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  1. Content type: Research

    While models of autism spectrum conditions (ASC) are emerging at the genetic level of analysis, clear models at higher levels of analysis, such as neuroanatomy, are lacking. Here we examine agenesis of the cor...

    Authors: Michael V Lombardo, Bhismadev Chakrabarti, Meng-Chuan Lai and Simon Baron-Cohen

    Citation: Molecular Autism 2012 3:14

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  2. Content type: Research

    Autism spectrum disorders (ASD) are defined by impairment in reciprocal social interaction and flexible adaptation to the environment. This study compared physiological stress in children with and without ASD ...

    Authors: Blythe A Corbett, Clayton W Schupp and Kimberly E Lanni

    Citation: Molecular Autism 2012 3:13

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  3. Content type: Research

    Mitochondrial dysfunction (MtD) has been observed in approximately five percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-dependent processes such as neurodevelopment, th...

    Authors: Ayyappan Anitha, Kazuhiko Nakamura, Ismail Thanseem, Kazuo Yamada, Yoshimi Iwayama, Tomoko Toyota, Hideo Matsuzaki, Taishi Miyachi, Satoru Yamada, Masatsugu Tsujii, Kenji J Tsuchiya, Kaori Matsumoto, Yasuhide Iwata, Katsuaki Suzuki, Hironobu Ichikawa, Toshiro Sugiyama…

    Citation: Molecular Autism 2012 3:12

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  4. Content type: Research

    Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein receptors Vldlr and Lrp8. Reeler mutant mice display severe brain morphological defects ...

    Authors: Keiko Iwata, Nobuo Izumo, Hideo Matsuzaki, Takayuki Manabe, Yukiko Ishibashi, Yukio Ichitani, Kazuo Yamada, Ismail Thanseem, Ayyappan Anitha, Mahesh Mundalil Vasu, Chie Shimmura, Tomoyasu Wakuda, Yosuke Kameno, Taro Takahashi, Yasuhide Iwata, Katsuaki Suzuki…

    Citation: Molecular Autism 2012 3:11

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  5. Content type: Research

    Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied by restricted and repetitive behaviors. Whil...

    Authors: Lambertus Klei, Stephan J Sanders, Michael T Murtha, Vanessa Hus, Jennifer K Lowe, A Jeremy Willsey, Daniel Moreno-De-Luca, Timothy W Yu, Eric Fombonne, Daniel Geschwind, Dorothy E Grice, David H Ledbetter, Catherine Lord, Shrikant M Mane, Christa Lese Martin, Donna M Martin…

    Citation: Molecular Autism 2012 3:9

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  6. Content type: Research

    Autism spectrum disorder (ASD) is highly heritable, but the genetic risk factors for it remain largely unknown. Although structural variants with large effect sizes may explain up to 15% ASD, genome-wide assoc...

    Authors: Karyn Meltz Steinberg, Dhanya Ramachandran, Viren C Patel, Amol C Shetty, David J Cutler and Michael E Zwick

    Citation: Molecular Autism 2012 3:8

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  7. Content type: Research

    Social motivation theory suggests that deficits in social reward processing underlie social impairments in autism spectrum disorders (ASD). However, the extent to which abnormalities in reward processing gener...

    Authors: Sonja Delmonte, Joshua H Balsters, Jane McGrath, Jacqueline Fitzgerald, Sean Brennan, Andrew J Fagan and Louise Gallagher

    Citation: Molecular Autism 2012 3:7

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  8. Content type: Short report

    Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene f...

    Authors: Teresa Tavassoli, Bonnie Auyeung, Laura C Murphy, Simon Baron-Cohen and Bhismadev Chakrabarti

    Citation: Molecular Autism 2012 3:6

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  9. Content type: Research

    Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability (ID), as well as the most frequent monogenic cause of autism spectrum disorder (ASD). Men with FXS exhibit ID, often assoc...

    Authors: Pauline Chaste, Catalina Betancur, Marion Gérard-Blanluet, Anne Bargiacchi, Suzanne Kuzbari, Séverine Drunat, Marion Leboyer, Thomas Bourgeron and Richard Delorme

    Citation: Molecular Autism 2012 3:5

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  10. Content type: Research

    Autism spectrum disorder is a severe early onset neurodevelopmental disorder with high heritability but significant heterogeneity. Traditional genome-wide approaches to test for an association of common varian...

    Authors: Lea K Davis, Eric R Gamazon, Emily Kistner-Griffin, Judith A Badner, Chunyu Liu, Edwin H Cook, James S Sutcliffe and Nancy J Cox

    Citation: Molecular Autism 2012 3:3

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  11. Content type: Research

    Autism spectrum disorders (ASD) represent a group of neurodevelopmental disorders characterized by a core set of social-communicative and behavioral impairments. Gamma-aminobutyric acid (GABA) is the major inh...

