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  1. One of the most consistent findings in autism spectrum disorder (ASD) research is a higher rate of ASD diagnosis in males than females. Despite this, remarkably little research has focused on the reasons for t...

    Authors: Alycia K Halladay, Somer Bishop, John N Constantino, Amy M Daniels, Katheen Koenig, Kate Palmer, Daniel Messinger, Kevin Pelphrey, Stephan J Sanders, Alison Tepper Singer, Julie Lounds Taylor and Peter Szatmari
    Citation: Molecular Autism 2015 6:36
  2. The prevalence of autism spectrum disorders (ASDs) is higher in men than in women. The extreme male brain theory proposes that excessive prenatal testosterone activity could be a risk factor for ASDs. However,...

    Authors: Yasuhiro Masuya, Yuko Okamoto, Keisuke Inohara, Yukiko Matsumura, Toru Fujioka, Yuji Wada and Hirotaka Kosaka
    Citation: Molecular Autism 2015 6:34
  3. Several observations support the hypothesis that differences in synaptic and regional cerebral plasticity between the sexes account for the high ratio of males to females in autism. First, males are more susce...

    Authors: Laurent Mottron, Pauline Duret, Sophia Mueller, Robert D Moore, Baudouin Forgeot d’Arc, Sebastien Jacquemont and Lan Xiong
    Citation: Molecular Autism 2015 6:33
  4. The increased male prevalence of autism spectrum disorder (ASD) may be mirrored by the early emergence of sex differences in ASD symptoms and cognitive functioning. The female protective effect hypothesis posi...

    Authors: Daniel S. Messinger, Gregory S. Young, Sara Jane Webb, Sally Ozonoff, Susan E. Bryson, Alice Carter, Leslie Carver, Tony Charman, Katarzyna Chawarska, Suzanne Curtin, Karen Dobkins, Irva Hertz-Picciotto, Ted Hutman, Jana M. Iverson, Rebecca Landa, Charles A. Nelson…
    Citation: Molecular Autism 2015 6:32
  5. Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-...

    Authors: Takashi Itahashi, Takashi Yamada, Hiromi Watanabe, Motoaki Nakamura, Haruhisa Ohta, Chieko Kanai, Akira Iwanami, Nobumasa Kato and Ryu-ichiro Hashimoto
    Citation: Molecular Autism 2015 6:30
  6. Neuroanatomical differences between individuals with and without autism spectrum disorder (ASD) were inconsistent in the literature. Such heterogeneity may substantially originate from age-differential effects.

    Authors: Hsiang-Yuan Lin, Hsing-Chang Ni, Meng-Chuan Lai, Wen-Yih Isaac Tseng and Susan Shur-Fen Gau
    Citation: Molecular Autism 2015 6:29
  7. The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain...

    Authors: Michelle J Chandley, Jessica D Crawford, Attila Szebeni, Katalin Szebeni and Gregory A Ordway
    Citation: Molecular Autism 2015 6:28

    The Erratum to this article has been published in Molecular Autism 2015 6:38

  8. Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on average, protected by sex-differential mechanisms. Under this model, autis...

    Authors: Donna M Werling and Daniel H Geschwind
    Citation: Molecular Autism 2015 6:27
  9. Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion...

    Authors: Christine Wu Nordahl, Ana-Maria Iosif, Gregory S Young, Lee Michael Perry, Robert Dougherty, Aaron Lee, Deana Li, Michael H Buonocore, Tony Simon, Sally Rogers, Brian Wandell and David G Amaral
    Citation: Molecular Autism 2015 6:26

    The Erratum to this article has been published in Molecular Autism 2015 6:39

  10. A 4:1 male to female sex bias has consistently been observed in autism spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective effect (FPE) may account for part of this bias; h...

    Authors: Jake Gockley, A Jeremy Willsey, Shan Dong, Joseph D Dougherty, John N Constantino and Stephan J Sanders
    Citation: Molecular Autism 2015 6:25
  11. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors and r...

    Authors: Valerie W Hu, Tewarit Sarachana, Rachel M Sherrard and Kristen M Kocher
    Citation: Molecular Autism 2015 6:7
  12. SHANK proteins are crucial for the formation and plasticity of excitatory synapses. Although mutations in all three SHANK genes are associated with autism spectrum disorder (ASD), SHANK3 appears to be the major A...

