Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, Charman T. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet. 2006;368:210–5.
Article
PubMed
Google Scholar
Brugha TS, McManus S, Bankart J, Scott F, Purdon S, Smith J, Bebbington P, Jenkins R, Meltzer H. Epidemiology of autism spectrum disorders in adults in the community in England. Arch Gen Psychiatry. 2011;68:459–65.
Article
PubMed
Google Scholar
Christensen DL. Prevalence and characteristics of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2012. MMWR Surveill Summ. 2016;65:1–23.
Article
PubMed
Google Scholar
Gokoolparsadh A, Sutton G, A. C, Green N, Pardy C, Voineagu I. Searching for convergent pathways in autism spectrum disorders: insights from human brain transcriptome studies. Cell Mol Life Sci. 2016;73:4517–30.
Article
CAS
PubMed
Google Scholar
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: Author; 2013.
Book
Google Scholar
Lai M-C, Lombardo MV, Chakrabarti B, Baron-Cohen S. Subgrouping the autism “spectrum”: reflections on DSM-5. PLoS Biol. 2013;11:e1001544.
Article
CAS
PubMed
PubMed Central
Google Scholar
Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G. Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry. 2008;47:921–9.
Article
PubMed
Google Scholar
Lai M-C, Lombardo MV, Baron-Cohen S. Autism. Lancet. 2014;383:896–910.
Article
PubMed
Google Scholar
Charman T. Variability in neuro-developmental disorders evidence from autism spectrum disorders. In: Van Herwegen J, Riby DM, editors. Neurodevelopmental Disorders : Research Challenges and Solutions. Hove: Psychology Press; 2015.
Google Scholar
Lord C, Bishop S, Anderson D. Developmental trajectories as autism phenotypes. Am J Med Genet C: Semin Med Genet. 2015;169:198–208.
Article
Google Scholar
LLombardo MV, Lai M-C, Auyeung B, Holt RJ, Allison C, Smith P, Chakrabarti B, Ruigrok AN, Suckling J, Bullmore ET, MRC AIMS Consortium, Ecker C, Craig MC, Murphy DGM, Happé F, Baron-Cohen S. Unsupervised data-driven stratification of mentalizing heterogeneity in autism. Scientific Reports. 2016;6:35333.
Google Scholar
Gaugler T, Klei L, Sanders SJ, Bodea CA, Goldberg AP, Lee AB, Mahajan M, Manaa D, Pawitan Y, Reichert J. Most genetic risk for autism resides with common variation. Nat Genet. 2014;46:881–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Geschwind DH, State MW. Gene hunting in autism spectrum disorder: on the path to precision medicine. Lancet Neurol. 2015;14:1109–20.
Article
PubMed
PubMed Central
Google Scholar
Bourgeron T. From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci. 2015;16:551–63.
Article
CAS
PubMed
Google Scholar
Mandy W, Lai MC. Annual research review: the role of the environment in the developmental psychopathology of autism spectrum condition. J Child Psychol Psychiatry. 2016;57:271–92.
Article
PubMed
Google Scholar
Jeste SS, Geschwind DH. Disentangling the heterogeneity of autism spectrum disorder through genetic findings. Nat Rev Neurol. 2014;10:74–81.
Article
PubMed
PubMed Central
Google Scholar
Zhao Y, Castellanos FX. Annual research review: discovery science strategies in studies of the pathophysiology of child and adolescent psychiatric disorders‐promises and limitations. J Child Psychol Psychiatry. 2016;57:421–39.
Article
PubMed
PubMed Central
Google Scholar
Lai M-C, Lombardo MV, Auyeung B, Chakrabarti B, Baron-Cohen S. Sex/gender differences and autism: setting the scene for future research. J Am Acad Child Adolesc Psychiatry. 2015;54:11–24.
Article
PubMed
PubMed Central
Google Scholar
Van Wijngaarden-Cremers PJ, van Eeten E, Groen WB, Van Deurzen PA, Oosterling IJ, Van der Gaag RJ. Gender and age differences in the core triad of impairments in autism spectrum disorders: a systematic review and meta-analysis. J Autism Dev Disord. 2014;44:627–35.
Article
PubMed
Google Scholar
Dworzynski K, Ronald A, Bolton P, Happé F. How different are girls and boys above and below the diagnostic threshold for autism spectrum disorders? J Am Acad Child Adolesc Psychiatry. 2012;51:788–97.