    Authors: Dale J Hedges, Kara L Hamilton-Nelson, Stephanie J Sacharow, Laura Nations, Gary W Beecham, Zhanna M Kozhekbaeva, Brittany L Butler, Holly N Cukier, Patrice L Whitehead, Deqiong Ma, James M Jaworski, Lubov Nathanson, Joycelyn M Lee, Stephen L Hauser, Jorge R Oksenberg, Michael L Cuccaro…

    Citation: Molecular Autism 2012 3:2

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  12. Content type: Short report

    There is interest in defining mouse neurobiological phenotypes useful for studying autism spectrum disorders (ASD) in both forward and reverse genetic approaches. A recurrent focus has been on high-order behav...

    Authors: Joseph D Buxbaum, Catalina Betancur, Ozlem Bozdagi, Nate P Dorr, Gregory A Elder and Patrick R Hof

    Citation: Molecular Autism 2012 3:1

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  13. Content type: Research

    Duplication of chromosome 15q11-q13 (dup15q) accounts for approximately 3% of autism cases. Chromosome 15q11-q13 contains imprinted genes necessary for normal mammalian neurodevelopment controlled by a differe...

    Authors: Haley A Scoles, Nora Urraca, Samuel W Chadwick, Lawrence T Reiter and Janine M LaSalle

    Citation: Molecular Autism 2011 2:19

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  14. Content type: Research

    Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong genetic component. The skewed prevalence toward males and evidence suggestive of linkage to the X chromosome in some studie...

    Authors: Ren-Hua Chung, Deqiong Ma, Kai Wang, Dale J Hedges, James M Jaworski, John R Gilbert, Michael L Cuccaro, Harry H Wright, Ruth K Abramson, Ioanna Konidari, Patrice L Whitehead, Gerard D Schellenberg, Hakon Hakonarson, Jonathan L Haines, Margaret A Pericak-Vance and Eden R Martin

    Citation: Molecular Autism 2011 2:18

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  15. Content type: Research

    The inheritance pattern in most cases of autism is complex. The risk of autism is increased in siblings of children with autism and previous studies have indicated that the level of risk can be further identif...

    Authors: Jerome Carayol, Gerard D Schellenberg, Beth Dombroski, Emmanuelle Genin, Francis Rousseau and Geraldine Dawson

    Citation: Molecular Autism 2011 2:17

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  16. Content type: Short report

    The neurobiological basis of autism remains poorly understood. The diagnosis of autism is based solely on behavioural characteristics because there are currently no reliable biological markers. To test whether...

    Authors: Keiko Iwata, Hideo Matsuzaki, Taishi Miyachi, Chie Shimmura, Shiro Suda, Kenji J Tsuchiya, Kaori Matsumoto, Katsuaki Suzuki, Yasuhide Iwata, Kazuhiko Nakamura, Masatsugu Tsujii, Toshirou Sugiyama, Kohji Sato and Norio Mori

    Citation: Molecular Autism 2011 2:16

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  17. Content type: Research

    The brain develops in concert and in coordination with the developing facial tissues, with each influencing the development of the other and sharing genetic signaling pathways. Autism spectrum disorders (ASDs)...

    Authors: Kristina Aldridge, Ian D George, Kimberly K Cole, Jordan R Austin, T Nicole Takahashi, Ye Duan and Judith H Miles

    Citation: Molecular Autism 2011 2:15

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  18. Content type: Short report

    Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we ex...

    Authors: Shiro Suda, Keiko Iwata, Chie Shimmura, Yosuke Kameno, Ayyappan Anitha, Ismail Thanseem, Kazuhiko Nakamura, Hideo Matsuzaki, Kenji J Tsuchiya, Genichi Sugihara, Yasuhide Iwata, Katsuaki Suzuki, Keita Koizumi, Haruhiro Higashida, Nori Takei and Norio Mori

    Citation: Molecular Autism 2011 2:14

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  19. Content type: Research

    Immune anomalies have been documented in individuals with autism spectrum disorders (ASDs) and their family members. It is unknown whether the maternal immune profile during pregnancy is associated with the ri...

    Authors: Paula E Goines, Lisa A Croen, Daniel Braunschweig, Cathleen K Yoshida, Judith Grether, Robin Hansen, Martin Kharrazi, Paul Ashwood and Judy Van de Water

    Citation: Molecular Autism 2011 2:13

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  20. Content type: Research

    Stimulus-related γ-band oscillations, which may be related to perceptual binding, are reduced in people with autism spectrum disorders (ASD). The purpose of this study was to examine auditory transient and ste...

