ...

    Authors: Diandra Brkić, Elise Ng-Cordell, Sinéad O’Brien, Gaia Scerif, Duncan Astle and Kate Baker

    Citation: Molecular Autism 2020 11:98

    Content type: Research

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  6. Children born extremely preterm are at heightened risk for intellectual and social impairment, including Autism Spectrum Disorder (ASD). There is increasing evidence for a key role of the placenta in prenatal ...

    Authors: Hudson P. Santos Jr, Arjun Bhattacharya, Robert M. Joseph, Lisa Smeester, Karl C. K. Kuban, Carmen J. Marsit, T. Michael O’Shea and Rebecca C. Fry

    Citation: Molecular Autism 2020 11:97

    Content type: Research

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  7. Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders which are more common in males. The ‘prenatal sex steroid’ hypothesis links excessive sex-steroid exposure during foetal life with the ...

    Authors: Asad Amanat Ali, Xiaoying Cui, Renata Aparecida Nedel Pertile, Xiang Li, Gregory Medley, Suzanne Adele Alexander, Andrew J. O. Whitehouse, John Joseph McGrath and Darryl Walter Eyles

    Citation: Molecular Autism 2020 11:96

    Content type: Research

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  9. Scanning faces is important for social interactions. Difficulty with the social use of eye contact constitutes one of the clinical symptoms of autism spectrum disorder (ASD). It has been suggested that individ...

    Authors: Sofie Vettori, Stephanie Van der Donck, Jannes Nys, Pieter Moors, Tim Van Wesemael, Jean Steyaert, Bruno Rossion, Milena Dzhelyova and Bart Boets

    Citation: Molecular Autism 2020 11:94

    Content type: Research

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  10. Prenatal exposure to increased androgens has been suggested as a risk factor for autism spectrum disorder (ASD). This hypothesis has been examined by measurement of steroids in amniotic fluid, cord blood, sali...

    Authors: Dina Terloyeva, Alexander J. Frey, Bo Y. Park, Elizabeth M. Kauffman, Leny Mathew, Anna Bostwick, Erika L. Varner, Brian K. Lee, Lisa A. Croen, Margaret D. Fallin, Irva Hertz-Picciotto, Craig J. Newschaffer, Kristen Lyall and Nathaniel W. Snyder

    Citation: Molecular Autism 2020 11:93

    Content type: Research

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  11. The regulation of protein synthesis is a critical step in gene expression, and its dysfunction is implicated in autism spectrum disorder (ASD). The eIF4E homologous protein (4EHP, also termed eIF4E2) binds to ...

    Authors: Shane Wiebe, Xiang Qi Meng, Sung-Hoon Kim, Xu Zhang, Jean-Claude Lacaille, Argel Aguilar-Valles and Nahum Sonenberg

    Citation: Molecular Autism 2020 11:92

    Content type: Research

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  12. Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available. Duplicat...

    Authors: Francesca Cavallo, Flavia Troglio, Giovanni Fagà, Daniele Fancelli, Reinald Shyti, Sebastiano Trattaro, Matteo Zanella, Giuseppe D’Agostino, James M. Hughes, Maria Rosaria Cera, Maurizio Pasi, Michele Gabriele, Maddalena Lazzarin, Marija Mihailovich, Frank Kooy, Alessandro Rosa…

    Citation: Molecular Autism 2020 11:88

    Content type: Research

    Published on:

  13. With the overarching objective to gain better insights into social attention in autistic adults, the present study addresses three outstanding issues about face processing in autism. First, do autistic adults ...

    Authors: Elise Clin, Pauline Maes, Fanny Stercq and Mikhail Kissine

    Citation: Molecular Autism 2020 11:91

    Content type: Research

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  14. The heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neuroco...

    Authors: Shile Qi, Robin Morris, Jessica A. Turner, Zening Fu, Rongtao Jiang, Thomas P. Deramus, Dongmei Zhi, Vince D. Calhoun and Jing Sui

    Citation: Molecular Autism 2020 11:90

    Content type: Research

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  15. Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Alter...