Article
PubMed
Google Scholar
Wilson CE, Murphy CM, McAlonan G, Robertson DM, Spain D, Hayward H, Woodhouse E, Deeley PQ, Gillan N, Ohlsen JC. Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? Autism. 2016;20:808–19.
Article
PubMed
PubMed Central
Google Scholar
Frazier TW, Georgiades S, Bishop SL, Hardan AY. Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection. J Am Acad Child Adolesc Psychiatry. 2014;53:329–40. e323.
Article
PubMed
Google Scholar
Szatmari P, Liu XQ, Goldberg J, Zwaigenbaum L, Paterson AD, Woodbury‐Smith M, Georgiades S, Duku E, Thompson A. Sex differences in repetitive stereotyped behaviors in autism: implications for genetic liability. Am J Med Genet B Neuropsychiatr Genet. 2012;159:5–12.
Article
Google Scholar
Hiller RM, Young RL, Weber N. Sex differences in autism spectrum disorder based on DSM-5 criteria: evidence from clinician and teacher reporting. J Abnorm Child Psychol. 2014;42:1381–93.
Article
PubMed
Google Scholar
Mandy W, Chilvers R, Chowdhury U, Salter G, Seigal A, Skuse D. Sex differences in autism spectrum disorder: evidence from a large sample of children and adolescents. J Autism Dev Disord. 2012;42:1304–13.
Article
PubMed
Google Scholar
May T, Cornish K, Rinehart N. Does gender matter? A one year follow-up of autistic, attention and anxiety symptoms in high-functioning children with autism spectrum disorder. J Autism Dev Disord. 2014;44:1077–86.
Article
PubMed
Google Scholar
Charman T, Taylor E, Drew A, Cockerill H, Brown J-A, Baird G. Outcome at 7 years of children diagnosed with autism at age 2: predictive validity of assessments conducted at 2 and 3 years of age and pattern of symptom change over time. J Child Psychol Psychiatry. 2005;46:500–13.
Article
PubMed
Google Scholar
Fountain C, Winter AS, Bearman PS. Six developmental trajectories characterize children with autism. Pediatrics. 2012;129:e1112–20.
Article
PubMed
PubMed Central
Google Scholar
Gotham K, Pickles A, Lord C. Trajectories of autism severity in children using standardized ADOS scores. Pediatrics. 2012;130:e1278–84.
Article
PubMed
PubMed Central
Google Scholar
Lombardo MV, Pierce K, Eyler LT, Barnes CC, Ahrens-Barbeau C, Solso S, Campbell K, Courchesne E. Different functional neural substrates for good and poor language outcome in autism. Neuron. 2015;86:567–77.
Article
CAS
PubMed
PubMed Central
Google Scholar
Szatmari P, Georgiades S, Duku E, Bennett TA, Bryson S, Fombonne E, Mirenda P, Roberts W, Smith IM, Vaillancourt T. Developmental trajectories of symptom severity and adaptive functioning in an inception cohort of preschool children with autism spectrum disorder. JAMA Psychiatry. 2015;72:276–83.
Article
PubMed
Google Scholar
Bal VH, Kim S-H, Cheong D, Lord C. Daily living skills in individuals with autism spectrum disorder from 2 to 21 years of age. Autism. 2015;19:774–84.
Article
PubMed
Google Scholar
Szatmari P, Bryson S, Duku E, Vaccarella L, Zwaigenbaum L, Bennett T, Boyle MH. Similar developmental trajectories in autism and Asperger syndrome: from early childhood to adolescence. J Child Psychol Psychiatry. 2009;50:1459–67.
Article
PubMed
Google Scholar
Billstedt E, Carina Gillberg I, Gillberg C. Autism in adults: symptom patterns and early childhood predictors. Use of the DISCO in a community sample followed from childhood. J Child Psychol Psychiatry. 2007;48:1102–10.
Article
PubMed
Google Scholar
Howlin P, Moss P, Savage S, Rutter M. Social outcomes in mid-to later adulthood among individuals diagnosed with autism and average nonverbal IQ as children. J Am Acad Child Adolesc Psychiatry. 2013;52:572–81. e571.
Article
PubMed
Google Scholar
Shattuck PT, Seltzer MM, Greenberg JS, Orsmond GI, Bolt D, Kring S, Lounds J, Lord C. Change in autism symptoms and maladaptive behaviors in adolescents and adults with an autism spectrum disorder. J Autism Dev Disord. 2007;37:1735–47.