    Authors: Daniela M Cochoy, Alexander Kolevzon, Yuji Kajiwara, Michael Schoen, Maria Pascual-Lucas, Stacey Lurie, Joseph D Buxbaum, Tobias M Boeckers and Michael J Schmeisser
    Citation: Molecular Autism 2015 6:23
  13. Difficulties in recognizing emotions and mental states are central characteristics of autism spectrum conditions (ASC). However, emotion recognition (ER) studies have focused mostly on recognition of the six ‘...

    Authors: Ofer Golan, Yana Sinai-Gavrilov and Simon Baron-Cohen
    Citation: Molecular Autism 2015 6:22
  14. Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with high heritability. Recent findings support a highly heterogeneous and complex genetic etiology including rare de novo and inherited...

    Authors: Marta Codina-Solà, Benjamín Rodríguez-Santiago, Aïda Homs, Javier Santoyo, Maria Rigau, Gemma Aznar-Laín, Miguel del Campo, Blanca Gener, Elisabeth Gabau, María Pilar Botella, Armand Gutiérrez-Arumí, Guillermo Antiñolo, Luis Alberto Pérez-Jurado and Ivon Cuscó
    Citation: Molecular Autism 2015 6:21
  15. Apparently balanced chromosomal rearrangements can be associated with an abnormal phenotype, including intellectual disability and autism spectrum disorder (ASD). Genome-wide microarrays reveal cryptic genomic...

    Authors: Anne-Claude Tabet, Alain Verloes, Marion Pilorge, Elsa Delaby, Richard Delorme, Gudrun Nygren, Françoise Devillard, Marion Gérard, Sandrine Passemard, Delphine Héron, Jean-Pierre Siffroi, Aurelia Jacquette, Andrée Delahaye, Laurence Perrin, Céline Dupont, Azzedine Aboura…
    Citation: Molecular Autism 2015 6:19
  16. Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting more than 1% of children. It is characterized by social communication deficits and repetitive behaviors/restricted interests. In the ab...

    Authors: Deepali Mankad, Annie Dupuis, Sharon Smile, Wendy Roberts, Jessica Brian, Toni Lui, Lisa Genore, Dina Zaghloul, Alana Iaboni, Peggy Margaret A Marcon and Evdokia Anagnostou
    Citation: Molecular Autism 2015 6:18
  17. Autism spectrum disorder (ASD) has a complex genetic etiology. Some symptoms and mutated genes, including neuroligin (NLGN), neurexin (NRXN), and SH3 and multiple ankyrin repeat domains protein (SHANK), are share...

    Authors: Eriko Fujita-Jimbo, Yuko Tanabe, Zhiling Yu, Karin Kojima, Masato Mori, Hong Li, Sadahiko Iwamoto, Takanori Yamagata, Mariko Y Momoi and Takashi Momoi
    Citation: Molecular Autism 2015 6:17
  18. The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals w...

    Authors: Brittany G Travers, Do P M Tromp, Nagesh Adluru, Nicholas Lange, Dan Destiche, Chad Ennis, Jared A Nielsen, Alyson L Froehlich, Molly B D Prigge, P Thomas Fletcher, Jeffrey S Anderson, Brandon A Zielinski, Erin D Bigler, Janet E Lainhart and Andrew L Alexander
    Citation: Molecular Autism 2015 6:15
  19. The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN).

    Authors: Søren Nielsen, Henrik Anckarsäter, Carina Gillberg, Christopher Gillberg, Maria Råstam and Elisabet Wentz
    Citation: Molecular Autism 2015 6:14
  20. An important minority of school-aged autistic children, often characterized as ‘nonverbal’ or ‘minimally verbal,’ displays little or no spoken language. These children are at risk of being judged ‘low-function...

    Authors: Valérie Courchesne, Andrée-Anne S Meilleur, Marie-Pier Poulin-Lord, Michelle Dawson and Isabelle Soulières
    Citation: Molecular Autism 2015 6:12
  21. Preschoolers with autism spectrum disorder (ASD) exhibit difficulties in handling social stress and utilizing efficient emotion regulation (ER) strategies to manage high arousal. While researchers called to as...

