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  1. Content type: Research

    Theory-of-mind (ToM), the ability to infer people’s thoughts and feelings, is a pivotal skill in effective social interactions. Individuals with autism spectrum disorders (ASD) have been found to have altered ...

    Authors: Rajesh K. Kana, Jose O. Maximo, Diane L. Williams, Timothy A. Keller, Sarah E. Schipul, Vladimir L. Cherkassky, Nancy J. Minshew and Marcel Adam Just

    Citation: Molecular Autism 2015 6:59

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  2. Content type: Research

    Previous studies have demonstrated aggregation of autistic traits in undiagnosed family members of children with autism spectrum disorder (ASD), which has significant implications for ASD risk in their offspri...

    Authors: Thomas W. Frazier, Eric A. Youngstrom, Antonio Y. Hardan, Stelios Georgiades, John N. Constantino and Charis Eng

    Citation: Molecular Autism 2015 6:58

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  3. Content type: Research

    Platelets have been proven to be a useful cellular model to study some neuropathologies, due to the overlapping biological features between neurons and platelets as granule secreting cells. Altered platelet de...

    Authors: Nora Bijl, Chantal Thys, Christine Wittevrongel, Wouter De la Marche, Koenraad Devriendt, Hilde Peeters, Chris Van Geet and Kathleen Freson

    Citation: Molecular Autism 2015 6:57

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  4. Content type: Research

    RBFOX1 (also known as FOX1 or A2BP1) regulates alternative splicing of a variety of transcripts crucial for neuronal functions. Physiological significance of RBFOX1 during brain development is seemingly essent...

    Authors: Nanako Hamada, Hidenori Ito, Ikuko Iwamoto, Rika Morishita, Hidenori Tabata and Koh-ichi Nagata

    Citation: Molecular Autism 2015 6:56

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  5. Content type: Research

    Disruptive mutation in the CHD8 gene is one of the top genetic risk factors in autism spectrum disorders (ASDs). Previous analyses of genome-wide CHD8 occupancy and reduced expression of CHD8 by shRNA knockdown i...

    Authors: Ping Wang, Mingyan Lin, Erika Pedrosa, Anastasia Hrabovsky, Zheng Zhang, Wenjun Guo, Herbert M. Lachman and Deyou Zheng

    Citation: Molecular Autism 2015 6:55

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  6. Content type: Research

    Autism spectrum disorder (ASD) is characterized by atypical development of cortical and subcortical gray matter volume. Subcortical structural changes have been associated with restricted and repetitive behavi...

    Authors: Ian W. Eisenberg, Gregory L. Wallace, Lauren Kenworthy, Stephen J. Gotts and Alex Martin

    Citation: Molecular Autism 2015 6:54

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  7. Content type: Research

    Adolescent females with an autism spectrum disorder (ASD) are an understudied population, yet are also quite vulnerable, due to the increased complexities of social interaction and increased risk for internali...

    Authors: T. Rene Jamison and Jessica Oeth Schuttler

    Citation: Molecular Autism 2015 6:53

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  8. Content type: Research

    Evidence indicates that social functioning deficits and sensory sensitivities in autism spectrum disorder (ASD) are related to atypical sensory integration. The exact mechanisms underlying these integration di...

    Authors: Katie Greenfield, Danielle Ropar, Alastair D. Smith, Mark Carey and Roger Newport

    Citation: Molecular Autism 2015 6:51

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  9. Content type: Research

    Autism spectrum disorder (ASD) is diagnosed much less often in females than males. Emerging behavioral accounts suggest that the clinical presentation of autism is different in females and males, yet research ...

    Authors: Kaustubh Supekar and Vinod Menon

    Citation: Molecular Autism 2015 6:50

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  10. Content type: Research

    Autism spectrum conditions (ASC) are a group of neurodevelopmental conditions characterized by difficulties in social interaction and communication alongside repetitive and stereotyped behaviours. ASC are heri...

    Authors: Varun Warrier, Vivienne Chee, Paula Smith, Bhismadev Chakrabarti and Simon Baron-Cohen

    Citation: Molecular Autism 2015 6:49

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  11. Content type: Research

    Autism spectrum disorder (ASD) traits are continuously distributed throughout the population, and ASD symptoms are also frequently observed in patients with attention-deficit/hyperactivity disorder (ADHD). Bot...