Article
PubMed
Google Scholar
Verheij C, Louwerse A, van der Ende J, Eussen M, Van Gool A, Verheij F, Verhulst F, Greaves-Lord K. The stability of comorbid psychiatric disorders: a 7 year follow up of children with pervasive developmental disorder-not otherwise specified. J Autism Dev Disord. 2015;45:3939–48.
Article
CAS
PubMed
PubMed Central
Google Scholar
Simonoff E, Jones CR, Baird G, Pickles A, Happé F, Charman T. The persistence and stability of psychiatric problems in adolescents with autism spectrum disorders. J Child Psychol Psychiatry. 2013;54:186–94.
Article
PubMed
Google Scholar
Taylor JL, Seltzer MM. Changes in the autism behavioral phenotype during the transition to adulthood. J Autism Dev Disord. 2010;40:1431–46.
Article
PubMed
PubMed Central
Google Scholar
Lever AG, Geurts HM. Psychiatric co-occurring symptoms and disorders in young, middle-aged, and older adults with autism spectrum disorder. J Autism Dev Disord. 2016;46:1916–30.
Article
PubMed
PubMed Central
Google Scholar
Bishop SL, Richler J, Lord C. association between restricted and repetitive behaviors and nonverbal IQ in children with autism spectrum disorders. Child Neuropsychol. 2006;12:247–67.
Article
PubMed
Google Scholar
Mayes SD, Calhoun SL, Murray MJ, Zahid J. Variables associated with anxiety and depression in children with autism. J Dev Phys Disabil. 2011;23:325–37.
Article
Google Scholar
Ford T, Goodman R, Meltzer H. The relative importance of child, family, school and neighbourhood correlates of childhood psychiatric disorder. Soc Psychiatry Psychiatr Epidemiol. 2004;39:487–96.
Article
PubMed
Google Scholar
Hinshaw SP. Externalizing behavior problems and academic underachievement in childhood and adolescence: causal relationships and underlying mechanisms. Psychol Bull. 1992;111:127.
Article
CAS
PubMed
Google Scholar
van Steensel FJA, Bögels SM, Perrin S. Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis. Clin Child Fam Psychol Rev. 2011;14:302.
Article
PubMed
PubMed Central
Google Scholar
Loth E, Charman T, Mason L, Jones EJH, Wooldridge C, Amad J, Auyeung B, Brogna C, Ambrosino S, Banaschewski T, et al.. The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders. Molecular Autism (submitted).
Murphy D, Spooren W. EU-AIMS: a boost to autism research. Nat Rev Drug Discov. 2012;11:815.
Article
CAS
PubMed
Google Scholar
Loth E, Spooren W, Murphy DG. New treatment targets for autism spectrum disorders: EU-AIMS. Lancet Psychiatry. 2014;1:413–5.
Article
PubMed
Google Scholar
Loth E, Spooren W, Ham LM, Isaac MB, Auriche-Benichou C, Banaschewski T, Baron-Cohen S, Broich K, Bölte S, Bourgeron T. Identification and validation of biomarkers for autism spectrum disorders. Nat Rev Drug Discov. 2016;15:70–3.
Article
CAS
PubMed
Google Scholar
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: Author; 1994.
Google Scholar
Association AP. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 2000.
Google Scholar
Organization WH. The ICD-10 Classification of mental and behavioural disorders: diagnostic criteria for research. Geneva: WHO; 1993. 2013.
Lord C, Risi S, Lambrecht L, Cook EH, Leventhal BL, DiLavore PC, Pickles A, Rutter M. The Autism Diagnostic Observation Schedule—Generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000;30:205–23.
Article
CAS
PubMed
Google Scholar
Lord C, Rutter M, DiLavore PC, Risi S, Gotham K, Bishop S. Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) manual (part I): modules 1–4. Torrance: Western Psychological Services; 2012.
Google Scholar
Rutter M, Le Couteur A, Lord C. Autism Diagnostic Interview-Revised. Los Angeles: Western Psychological Services; 2003.
Google Scholar
Lord C, Risi S, DiLavore PS, Shulman C, Thurm A, Pickles A. Autism from 2 to 9 years of age. Arch Gen Psychiatry. 2006;63:694–701.