    Authors: Donald C Rojas, Peter D Teale, Keeran Maharajh, Eugene Kronberg, Katie Youngpeter, Lisa B Wilson, Alissa Wallace and Susan Hepburn

    Citation: Molecular Autism 2011 2:11

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  21. Content type: Research

    The autism spectrum disorders (ASDs) are complex neurodevelopmental disorders that result in severe and pervasive impairment in the development of reciprocal social interaction and verbal and nonverbal communi...

    Authors: Yuka Yasuda, Ryota Hashimoto, Hidenaga Yamamori, Kazutaka Ohi, Motoyuki Fukumoto, Satomi Umeda-Yano, Ikuko Mohri, Akira Ito, Masako Taniike and Masatoshi Takeda

    Citation: Molecular Autism 2011 2:9

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  22. Content type: Research

    SLC25A12 was previously identified by a linkage-directed association analysis in autism. In this study, we investigated the relationship between three SLC25A12 single nucleotide polymorphisms (SNPs) (rs2056202, r...

    Authors: Soo-Jeong Kim, Raquel M Silva, Cindi G Flores, Suma Jacob, Stephen Guter, Gregory Valcante, Annette M Zaytoun, Edwin H Cook and Judith A Badner

    Citation: Molecular Autism 2011 2:8

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  23. Content type: Research

    The inbred mouse strain BTBR T+ tf/J (BTBR) exhibits behavioral deficits that mimic the core deficits of autism. Neuroanatomically, the BTBR strain is also characterized by a complete absence of the corpus cal...

    Authors: Diane T Stephenson, Sharon M O'Neill, Sapna Narayan, Aadhya Tiwari, Elizabeth Arnold, Harry D Samaroo, Fu Du, Robert H Ring, Brian Campbell, Mathew Pletcher, Vidita A Vaidya and Daniel Morton

    Citation: Molecular Autism 2011 2:7

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  24. Content type: Research

    Fragile X syndrome is caused by loss of function of the fragile X mental retardation 1 (FMR1) gene and shares multiple phenotypes with autism. We have previously found reduced expression of the protein product of...

    Authors: S Hossein Fatemi and Timothy D Folsom

    Citation: Molecular Autism 2011 2:6

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  25. Content type: Research

    Autism is a neurodevelopmental disorder characterized by impairments in social interaction and deficits in verbal and nonverbal communication, together with the presence of repetitive behaviors or a limited re...

    Authors: Sharifia Wills, Christy C Rossi, Jeffrey Bennett, Veronica Martinez-Cerdeño, Paul Ashwood, David G Amaral and Judy Van de Water

    Citation: Molecular Autism 2011 2:5

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  26. Content type: Research

    Arginine vasopressin (AVP) has been hypothesized to play a role in aetiology of autism based on a demonstrated involvement in the regulation of social behaviours. The arginine vasopressin receptor 1A gene (AVPR1A

    Authors: Katherine E Tansey, Matthew J Hill, Lynne E Cochrane, Michael Gill, Richard JL Anney and Louise Gallagher

    Citation: Molecular Autism 2011 2:3

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  27. Content type: Research

    Fragile X syndrome (FXS) is the most common inherited form of intellectual disability, and is the most common single-gene disorder known to be associated with autism. Despite recent advances in functional neur...

    Authors: Claudia M Greco, Celestine S Navarro, Michael R Hunsaker, Izumi Maezawa, John F Shuler, Flora Tassone, Mary Delany, Jacky W Au, Robert F Berman, Lee-Way Jin, Cynthia Schumann, Paul J Hagerman and Randi J Hagerman

    Citation: Molecular Autism 2011 2:2

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  28. Content type: Research

    Genome-wide Association Studies (GWAS) have proved invaluable for the identification of disease susceptibility genes. However, the prioritization of candidate genes and regions for follow-up studies often prov...

    Authors: John P Hussman, Ren-Hua Chung, Anthony J Griswold, James M Jaworski, Daria Salyakina, Deqiong Ma, Ioanna Konidari, Patrice L Whitehead, Jeffery M Vance, Eden R Martin, Michael L Cuccaro, John R Gilbert, Jonathan L Haines and Margaret A Pericak-Vance

    Citation: Molecular Autism 2011 2:1

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  29. Content type: Research

    SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the synapse, including components of α-amino-3-hydroxyl-5-...

    Authors: Ozlem Bozdagi, Takeshi Sakurai, Danae Papapetrou, Xiaobin Wang, Dara L Dickstein, Nagahide Takahashi, Yuji Kajiwara, Mu Yang, Adam M Katz, Maria Luisa Scattoni, Mark J Harris, Roheeni Saxena, Jill L Silverman, Jacqueline N Crawley, Qiang Zhou, Patrick R Hof…

    Citation: Molecular Autism 2010 1:15

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  30. Content type: Short report

    Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus implicated in prostate cancer and chronic fatigue syndrome (CFS). Press releases have suggested that it could contribute to autism spectrum...

