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  1. Autism spectrum disorders (ASDs) are relatively common neurodevelopmental conditions whose biological basis has been incompletely determined. Several biochemical markers have been associated with ASDs, but the...

    Authors: Luigi Boccuto, Chin-Fu Chen, Ayla R Pittman, Cindy D Skinner, Heather J McCartney, Kelly Jones, Barry R Bochner, Roger E Stevenson and Charles E Schwartz

    Citation: Molecular Autism 2013 4:16

    Content type: Research

    Published on:

  2. Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by loss of function of the fragile X mental retardation protein. Recent animal studies suggest that upregulated downstream ...

    Authors: Talakad G Lohith, Emily K Osterweil, Masahiro Fujita, Kimberly J Jenko, Mark F Bear and Robert B Innis

    Citation: Molecular Autism 2013 4:15

    Content type: Research

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  3. We have recently identified the nuclear hormone receptor RORA (retinoic acid-related orphan receptor-alpha) as a novel candidate gene for autism spectrum disorder (ASD). Our independent cohort studies have consis...

    Authors: Tewarit Sarachana and Valerie W Hu

    Citation: Molecular Autism 2013 4:14

    Content type: Research

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  4. Since Kanner’s first description of autism there have been a number of changes in approaches to diagnosis with certain key continuities . Since the Fourth edition of the Diagnostic and Statistical Manual (DSM-...

    Authors: Fred R Volkmar and Brian Reichow

    Citation: Molecular Autism 2013 4:13

    Content type: Review

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  5. We are fortunate to have invited commentaries from the laboratories of Dr Cathy Lord and Dr Fred Volkmar offering their perspectives on the new Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 cri...

    Authors: Joseph D Buxbaum and Simon Baron-Cohen

    Citation: Molecular Autism 2013 4:11

    Content type: Editorial

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  6. Haploinsufficiency of SHANK3, due to either hemizygous gene deletion (termed 22q13 deletion syndrome or Phelan-McDermid syndrome) or to gene mutation, accounts for about 0.5% of the cases of autism spectrum disor...

    Authors: Ozlem Bozdagi, Teresa Tavassoli and Joseph D Buxbaum

    Citation: Molecular Autism 2013 4:9

    Content type: Short report

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  7. Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental disorders that affect 1 in 88 children in the US. Previous exome sequencing studies on family trios have implicated a role for...

    Authors: Lingling Shi, Xu Zhang, Ryan Golhar, Frederick G Otieno, Mingze He, Cuiping Hou, Cecilia Kim, Brendan Keating, Gholson J Lyon, Kai Wang and Hakon Hakonarson

    Citation: Molecular Autism 2013 4:8

    Content type: Research

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  8. The prevalence of autism spectrum conditions (ASC) is 1% in developed countries, but little data are available from mainland China, Hong Kong and Taiwan. This study synthesizes evidence relating to the prevale...

    Authors: Xiang Sun, Carrie Allison, Fiona E Matthews, Stephen J Sharp, Bonnie Auyeung, Simon Baron-Cohen and Carol Brayne

    Citation: Molecular Autism 2013 4:7

    Content type: Review

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  9. Accumulating evidence suggests that dysfunction in the glutamatergic system may underlie the pathophysiology of autism. The anterior cingulate cortex (ACC) has been implicated in autism as well as in glutamate...

    Authors: Chie Shimmura, Katsuaki Suzuki, Yasuhide Iwata, Kenji J Tsuchiya, Koji Ohno, Hideo Matsuzaki, Keiko Iwata, Yosuke Kameno, Taro Takahashi, Tomoyasu Wakuda, Kazuhiko Nakamura, Kenji Hashimoto and Norio Mori

    Citation: Molecular Autism 2013 4:6

    Content type: Research

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  10. Autism spectrum disorder (ASD) is reported in 30 to 60% of patients with tuberous sclerosis complex (TSC) but shared genetic mechanisms that exist between TSC-associated ASD and idiopathic ASD have yet to be d...

    Authors: Samira Bahl, Colby Chiang, Roberta L Beauchamp, Benjamin M Neale, Mark J Daly, James F Gusella, Michael E Talkowski and Vijaya Ramesh

    Citation: Molecular Autism 2013 4:5

    Content type: Research

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  11. Vision in people with autism spectrum conditions (ASC) is reported to be different from people without ASC, but the neural level at which the differences begin to occur is not yet known. Here we examine two va...