    Authors: Eelco V. van Dongen, Daniel von Rhein, Laurence O’Dwyer, Barbara Franke, Catharina A. Hartman, Dirk J. Heslenfeld, Pieter J. Hoekstra, Jaap Oosterlaan, Nanda Rommelse and Jan Buitelaar

    Citation: Molecular Autism 2015 6:48

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  12. Content type: Research

    Understanding and anticipating others’ mental or emotional states relies on the processing of social cues, such as dynamic facial expressions. Individuals with high-functioning autism (HFA) may process these c...

    Authors: Letizia Palumbo, Hollie G. Burnett and Tjeerd Jellema

    Citation: Molecular Autism 2015 6:47

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  13. Content type: Research

    MicroRNAs are small RNA molecules that regulate the translation of protein from gene transcripts and are a powerful mechanism to regulate gene networks. Next-generation sequencing technologies have produced im...

    Authors: Michal Mor, Stefano Nardone, Dev Sharan Sams and Evan Elliott

    Citation: Molecular Autism 2015 6:46

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  14. Content type: Research

    Autism spectrum disorder (ASD) is highly heritable, yet genome-wide association studies (GWAS), copy number variation screens, and candidate gene association studies have found no single factor accounting for ...

    Authors: Anthony J. Griswold, Nicole D. Dueker, Derek Van Booven, Joseph A. Rantus, James M. Jaworski, Susan H. Slifer, Michael A. Schmidt, William Hulme, Ioanna Konidari, Patrice L. Whitehead, Michael L. Cuccaro, Eden R. Martin, Jonathan L. Haines, John R. Gilbert, John P. Hussman and Margaret A. Pericak-Vance

    Citation: Molecular Autism 2015 6:43

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  15. Content type: Research

    Male predominance is a prominent feature of autism spectrum disorders (ASD), with a reported male to female ratio of 4:1. Because of the overwhelming focus on males, little is known about the neuroanatomical b...

    Authors: Marie Schaer, John Kochalka, Aarthi Padmanabhan, Kaustubh Supekar and Vinod Menon

    Citation: Molecular Autism 2015 6:42

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  16. Content type: Research

    The genetics of autism spectrum disorder (hereafter referred to as “autism”) are rapidly unfolding, with a significant increase in the identification of genes implicated in the disorder. Many of these genes ar...

    Authors: Neha Uppal, Rishi Puri, Frank Yuk, William G M Janssen, Ozlem Bozdagi-Gunal, Hala Harony-Nicolas, Dara L Dickstein, Joseph D Buxbaum and Patrick R Hof

    Citation: Molecular Autism 2015 6:41

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  17. Content type: Research

    There is growing research evidence that subclinical autistic traits are elevated in relatives of individuals with autism spectrum disorder (ASD), continuously distributed in the general population and likely t...

    Authors: I. Magiati, D. A. Goh, S. J. Lim, D. Z. Q. Gan, J. C. L. Leong, C. Allison, S. Baron-Cohen, A. Rifkin-Graboi, B F P. Broekman, S-M. Saw, Y-S. Chong, K. Kwek, P. D. Gluckman, S. B. Lim and M. J. Meaney

    Citation: Molecular Autism 2015 6:40

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  18. Content type: Research

    Autism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microR...

    Authors: Bradley P. Ander, Nicole Barger, Boryana Stamova, Frank R. Sharp and Cynthia M. Schumann

    Citation: Molecular Autism 2015 6:37

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  19. Content type: Viewpoint

    One of the most consistent findings in autism spectrum disorder (ASD) research is a higher rate of ASD diagnosis in males than females. Despite this, remarkably little research has focused on the reasons for t...

    Authors: Alycia K Halladay, Somer Bishop, John N Constantino, Amy M Daniels, Katheen Koenig, Kate Palmer, Daniel Messinger, Kevin Pelphrey, Stephan J Sanders, Alison Tepper Singer, Julie Lounds Taylor and Peter Szatmari

    Citation: Molecular Autism 2015 6:36

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  20. Content type: Research

    The prevalence of autism spectrum disorders (ASDs) is higher in men than in women. The extreme male brain theory proposes that excessive prenatal testosterone activity could be a risk factor for ASDs. However,...