    Authors: Sharon Ostfeld-Etzion, Ofer Golan, Yael Hirschler-Guttenberg, Orna Zagoory-Sharon and Ruth Feldman
    Citation: Molecular Autism 2015 6:11
  22. Our laboratory recently characterized a novel autism spectrum disorder (ASD)-associated de novo missense mutation in the human dopamine transporter (hDAT) gene SLC6A3 (hDAT T356M). This hDAT variant exhibits dysf...

    Authors: Peter J Hamilton, Aparna Shekar, Andrea N Belovich, Nicole Bibus Christianson, Nicholas G Campbell, James S Sutcliffe, Aurelio Galli, Heinrich JG Matthies and Kevin Erreger
    Citation: Molecular Autism 2015 6:8
  23. The aim of this study was to investigate potential differences in neural structure in individuals with Asperger syndrome (AS), high-functioning individuals with autism spectrum disorder (ASD). The main symptom...

    Authors: Ulrika Roine, Juha Salmi, Timo Roine, Taina Nieminen-von Wendt, Sami Leppämäki, Pertti Rintahaka, Pekka Tani, Alexander Leemans and Mikko Sams
    Citation: Molecular Autism 2015 6:4
  24. Insufficient vitamin D activity has attracted increasing interest as a possible underlying risk factor in disorders of the central nervous system, including autism.

    Authors: Elisabeth Fernell, Susanne Bejerot, Joakim Westerlund, Carmela Miniscalco, Henry Simila, Darryl Eyles, Christopher Gillberg and Mats B Humble
    Citation: Molecular Autism 2015 6:3
  25. The Autism-Spectrum Quotient (AQ) is a self-report measure of autistic traits. It is frequently cited in diverse fields and has been administered to adults of at least average intelligence with autism and to n...

    Authors: Emily Ruzich, Carrie Allison, Paula Smith, Peter Watson, Bonnie Auyeung, Howard Ring and Simon Baron-Cohen
    Citation: Molecular Autism 2015 6:2

    The Erratum to this article has been published in Molecular Autism 2015 6:45

  26. This study was designed to test a new approach to drug treatment of autism spectrum disorders (ASDs) in the Fragile X (Fmr1) knockout mouse model.

    Authors: Jane C Naviaux, Lin Wang, Kefeng Li, A Taylor Bright, William A Alaynick, Kenneth R Williams, Susan B Powell and Robert K Naviaux
    Citation: Molecular Autism 2015 6:1
  27. There is converging preclinical and clinical evidence to suggest that the extracellular signal-regulated kinase (ERK) signaling pathway may be dysregulated in autism spectrum disorders.

    Authors: Alireza Faridar, Dorothy Jones-Davis, Eric Rider, Jiang Li, Ilan Gobius, Laura Morcom, Linda J Richards, Saunak Sen and Elliott H Sherr
    Citation: Molecular Autism 2014 5:57
  28. There may be a link between anorexia nervosa and autism spectrum disorders. The aims of this study were to examine whether adolescents with anorexia nervosa have autism spectrum and/or obsessive-compulsive tra...

    Authors: Charlotte Rhind, Elena Bonfioli, Rebecca Hibbs, Elizabeth Goddard, Pamela Macdonald, Simon Gowers, Ulrike Schmidt, Kate Tchanturia, Nadia Micali and Janet Treasure
    Citation: Molecular Autism 2014 5:56
  29. Autistic-like traits (ALTs) are continuously distributed in the general population, with the autism spectrum disorder (ASD) at the upper extreme end. A genetic overlap has been shown between ALTs and ASD, indi...

    Authors: Lina Jonsson, Anna Zettergren, Erik Pettersson, Daniel Hovey, Henrik Anckarsäter, Lars Westberg, Paul Lichtenstein, Sebastian Lundström and Jonas Melke
    Citation: Molecular Autism 2014 5:55
  30. Autism spectrum disorder (ASD) is now understood to have multiple genetic risk genes and one example is SHANK3. SHANK3 deletions and mutations disrupt synaptic function and result in Phelan-McDermid syndrome (PMS...

    Authors: Alexander Kolevzon, Lauren Bush, A Ting Wang, Danielle Halpern, Yitzchak Frank, David Grodberg, Robert Rapaport, Teresa Tavassoli, William Chaplin, Latha Soorya and Joseph D Buxbaum
    Citation: Molecular Autism 2014 5:54

    The Erratum to this article has been published in Molecular Autism 2015 6:31

  31. People with autism spectrum conditions (ASC) report heightened olfaction. Previous sensory experiments in people with ASC have reported hypersensitivity across visual, tactile, and auditory domains, but not ol...