    Authors: Sarah Jacot-Descombes, Neha U. Keshav, Dara L. Dickstein, Bridget Wicinski, William G. M. Janssen, Liam L. Hiester, Edward K. Sarfo, Tahia Warda, Matthew M. Fam, Hala Harony-Nicolas, Joseph D. Buxbaum, Patrick R. Hof and Merina Varghese

    Citation: Molecular Autism 2020 11:89

    Content type: Research

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  16. Recent progress in genomics has contributed to the identification of a large number of autism spectrum disorder (ASD) risk genes, many of which encode synaptic proteins. Our understanding of ASDs has advanced ...

    Authors: Kyung Ah Han, Taek Han Yoon, Jungsu Shin, Ji Won Um and Jaewon Ko

    Citation: Molecular Autism 2020 11:87

    Content type: Short report

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  17. Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influenc...

    Authors: Ting Mei, Alberto Llera, Dorothea L. Floris, Natalie J. Forde, Julian Tillmann, Sarah Durston, Carolin Moessnang, Tobias Banaschewski, Rosemary J. Holt, Simon Baron-Cohen, Annika Rausch, Eva Loth, Flavio Dell’Acqua, Tony Charman, Declan G. M. Murphy, Christine Ecker…

    Citation: Molecular Autism 2020 11:86

    Content type: Research

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  18. Neurodevelopmental disorders such as autism spectrum disorder (ASD) may be caused by alterations in genes encoding proteins that are involved in synapse formation and function. This includes scaffold proteins ...

    Authors: Fatemeh Hassani Nia, Daniel Woike, Victoria Martens, Malte Klüssendorf, Hans-Hinrich Hönck, Sönke Harder and Hans-Jürgen Kreienkamp

    Citation: Molecular Autism 2020 11:85

    Content type: Research

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  19. There is a growing recognition of sex and gender influences in autism. Increasingly, studies include comparisons between sexes or genders, but few have focused on clarifying the characteristics of autistic gir...

    Authors: Caroline Kassee, Stephanie Babinski, Ami Tint, Yona Lunsky, Hilary K. Brown, Stephanie H. Ameis, Peter Szatmari, Meng-Chuan Lai and Gillian Einstein

    Citation: Molecular Autism 2020 11:84

    Content type: Review

    Published on:

  20. Face individual identity recognition skill is heritable and independent of intellectual ability. Difficulties in face individual identity recognition are present in autistic individuals and their family member...

    Authors: Ilaria Minio-Paluello, Giuseppina Porciello, Alvaro Pascual-Leone and Simon Baron-Cohen

    Citation: Molecular Autism 2020 11:81

    Content type: Research

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  21. The human orbitofrontal cortex (OFC) is involved in assessing the emotional significance of events and stimuli, emotion-based learning, allocation of attentional resources, and social cognition. Little is know...

    Authors: Xuefeng Liu, Julied Bautista, Edward Liu and Basilis Zikopoulos

    Citation: Molecular Autism 2020 11:83

    Content type: Research

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  22. Autism spectrum disorder (ASD) is characterized by high population-level heritability and a three-to-one male-to-female ratio that occurs independent of sex linkage. Prior research in a mixed-sex pediatric sam...

    Authors: Adam T. Eggebrecht, Ally Dworetsky, Zoë Hawks, Rebecca Coalson, Babatunde Adeyemo, Savannah Davis, Daniel Gray, Alana McMichael, Steven E. Petersen, John N. Constantino and John R. Pruett Jr

    Citation: Molecular Autism 2020 11:82

    Content type: Research

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  23. Tuberous sclerosis complex (TSC) is a rare genetic multisystemic disorder resulting from autosomal dominant mutations in the TSC1 or TSC2 genes. It is characterised by hyperactivation of the mechanistic target of...

    Authors: Mouhamed Alsaqati, Vivi M. Heine and Adrian J. Harwood

    Citation: Molecular Autism 2020 11:80

    Content type: Research

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  24. Diminished visual monitoring of faces and activities of others is an early feature of autism spectrum disorder (ASD). It is uncertain whether deficits in activity monitoring, identified using a homogeneous set...

    Authors: Dzmitry A. Kaliukhovich, Nikolay V. Manyakov, Abigail Bangerter, Seth Ness, Andrew Skalkin, Matthew S. Goodwin, Geraldine Dawson, Robert L. Hendren, Bennett Leventhal, Caitlin M. Hudac, Jessica Bradshaw, Frederick Shic and Gahan Pandina

    Citation: Molecular Autism 2020 11:79

    Content type: Research

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  25. Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have high rates of co-occurrence and share atypical behavioral characteristics, including sensory symptoms. The present diffus...