    Authors: Keziah Latham, Susana L Chung, Peter M Allen, Teresa Tavassoli and Simon Baron-Cohen

    Citation: Molecular Autism 2013 4:4

    Content type: Short report

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  12. Mutations in MECP2 encoding methyl-CpG-binding protein 2 (MeCP2) cause the X-linked neurodevelopmental disorder Rett syndrome. Rett syndrome patients exhibit neurological symptoms that include irregular breathing...

    Authors: Dag H Yasui, Huichun Xu, Keith W Dunaway, Janine M LaSalle, Lee-Way Jin and Izumi Maezawa

    Citation: Molecular Autism 2013 4:3

    Content type: Research

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  13. Autism Spectrum Conditions (ASC) are a set of pervasive neurodevelopmental conditions characterized by a wide range of lifelong signs and symptoms. Recent explanatory models of autism propose abnormal neural c...

    Authors: Ana Catarino, Alexandre Andrade, Owen Churches, Adam P Wagner, Simon Baron-Cohen and Howard Ring

    Citation: Molecular Autism 2013 4:1

    Content type: Research

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  14. Alternation of synaptic homeostasis is a biological process whose disruption might predispose children to autism spectrum disorders (ASD). Calcium channel genes (CCG) contribute to modulating neuronal function...

    Authors: Ake Tzu-Hui Lu, Xiaoxian Dai, Julian A Martinez-Agosto and Rita M Cantor

    Citation: Molecular Autism 2012 3:18

    Content type: Research

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  15. Studies of prenatal exposure to sex steroid hormones predict autistic traits in children at 18 to 24 and at 96 months of age. However, it is not known whether postnatal exposure to these hormones has a similar...

    Authors: Bonnie Auyeung, Jag Ahluwalia, Lynn Thomson, Kevin Taylor, Gerald Hackett, Kieran J O’Donnell and Simon Baron-Cohen

    Citation: Molecular Autism 2012 3:17

    Content type: Short report

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  16. There are no effective medications for the treatment of social cognition/function deficits in autism spectrum disorder (ASD), and adult intervention literature in this area is sparse. Emerging data from animal...

    Authors: Evdokia Anagnostou, Latha Soorya, William Chaplin, Jennifer Bartz, Danielle Halpern, Stacey Wasserman, A Ting Wang, Lauren Pepa, Nadia Tanel, Azadeh Kushki and Eric Hollander

    Citation: Molecular Autism 2012 3:16

    Content type: Research

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  17. Reduced activity during cognitively demanding tasks has been reported in the default mode network in typically developing controls and individuals with autism. However, no study has investigated the default mo...

    Authors: Michael D Spencer, Lindsay R Chura, Rosemary J Holt, John Suckling, Andrew J Calder, Edward T Bullmore and Simon Baron-Cohen

    Citation: Molecular Autism 2012 3:15

    Content type: Short report

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  18. While models of autism spectrum conditions (ASC) are emerging at the genetic level of analysis, clear models at higher levels of analysis, such as neuroanatomy, are lacking. Here we examine agenesis of the cor...

    Authors: Michael V Lombardo, Bhismadev Chakrabarti, Meng-Chuan Lai and Simon Baron-Cohen

    Citation: Molecular Autism 2012 3:14

    Content type: Research

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  19. Autism spectrum disorders (ASD) are defined by impairment in reciprocal social interaction and flexible adaptation to the environment. This study compared physiological stress in children with and without ASD ...

    Authors: Blythe A Corbett, Clayton W Schupp and Kimberly E Lanni

    Citation: Molecular Autism 2012 3:13

    Content type: Research

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  20. Mitochondrial dysfunction (MtD) has been observed in approximately five percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-dependent processes such as neurodevelopment, th...

    Authors: Ayyappan Anitha, Kazuhiko Nakamura, Ismail Thanseem, Kazuo Yamada, Yoshimi Iwayama, Tomoko Toyota, Hideo Matsuzaki, Taishi Miyachi, Satoru Yamada, Masatsugu Tsujii, Kenji J Tsuchiya, Kaori Matsumoto, Yasuhide Iwata, Katsuaki Suzuki, Hironobu Ichikawa, Toshiro Sugiyama…

    Citation: Molecular Autism 2012 3:12

    Content type: Research

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  21. Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein receptors Vldlr and Lrp8. Reeler mutant mice display severe brain morphological defects ...