    Authors: Yasuhiro Masuya, Yuko Okamoto, Keisuke Inohara, Yukiko Matsumura, Toru Fujioka, Yuji Wada and Hirotaka Kosaka

    Citation: Molecular Autism 2015 6:34

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  21. Content type: Review

    Several observations support the hypothesis that differences in synaptic and regional cerebral plasticity between the sexes account for the high ratio of males to females in autism. First, males are more susce...

    Authors: Laurent Mottron, Pauline Duret, Sophia Mueller, Robert D Moore, Baudouin Forgeot d’Arc, Sebastien Jacquemont and Lan Xiong

    Citation: Molecular Autism 2015 6:33

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  22. Content type: Research

    The increased male prevalence of autism spectrum disorder (ASD) may be mirrored by the early emergence of sex differences in ASD symptoms and cognitive functioning. The female protective effect hypothesis posi...

    Authors: Daniel S. Messinger, Gregory S. Young, Sara Jane Webb, Sally Ozonoff, Susan E. Bryson, Alice Carter, Leslie Carver, Tony Charman, Katarzyna Chawarska, Suzanne Curtin, Karen Dobkins, Irva Hertz-Picciotto, Ted Hutman, Jana M. Iverson, Rebecca Landa, Charles A. Nelson…

    Citation: Molecular Autism 2015 6:32

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  23. Content type: Research

    Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-...

    Authors: Takashi Itahashi, Takashi Yamada, Hiromi Watanabe, Motoaki Nakamura, Haruhisa Ohta, Chieko Kanai, Akira Iwanami, Nobumasa Kato and Ryu-ichiro Hashimoto

    Citation: Molecular Autism 2015 6:30

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  24. Content type: Research

    Neuroanatomical differences between individuals with and without autism spectrum disorder (ASD) were inconsistent in the literature. Such heterogeneity may substantially originate from age-differential effects.

    Authors: Hsiang-Yuan Lin, Hsing-Chang Ni, Meng-Chuan Lai, Wen-Yih Isaac Tseng and Susan Shur-Fen Gau

    Citation: Molecular Autism 2015 6:29

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  25. Content type: Research

    The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain...

    Authors: Michelle J Chandley, Jessica D Crawford, Attila Szebeni, Katalin Szebeni and Gregory A Ordway

    Citation: Molecular Autism 2015 6:28

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    The Erratum to this article has been published in Molecular Autism 2015 6:38

  26. Content type: Research

    Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on average, protected by sex-differential mechanisms. Under this model, autis...

    Authors: Donna M Werling and Daniel H Geschwind

    Citation: Molecular Autism 2015 6:27

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  27. Content type: Research

    Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion...

    Authors: Christine Wu Nordahl, Ana-Maria Iosif, Gregory S Young, Lee Michael Perry, Robert Dougherty, Aaron Lee, Deana Li, Michael H Buonocore, Tony Simon, Sally Rogers, Brian Wandell and David G Amaral

    Citation: Molecular Autism 2015 6:26

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    The Erratum to this article has been published in Molecular Autism 2015 6:39

  28. Content type: Research

    A 4:1 male to female sex bias has consistently been observed in autism spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective effect (FPE) may account for part of this bias; h...

    Authors: Jake Gockley, A Jeremy Willsey, Shan Dong, Joseph D Dougherty, John N Constantino and Stephan J Sanders

    Citation: Molecular Autism 2015 6:25

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  29. Content type: Research

    Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant impairment in reciprocal social interactions and communication coupled with stereotyped, repetitive behaviors and r...

    Authors: Valerie W Hu, Tewarit Sarachana, Rachel M Sherrard and Kristen M Kocher

    Citation: Molecular Autism 2015 6:7

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  30. Content type: Research

    SHANK proteins are crucial for the formation and plasticity of excitatory synapses. Although mutations in all three SHANK genes are associated with autism spectrum disorder (ASD), SHANK3 appears to be the major A...