    Authors: Haruhisa Ohta, Yuta Y. Aoki, Takashi Itahashi, Chieko Kanai, Junya Fujino, Motoaki Nakamura, Nobumasa Kato and Ryu-ichiro Hashimoto

    Citation: Molecular Autism 2020 11:77

    Content type: Research

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  26. Mutations in TSC2 are the most common cause of tuberous sclerosis (TSC), a disorder with a high incidence of autism and intellectual disability. TSC2 regulates mRNA translation required for group 1 metabotropic g...

    Authors: Annie Hien, Gemma Molinaro, Botao Liu, Kimberly M. Huber and Joel D. Richter

    Citation: Molecular Autism 2020 11:78

    Content type: Research

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  27. Whole-exome sequencing studies have been useful for identifying genes that, when mutated, affect risk for autism spectrum disorder (ASD). Nonetheless, the association signal primarily arises from de novo prote...

    Authors: Siwei Chen, Jiebiao Wang, Ercument Cicek, Kathryn Roeder, Haiyuan Yu and Bernie Devlin

    Citation: Molecular Autism 2020 11:76

    Content type: Research

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  28. Both de novo variants and recessive inherited variants were associated with autism spectrum disorder (ASD). This study aimed to use exome data to prioritize recessive inherited genes (RIGs) with biallelically ...

    Authors: Lin Wang, Yi Zhang, Kuokuo Li, Zheng Wang, Xiaomeng Wang, Bin Li, Guihu Zhao, Zhenghuan Fang, Zhengbao Ling, Tengfei Luo, Lu Xia, Yanping Li, Hui Guo, Zhengmao Hu, Jinchen Li, Zhongsheng Sun…

    Citation: Molecular Autism 2020 11:75

    Content type: Research

    Published on:

  29. Chromodomain helicase DNA-binding protein 8 (Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 haploinsufficiency impairs gene expression in the brain and impacts behavior...

    Authors: Jessica A. Jiménez, Travis S. Ptacek, Alex H. Tuttle, Ralf S. Schmid, Sheryl S. Moy, Jeremy M. Simon and Mark J. Zylka

    Citation: Molecular Autism 2020 11:74

    Content type: Research

    Published on:

    The Correction to this article has been published in Molecular Autism 2021 12:33

  31. Impaired imitation has been found to be an important factor contributing to social communication deficits in individuals with autism spectrum disorder (ASD). It has been hypothesized that the neural correlate ...

    Authors: Melody M. Y. Chan and Yvonne M. Y. Han

    Citation: Molecular Autism 2020 11:72

    Content type: Research

    Published on:

  32. Recent theories have linked autism to challenges in prediction learning and social cognition. It is unknown, however, how autism affects learning about threats from others “demonstrators” through observation, ...

    Authors: Lisa Espinosa, Johan Lundin Kleberg, Björn Hofvander, Steve Berggren, Sven Bölte and Andreas Olsson

    Citation: Molecular Autism 2020 11:71

    Content type: Research

    Published on:

  33. Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by the loss of functional ubiquitin protein ligase E3A (UBE3A). In neurons, UBE3A expression is tightly regulated by a mechanism of imprintin...

    Authors: Monica Sonzogni, Peipei Zhai, Edwin J. Mientjes, Geeske M. van Woerden and Ype Elgersma

    Citation: Molecular Autism 2020 11:70

    Content type: Research

    Published on:

  34. The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds of genes, converging at the functional level on selective b...

    Authors: Cristina Cheroni, Nicolò Caporale and Giuseppe Testa

    Citation: Molecular Autism 2020 11:69

    Content type: Review

    Published on:

  35. Several genetic alterations, including point mutations and copy number variations in NLGN genes, have been associated with psychiatric disorders, such as autism spectrum disorder (ASD) and X-linked mental retarda...