Article
PubMed
Google Scholar
Charman T, Gotham K. Measurement issues: screening and diagnostic instruments for autism spectrum disorders—lessons from research and practise. Child Adolesc Mental Health. 2013;18:52–63.
Article
Google Scholar
Constantino JN, Gruber CP. Social Responsiveness Scale. 2nd ed. Los Angeles: Western Psychological Services; 2012.
Google Scholar
Anagnostou E, Jones N, Huerta M, Halladay AK, Wang P, Scahill L, Horrigan JP, Kasari C, Lord C, Choi D. Measuring social communication behaviors as a treatment endpoint in individuals with autism spectrum disorder. Autism. 2015;19:622–36.
Article
PubMed
Google Scholar
McConachie H, Parr JR, Glod M, Hanratty J, Livingstone N, Oono IP, Robalino S, Baird G, Beresford B, Charman T, Garland D, Green J, Gringras P, Jones G, Law J, Le Couteur AS, Macdonald G, McColl EM, Morris C, Rodgers J, Simonoff E, Terwee CB, Williams K. Systematic review of tools to measure outcomes for young children with autism spectrum disorder. Health Technol Assess. 2015;41:1–506.
Article
Google Scholar
Scahill L, Hallett V, Aman MG, McDougle CJ, Arnold LE, McCracken JT, Tierney E, Deng Y, Dziura J, Vitiello B. Brief report: Social disability in autism spectrum disorder: Results from research units on pediatric psychopharmacology (RUPP) autism network trials. J Autism Dev Disord. 2013;43:739–46.
Article
PubMed
Google Scholar
Baron-Cohen S, Wheelwright S, Skinner R, Martin J, Clubley E. The Autism-Spectrum Quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord. 2001;31:5–17.
Article
CAS
PubMed
Google Scholar
Baron-Cohen S, Hoekstra RA, Knickmeyer R, Wheelwright S. The autism-spectrum quotient (AQ)—adolescent version. J Autism Dev Disord. 2006;36:343–50.
Article
PubMed
Google Scholar
Auyeung B, Baron-Cohen S, Wheelwright S, Allison C. The autism spectrum quotient: children’s version (AQ-Child). J Autism Dev Disord. 2008;38:1230–40.
Article
PubMed
Google Scholar
Hartman CA, Luteijn E, Serra M, Minderaa R. Refinement of the Children’s Social Behavior Questionnaire (CSBQ): an instrument that describes the diverse problems seen in milder forms of PDD. J Autism Dev Disord. 2006;36:325–42.
Article
PubMed
Google Scholar
Horwitz E, Schoevers R, Ketelaars C, Kan C, van Lammeren A, Meesters Y, Spek A, Wouters S, Teunisse J, Cuppen L. Clinical assessment of ASD in adults using self-and other-report: psychometric properties and validity of the Adult Social Behavior Questionnaire (ASBQ). Res Autism Spectr Disord. 2016;24:17–28.
Article
Google Scholar
Tomchek SD, Dunn W. Sensory processing in children with and without autism: a comparative study using the short sensory profile. Am J Occup Ther. 2007;61:190–200.
Article
PubMed
Google Scholar
Bodfish JW, Symons FJ, Parker DE, Lewis MH. Varieties of repetitive behavior in autism: comparisons to mental retardation. J Autism Dev Disord. 2000;30:237–43.
Article
CAS
PubMed
Google Scholar
Gotham K, Pickles A, Lord C. Standardizing ADOS scores for a measure of severity in autism spectrum disorders. J Autism Dev Disord. 2009;39:693–705.
Article
PubMed
Google Scholar
Hus V, Gotham K, Lord C. Standardizing ADOS domain scores: separating severity of social affect and restricted and repetitive behaviors. J Autism Dev Disord. 2014;44:2400–12.
Article
PubMed
PubMed Central
Google Scholar
Dunn W. The sensory profile manual. San Antonio: Psychological Corporation; 1999.
Google Scholar
Wechsler D. Wechsler Abbreviated Scale of Intelligence–Second Edition (WASI-II). San Antonio: NCS Pearson; 2011.
Google Scholar
Wechsler D. Wechsler Intelligence Scale for Children–Third Edition. San Antonio: Psychological Corporation; 1991.
Google Scholar
Wechsler D. Wechsler Intelligence Scale for Children–Fourth Edition. San Antonio: Psychological Corporation; 2003.