    Authors: Brent C Satterfield, Rebecca A Garcia, Fiorella Gurrieri and Charles E Schwartz

    Citation: Molecular Autism 2010 1:14

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  31. Content type: Research

    The hallmark characteristic of autism is impaired reciprocal social interaction. While children find social interaction stress-reducing, many children with autism may find social interaction stress-inducing. T...

    Authors: Blythe A Corbett, Clayton W Schupp, David Simon, Niles Ryan and Sally Mendoza

    Citation: Molecular Autism 2010 1:13

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  32. Content type: Research

    The Autism Spectrum Quotient (AQ) is a self-report questionnaire for quantifying autistic traits. This study tests whether the AQ can differentiate between parents of children with an autism spectrum condition...

    Authors: Sally Wheelwright, Bonnie Auyeung, Carrie Allison and Simon Baron-Cohen

    Citation: Molecular Autism 2010 1:10

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  33. Content type: Research

    HOXB1 plays a major role in brainstem morphogenesis and could partly determine the cranial circumference in conjunction with HOXA1. In our sample, HOXA1 alleles significantly influence head growth rates both in a...

    Authors: Lucia A Muscarella, Vito Guarnieri, Roberto Sacco, Paolo Curatolo, Barbara Manzi, Riccardo Alessandrelli, Grazia Giana, Roberto Militerni, Carmela Bravaccio, Carlo Lenti, Monica Saccani, Cindy Schneider, Raun Melmed, Leonardo D'Agruma and Antonio M Persico

    Citation: Molecular Autism 2010 1:9

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  34. Content type: Research

    Autism Spectrum Disorders (ASD) are phenotypically heterogeneous, characterized by impairments in the development of communication and social behaviour and the presence of repetitive behaviour and restricted inte...

    Authors: Hilary Coon, Michele E Villalobos, Reid J Robison, Nicola J Camp, Dale S Cannon, Kristina Allen-Brady, Judith S Miller and William M McMahon

    Citation: Molecular Autism 2010 1:8

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  35. Content type: Research

    Autism spectrum disorders (ASDs) are a group of highly heritable neurodevelopmental disorders which are characteristically comprised of impairments in social interaction, communication and restricted interests...

    Authors: Inês Sousa, Taane G Clark, Richard Holt, Alistair T Pagnamenta, Erik J Mulder, Ruud B Minderaa, Anthony J Bailey, Agatino Battaglia, Sabine M Klauck, Fritz Poustka and Anthony P Monaco

    Citation: Molecular Autism 2010 1:7

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  36. Content type: Editorial

    Many psychiatric conditions and traits are associated with significant heritability. Genetic risk for psychiatric conditions encompass rare variants, identified due to major effect, as well as common variants,...

    Authors: Joseph D Buxbaum, Simon Baron-Cohen and Bernie Devlin

    Citation: Molecular Autism 2010 1:6

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  37. Content type: Research

    The 15q24 microdeletion syndrome has been recently described as a recurrent, submicroscopic genomic imbalance found in individuals with intellectual disability, typical facial appearance, hypotonia, and digita...

    Authors: L Alison McInnes, Alisa Nakamine, Marion Pilorge, Tracy Brandt, Patricia Jiménez González, Marietha Fallas, Elina R Manghi, Lisa Edelmann, Joseph Glessner, Hakon Hakonarson, Catalina Betancur and Joseph D Buxbaum

    Citation: Molecular Autism 2010 1:5

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  38. Content type: Research

    Autism is a complex disorder characterized by deficits involving communication, social interaction, and repetitive and restrictive patterns of behavior. Twin studies have shown that autism is strongly heritabl...

    Authors: Jerome Carayol, Gerard D Schellenberg, Frederic Tores, Jörg Hager, Andreas Ziegler and Geraldine Dawson

    Citation: Molecular Autism 2010 1:4

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  39. Content type: Research

    It has been suggested that efforts to identify genetic risk markers of autism spectrum disorder (ASD) would benefit from the analysis of more narrowly defined ASD phenotypes. Previous research indicates that '...

    Authors: Dale S Cannon, Judith S Miller, Reid J Robison, Michele E Villalobos, Natalie K Wahmhoff, Kristina Allen-Brady, William M McMahon and Hilary Coon

    Citation: Molecular Autism 2010 1:3

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  40. Content type: Research

    Autism is a neurodevelopmental disorder which is known to have a strong genetic component and is most likely oligogenic. However, the necessary role of environmental factors has been well documented. Prior res...

    Authors: Roksana Sasanfar, Stephen A Haddad, Ala Tolouei, Majid Ghadami, Dongmei Yu and Susan L Santangelo

    Citation: Molecular Autism 2010 1:2

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