    Authors: Takafumi Yumoto, Misaki Kimura, Ryota Nagatomo, Tsukika Sato, Shun Utsunomiya, Natsue Aoki, Motoji Kitaura, Koji Takahashi, Hiroshi Takemoto, Hirotaka Watanabe, Hideyuki Okano, Fumiaki Yoshida, Yosuke Nao and Taisuke Tomita

    Citation: Molecular Autism 2020 11:68

    Content type: Research

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  36. Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a multidi...

    Authors: J. Tillmann, M. Uljarevic, D. Crawley, G. Dumas, E. Loth, D. Murphy, J. Buitelaar and T. Charman

    Citation: Molecular Autism 2020 11:67

    Content type: Research

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  37. Placebo response in autism spectrum disorder (ASD) might dilute drug-placebo differences and hinder drug development. Therefore, this meta-analysis investigated placebo response in core symptoms.

    Authors: Spyridon Siafis, Oğulcan Çıray, Johannes Schneider-Thoma, Irene Bighelli, Marc Krause, Alessandro Rodolico, Anna Ceraso, Giacomo Deste, Maximilian Huhn, David Fraguas, Dimitris Mavridis, Tony Charman, Declan G. Murphy, Mara Parellada, Celso Arango and Stefan Leucht

    Citation: Molecular Autism 2020 11:66

    Content type: Research

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  38. Partial or an entire deletion of SHANK3 are considered as major drivers in the Phelan–McDermid syndrome, in which 75% of patients are diagnosed with autism spectrum disorder (ASD). During the recent years, there ...

    Authors: N. Perets, O. Oron, S. Herman, E. Elliott and D. Offen

    Citation: Molecular Autism 2020 11:65

    Content type: Research

    Published on:

  40. Recognising the signs of autism spectrum disorder (ASD) can be a challenge for frontline professionals. The use of brief parent-completed questionnaires for recording the signs of ASD in school-aged children m...

    Authors: Catherine R. G. Jones, Sarah L. Barrett, Ieva Bite, Maria Legzdina, Kristina Arina, Andrea Higgins, Kyla Honey, Sarah J. Carrington, Dale Hay, Johanna Condon and Susan R. Leekam

    Citation: Molecular Autism 2020 11:64

    Content type: Research

    Published on:

  42. The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients. ASD prevalence is higher in...

    Authors: Simona Scheggi, Francesca Guzzi, Giulia Braccagni, Maria Graziella De Montis, Marco Parenti and Carla Gambarana

    Citation: Molecular Autism 2020 11:62

    Content type: Research

    Published on:

  43. The new coronavirus disease (COVID-19) pandemic is changing how society operates. Environmental changes, disrupted routines, and reduced access to services and social networks will have a unique impact on auti...

    Authors: Stephanie H. Ameis, Meng-Chuan Lai, Benoit H. Mulsant and Peter Szatmari

    Citation: Molecular Autism 2020 11:61

    Content type: Commentary

    Published on:

  47. There is growing recognition that autistic females present with more diverse gender and sexual identities than their non-autistic counterparts. Likewise, autistic females are also at an increased risk of adver...

    Authors: Laura A. Pecora, Grace I. Hancock, Merrilyn Hooley, David H. Demmer, Tony Attwood, Gary B. Mesibov and Mark A. Stokes

    Citation: Molecular Autism 2020 11:57

    Content type: Research

    Published on:

  48. Auditory steady state responses (ASSRs) are elicited by clicktrains or amplitude-modulated tones, which entrain auditory cortex at their specific modulation rate. Previous research has reported reductions in A...

    Authors: R. A. Seymour, G. Rippon, G. Gooding-Williams, P. F. Sowman and K. Kessler

    Citation: Molecular Autism 2020 11:56

    Content type: Research

    Published on:

  50. Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia. The potential mechanisms conferring this risk are poorly understood. Here, we show tha...

    Authors: Axel Krug, Markus Wöhr, Dominik Seffer, Henrike Rippberger, A. Özge Sungur, Bruno Dietsche, Frederike Stein, Sugirthan Sivalingam, Andreas J. Forstner, Stephanie H. Witt, Helene Dukal, Fabian Streit, Anna Maaser, Stefanie Heilmann-Heimbach, Till F. M. Andlauer, Stefan Herms…

    Citation: Molecular Autism 2020 11:54

    Content type: Research

    Published on:

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Molecular Autism

ISSN: 2040-2392