Google Scholar
Wechsler D. Wechsler Adult Intelligence Scale– Third Edition. San Antonio: The Psychological Corporation; 1997.
Google Scholar
Wechsler D. Wechsler Adult Intelligence Scale–Fourth Edition. San Antonio: Pearson; 2008.
Google Scholar
Sattler JM. Assessment of children (revised and updated. 3rd ed. San Diego: Jerome M. Sattler; 1992.
Google Scholar
Beck AT, Steer RA, Brown GK. Beck Depression Inventory-II. San Antonio: The Psychological Corporation; 1996.
Google Scholar
Beck JS, Beck AT, Jolly JB, Steer RA. Beck Youth Inventories. 2nd ed. San Antonio: Harcourt Assessment; 2005.
Google Scholar
Beck AT, Steer RA. Beck Anxiety Inventory Manual. San Antonio: The Psychological Corporation Harcourt Brace & Company; 1993.
Google Scholar
StataCorp. Stata statistical software: release 14. College Station: StataCorp LP; 2015.
Google Scholar
Tymms P. Effect sizes in multilevel models. In: Schagen I, Elliot K, editors. But what does it mean? The use of effect sizes in educational research. Slough: National Foundation for Educational Research; 2004.
Google Scholar
Cohen J. A power primer. Psychol Bull. 1992;112:155.
Article
CAS
PubMed
Google Scholar
Jack A, Pelphrey KA. Annual Research Review: Understudied populations within the autism spectrum–current trends and future directions in neuroimaging research. J Child Psychol Psychiatry. J Child Psychol Psychiatry. 2017;58:411–35.
Bal VH, Lord C. Replication of standardized ADOS domain scores in the Simons simplex collection. Autism Res. 2015;8:583–92.
Article
PubMed Central
Google Scholar
Robinson EB, St Pourcain B, Anttila V, Kosmicki JA, Bulik-Sullivan B, Grove J, Maller J, Samocha KE, Sanders SJ, Ripke S. Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nat Genet. 2016;48:552–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Constantino JN, Charman T. Diagnosis of autism spectrum disorder: reconciling the syndrome, its diverse origins, and variation in expression. Lancet Neurol. 2016;15:279–91.
Article
PubMed
Google Scholar
Costello EJ, Copeland W, Angold A. Trends in psychopathology across the adolescent years: what changes when children become adolescents, and when adolescents become adults? J Child Psychol Psychiatry. 2011;52:1015–25.
Article
PubMed
PubMed Central
Google Scholar
Leyfer OT, Folstein SE, Bacalman S, Davis NO, Dinh E, Morgan J, Tager-Flusberg H, Lainhart JE. Comorbid psychiatric disorders in children with autism: interview development and rates of disorders. J Autism Dev Disord. 2006;36:849–61.
Article
PubMed
Google Scholar
Hus V, Bishop S, Gotham K, Huerta M, Lord C. Factors influencing scores on the social responsiveness scale. J Child Psychol Psychiatry. 2013;54:216–24.
Article
PubMed
Google Scholar
Mazefsky CA, Kao J, Oswald DP. Preliminary evidence suggesting caution in the use of psychiatric self-report measures with adolescents with high-functioning autism spectrum disorders. Res Autism Spectr Disord. 2011;5:164–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Achenbach TM, McConaughy SH, Howell CT. Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. Psychol Bull. 1987;101:213–32.
Article
CAS
PubMed
Google Scholar
Baron-Cohen S, Cassidy S, Auyeung B, Allison C, Achoukhi M, Robertson S, Pohl A, Lai M-C. Attenuation of typical sex differences in 800 adults with autism vs. 3,900 controls. PLoS One. 2014;9:e102251.
Article
PubMed
PubMed Central
Google Scholar
Lai M-C, Lombardo MV, Pasco G, Ruigrok AN, Wheelwright SJ, Sadek SA, Chakrabarti B, Baron-Cohen S, Consortium MA. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS One. 2011;6:e20835.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med. 2013;11:1.
Article
Google Scholar
Staal WG, de Krom M, de Jonge MV. Brief report: the dopamine-3-receptor gene (DRD3) is associated with specific repetitive behavior in autism spectrum disorder (ASD). J Autism Dev Disord. 2012;42:885–8.
Article
PubMed
Google Scholar
Lord C, Rutter M, Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994;24:659–85.
Article
CAS
PubMed
Google Scholar