    Authors: Keiko Iwata, Nobuo Izumo, Hideo Matsuzaki, Takayuki Manabe, Yukiko Ishibashi, Yukio Ichitani, Kazuo Yamada, Ismail Thanseem, Ayyappan Anitha, Mahesh Mundalil Vasu, Chie Shimmura, Tomoyasu Wakuda, Yosuke Kameno, Taro Takahashi, Yasuhide Iwata, Katsuaki Suzuki…

    Citation: Molecular Autism 2012 3:11

    Content type: Research

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  22. Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied by restricted and repetitive behaviors. Whil...

    Authors: Lambertus Klei, Stephan J Sanders, Michael T Murtha, Vanessa Hus, Jennifer K Lowe, A Jeremy Willsey, Daniel Moreno-De-Luca, Timothy W Yu, Eric Fombonne, Daniel Geschwind, Dorothy E Grice, David H Ledbetter, Catherine Lord, Shrikant M Mane, Christa Lese Martin, Donna M Martin…

    Citation: Molecular Autism 2012 3:9

    Content type: Research

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  23. Autism spectrum disorder (ASD) is highly heritable, but the genetic risk factors for it remain largely unknown. Although structural variants with large effect sizes may explain up to 15% ASD, genome-wide assoc...

    Authors: Karyn Meltz Steinberg, Dhanya Ramachandran, Viren C Patel, Amol C Shetty, David J Cutler and Michael E Zwick

    Citation: Molecular Autism 2012 3:8

    Content type: Research

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  24. Social motivation theory suggests that deficits in social reward processing underlie social impairments in autism spectrum disorders (ASD). However, the extent to which abnormalities in reward processing gener...

    Authors: Sonja Delmonte, Joshua H Balsters, Jane McGrath, Jacqueline Fitzgerald, Sean Brennan, Andrew J Fagan and Louise Gallagher

    Citation: Molecular Autism 2012 3:7

    Content type: Research

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  25. Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene f...

    Authors: Teresa Tavassoli, Bonnie Auyeung, Laura C Murphy, Simon Baron-Cohen and Bhismadev Chakrabarti

    Citation: Molecular Autism 2012 3:6

    Content type: Short report

    Published on:

  26. Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability (ID), as well as the most frequent monogenic cause of autism spectrum disorder (ASD). Men with FXS exhibit ID, often assoc...

    Authors: Pauline Chaste, Catalina Betancur, Marion Gérard-Blanluet, Anne Bargiacchi, Suzanne Kuzbari, Séverine Drunat, Marion Leboyer, Thomas Bourgeron and Richard Delorme

    Citation: Molecular Autism 2012 3:5

    Content type: Research

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  27. Autism spectrum disorder is a severe early onset neurodevelopmental disorder with high heritability but significant heterogeneity. Traditional genome-wide approaches to test for an association of common varian...

    Authors: Lea K Davis, Eric R Gamazon, Emily Kistner-Griffin, Judith A Badner, Chunyu Liu, Edwin H Cook, James S Sutcliffe and Nancy J Cox

    Citation: Molecular Autism 2012 3:3

    Content type: Research

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  28. Autism spectrum disorders (ASD) represent a group of neurodevelopmental disorders characterized by a core set of social-communicative and behavioral impairments. Gamma-aminobutyric acid (GABA) is the major inh...

    Authors: Dale J Hedges, Kara L Hamilton-Nelson, Stephanie J Sacharow, Laura Nations, Gary W Beecham, Zhanna M Kozhekbaeva, Brittany L Butler, Holly N Cukier, Patrice L Whitehead, Deqiong Ma, James M Jaworski, Lubov Nathanson, Joycelyn M Lee, Stephen L Hauser, Jorge R Oksenberg, Michael L Cuccaro…

    Citation: Molecular Autism 2012 3:2

    Content type: Research

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  29. There is interest in defining mouse neurobiological phenotypes useful for studying autism spectrum disorders (ASD) in both forward and reverse genetic approaches. A recurrent focus has been on high-order behav...

    Authors: Joseph D Buxbaum, Catalina Betancur, Ozlem Bozdagi, Nate P Dorr, Gregory A Elder and Patrick R Hof

    Citation: Molecular Autism 2012 3:1

    Content type: Short report

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  30. Duplication of chromosome 15q11-q13 (dup15q) accounts for approximately 3% of autism cases. Chromosome 15q11-q13 contains imprinted genes necessary for normal mammalian neurodevelopment controlled by a differe...

    Authors: Haley A Scoles, Nora Urraca, Samuel W Chadwick, Lawrence T Reiter and Janine M LaSalle

    Citation: Molecular Autism 2011 2:19

    Content type: Research

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  31. Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong genetic component. The skewed prevalence toward males and evidence suggestive of linkage to the X chromosome in some studie...