    Authors: Daniela M Cochoy, Alexander Kolevzon, Yuji Kajiwara, Michael Schoen, Maria Pascual-Lucas, Stacey Lurie, Joseph D Buxbaum, Tobias M Boeckers and Michael J Schmeisser

    Citation: Molecular Autism 2015 6:23

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  31. Content type: Research

    Difficulties in recognizing emotions and mental states are central characteristics of autism spectrum conditions (ASC). However, emotion recognition (ER) studies have focused mostly on recognition of the six ‘...

    Authors: Ofer Golan, Yana Sinai-Gavrilov and Simon Baron-Cohen

    Citation: Molecular Autism 2015 6:22

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  32. Content type: Research

    Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with high heritability. Recent findings support a highly heterogeneous and complex genetic etiology including rare de novo and inherited...

    Authors: Marta Codina-Solà, Benjamín Rodríguez-Santiago, Aïda Homs, Javier Santoyo, Maria Rigau, Gemma Aznar-Laín, Miguel del Campo, Blanca Gener, Elisabeth Gabau, María Pilar Botella, Armand Gutiérrez-Arumí, Guillermo Antiñolo, Luis Alberto Pérez-Jurado and Ivon Cuscó

    Citation: Molecular Autism 2015 6:21

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  33. Content type: Research

    Apparently balanced chromosomal rearrangements can be associated with an abnormal phenotype, including intellectual disability and autism spectrum disorder (ASD). Genome-wide microarrays reveal cryptic genomic...

    Authors: Anne-Claude Tabet, Alain Verloes, Marion Pilorge, Elsa Delaby, Richard Delorme, Gudrun Nygren, Françoise Devillard, Marion Gérard, Sandrine Passemard, Delphine Héron, Jean-Pierre Siffroi, Aurelia Jacquette, Andrée Delahaye, Laurence Perrin, Céline Dupont, Azzedine Aboura…

    Citation: Molecular Autism 2015 6:19

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  34. Content type: Research

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting more than 1% of children. It is characterized by social communication deficits and repetitive behaviors/restricted interests. In the ab...

    Authors: Deepali Mankad, Annie Dupuis, Sharon Smile, Wendy Roberts, Jessica Brian, Toni Lui, Lisa Genore, Dina Zaghloul, Alana Iaboni, Peggy Margaret A Marcon and Evdokia Anagnostou

    Citation: Molecular Autism 2015 6:18

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  35. Content type: Research

    Autism spectrum disorder (ASD) has a complex genetic etiology. Some symptoms and mutated genes, including neuroligin (NLGN), neurexin (NRXN), and SH3 and multiple ankyrin repeat domains protein (SHANK), are share...

    Authors: Eriko Fujita-Jimbo, Yuko Tanabe, Zhiling Yu, Karin Kojima, Masato Mori, Hong Li, Sadahiko Iwamoto, Takanori Yamagata, Mariko Y Momoi and Takashi Momoi

    Citation: Molecular Autism 2015 6:17

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  36. Content type: Research

    The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals w...

    Authors: Brittany G Travers, Do P M Tromp, Nagesh Adluru, Nicholas Lange, Dan Destiche, Chad Ennis, Jared A Nielsen, Alyson L Froehlich, Molly B D Prigge, P Thomas Fletcher, Jeffrey S Anderson, Brandon A Zielinski, Erin D Bigler, Janet E Lainhart and Andrew L Alexander

    Citation: Molecular Autism 2015 6:15

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  37. Content type: Research

    The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN).

    Authors: Søren Nielsen, Henrik Anckarsäter, Carina Gillberg, Christopher Gillberg, Maria Råstam and Elisabet Wentz

    Citation: Molecular Autism 2015 6:14

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  38. Content type: Research

    An important minority of school-aged autistic children, often characterized as ‘nonverbal’ or ‘minimally verbal,’ displays little or no spoken language. These children are at risk of being judged ‘low-function...

    Authors: Valérie Courchesne, Andrée-Anne S Meilleur, Marie-Pier Poulin-Lord, Michelle Dawson and Isabelle Soulières

    Citation: Molecular Autism 2015 6:12

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