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Table 4 Summary of variation between sites in demographic and behavioural characteristics and level of ASD symptomatology for individuals with ASD only

From: The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation

  Ranges across sites Variance
Minimum Maximum Mean SD Overall mean (SD) Within sites Between sites ICCa x 2 sig. value
Chronological age [years:months] 6:07–19:8 24:5–30:6 14:8–25:0 3:2–6:3 16:7 (5:8) 29.87 9.91 .249 p < .0001
Sex, % of male participants    66.1–80.6   72.3 (4.48) 0.46 <.01 <.001b n.s.c
Verbal IQ 45d–70 130–160 93–110 14–21 97 (19) 382.18 12.61 .031 p < .0001
Nonverbal IQ 45d–68 134–150 93–107 16–23 98 (21) 430.82 24.39 .054 p = .0001
Full-scale IQ 40d–73 128–148 96–105 12–22 98 (20) 373.45 16.35 .042 p = .001
ADI-R
 Social interaction 0–4 24–29 12–19 6–7 17 (7) 42.26 4.33 .093 p < .0001
 Communication 0–3 17–26 9–16 5–5 13 (6) 28.10 4.97 .150 p < .0001
 RRB 0–1 8–12 3–5 2–4 4 (3) 6.06 .85 .122 p < .0001
ADOS—CSS
 Total 1 10c 5–9 2–3 5 (3) 2.77 .35 <.001b n.s.
 SA 1 10c 6–7 2–3 6 (3) 6.88 .11 .016 n.s.
 RRB 1 9–10 4–8 2–3 5 (3) 7.29 .60 .076 p < .0001
Sample sizee 22 159 72 54      
  1. ICC intraclass correlation coefficient, ADI-R Autism Diagnostic Interview-Revised, ADOS CSS Total, SA, RRB Autism Diagnostic Observation Schedule Calibrated Severity Scores for Total, Social Affect and Restricted and Repetitive Behaviours, IQ intelligence quotient, n.s. not significant
  2. aThe ratio of between-site variance to total variance
  3. bICC truncated at zero
  4. cThe highest possible score (i.e. ceiling) on the instrument
  5. dThere are 3 individuals with a full-scale IQ <50 (All ASD)
  6. eSample size variation of individuals with ASD across sites (minimum/maximum, mean and standard deviation of number of participants with ASD recruited at sites)