    Authors: Chris Ashwin, Emma Chapman, Jessica Howells, Danielle Rhydderch, Ian Walker and Simon Baron-Cohen
    Citation: Molecular Autism 2014 5:53
  32. Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and interaction, and restrictive and repetitive patterns of behavior, interests or activities. This study aimed to...

    Authors: Wei-Zhen Zhou, Adam Yongxin Ye, Zhong-Kai Sun, Hope Huiping Tian, Tad Zhengzhang Pu, Yu-Yu Wu, Dan-Dan Wang, Ming-Zhen Zhao, Shu-Juan Lu, Chang-Hong Yang and Liping Wei
    Citation: Molecular Autism 2014 5:52
  33. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social cognition. The biological basis of deficits in social cognition in ASD, and their difficulty in processing...

    Authors: Rachel C Leung, Annette X Ye, Simeon M Wong, Margot J Taylor and Sam M Doesburg
    Citation: Molecular Autism 2014 5:51
  34. The ability to interpret agents’ intent from their actions is a vital skill in successful social interaction. However, individuals with autism spectrum disorders (ASD) have been found to have difficulty in att...

    Authors: Lauren E Libero, Jose O Maximo, Hrishikesh D Deshpande, Laura G Klinger, Mark R Klinger and Rajesh K Kana
    Citation: Molecular Autism 2014 5:50
  35. Histone H3 methylation at lysine 9 (H3K9) is a conserved epigenetic signal, mediating heterochromatin formation by trimethylation, and transcriptional silencing by dimethylation. Defective GLP (Ehmt1) and G9a (Eh...

    Authors: Shabeesh Balan, Yoshimi Iwayama, Motoko Maekawa, Tomoko Toyota, Tetsuo Ohnishi, Manabu Toyoshima, Chie Shimamoto, Kayoko Esaki, Kazuo Yamada, Yasuhide Iwata, Katsuaki Suzuki, Masayuki Ide, Motonori Ota, Satoshi Fukuchi, Masatsugu Tsujii, Norio Mori…
    Citation: Molecular Autism 2014 5:49
  36. Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by impairments in communication and social interaction, alongside unusually repetitive behaviors and narrow interests...

    Authors: Agnese Di Napoli, Varun Warrier, Simon Baron-Cohen and Bhismadev Chakrabarti
    Citation: Molecular Autism 2014 5:48
  37. Individuals with autism spectrum disorder (ASD) show atypical scan paths during social interaction and when viewing faces, and recent evidence suggests that they also show abnormal saccadic eye movement dynami...

    Authors: Lauren M Schmitt, Edwin H Cook, John A Sweeney and Matthew W Mosconi
    Citation: Molecular Autism 2014 5:47
  38. Autism spectrum disorders (ASD) are much more common in males than in females. Molecular alterations within the estrogen receptor (ER) signaling pathway may contribute to the sex difference in ASD, but the ext...

    Authors: Amanda Crider, Roshni Thakkar, Anthony O Ahmed and Anilkumar Pillai
    Citation: Molecular Autism 2014 5:46
  39. Although the neurobiological basis of autism spectrum disorder (ASD) is not fully understood, recent studies have indicated the potential role of GABAA receptors in the pathophysiology of ASD. GABAA receptors pla...

    Authors: Amanda Crider, Chirayu D Pandya, Diya Peter, Anthony O Ahmed and Anilkumar Pillai
    Citation: Molecular Autism 2014 5:45
  40. Duplications of the chromosome 15q11-q13.1 region are associated with an estimated 1 to 3% of all autism cases, making this copy number variation (CNV) one of the most frequent chromosome abnormalities associa...

    Authors: Noelle D Germain, Pin-Fang Chen, Alex M Plocik, Heather Glatt-Deeley, Judith Brown, James J Fink, Kaitlyn A Bolduc, Tiwanna M Robinson, Eric S Levine, Lawrence T Reiter, Brenton R Graveley, Marc Lalande and Stormy J Chamberlain
    Citation: Molecular Autism 2014 5:44

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