    Authors: Ren-Hua Chung, Deqiong Ma, Kai Wang, Dale J Hedges, James M Jaworski, John R Gilbert, Michael L Cuccaro, Harry H Wright, Ruth K Abramson, Ioanna Konidari, Patrice L Whitehead, Gerard D Schellenberg, Hakon Hakonarson, Jonathan L Haines, Margaret A Pericak-Vance and Eden R Martin

    Citation: Molecular Autism 2011 2:18

    Content type: Research

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  32. The inheritance pattern in most cases of autism is complex. The risk of autism is increased in siblings of children with autism and previous studies have indicated that the level of risk can be further identif...

    Authors: Jerome Carayol, Gerard D Schellenberg, Beth Dombroski, Emmanuelle Genin, Francis Rousseau and Geraldine Dawson

    Citation: Molecular Autism 2011 2:17

    Content type: Research

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  33. The neurobiological basis of autism remains poorly understood. The diagnosis of autism is based solely on behavioural characteristics because there are currently no reliable biological markers. To test whether...

    Authors: Keiko Iwata, Hideo Matsuzaki, Taishi Miyachi, Chie Shimmura, Shiro Suda, Kenji J Tsuchiya, Kaori Matsumoto, Katsuaki Suzuki, Yasuhide Iwata, Kazuhiko Nakamura, Masatsugu Tsujii, Toshirou Sugiyama, Kohji Sato and Norio Mori

    Citation: Molecular Autism 2011 2:16

    Content type: Short report

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  34. The brain develops in concert and in coordination with the developing facial tissues, with each influencing the development of the other and sharing genetic signaling pathways. Autism spectrum disorders (ASDs)...

    Authors: Kristina Aldridge, Ian D George, Kimberly K Cole, Jordan R Austin, T Nicole Takahashi, Ye Duan and Judith H Miles

    Citation: Molecular Autism 2011 2:15

    Content type: Research

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  35. Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we ex...

    Authors: Shiro Suda, Keiko Iwata, Chie Shimmura, Yosuke Kameno, Ayyappan Anitha, Ismail Thanseem, Kazuhiko Nakamura, Hideo Matsuzaki, Kenji J Tsuchiya, Genichi Sugihara, Yasuhide Iwata, Katsuaki Suzuki, Keita Koizumi, Haruhiro Higashida, Nori Takei and Norio Mori

    Citation: Molecular Autism 2011 2:14

    Content type: Short report

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  36. Immune anomalies have been documented in individuals with autism spectrum disorders (ASDs) and their family members. It is unknown whether the maternal immune profile during pregnancy is associated with the ri...

    Authors: Paula E Goines, Lisa A Croen, Daniel Braunschweig, Cathleen K Yoshida, Judith Grether, Robin Hansen, Martin Kharrazi, Paul Ashwood and Judy Van de Water

    Citation: Molecular Autism 2011 2:13

    Content type: Research

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  37. Stimulus-related γ-band oscillations, which may be related to perceptual binding, are reduced in people with autism spectrum disorders (ASD). The purpose of this study was to examine auditory transient and ste...

    Authors: Donald C Rojas, Peter D Teale, Keeran Maharajh, Eugene Kronberg, Katie Youngpeter, Lisa B Wilson, Alissa Wallace and Susan Hepburn

    Citation: Molecular Autism 2011 2:11

    Content type: Research

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  38. The autism spectrum disorders (ASDs) are complex neurodevelopmental disorders that result in severe and pervasive impairment in the development of reciprocal social interaction and verbal and nonverbal communi...

    Authors: Yuka Yasuda, Ryota Hashimoto, Hidenaga Yamamori, Kazutaka Ohi, Motoyuki Fukumoto, Satomi Umeda-Yano, Ikuko Mohri, Akira Ito, Masako Taniike and Masatoshi Takeda

    Citation: Molecular Autism 2011 2:9

    Content type: Research

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  39. SLC25A12 was previously identified by a linkage-directed association analysis in autism. In this study, we investigated the relationship between three SLC25A12 single nucleotide polymorphisms (SNPs) (rs2056202, r...

    Authors: Soo-Jeong Kim, Raquel M Silva, Cindi G Flores, Suma Jacob, Stephen Guter, Gregory Valcante, Annette M Zaytoun, Edwin H Cook and Judith A Badner

    Citation: Molecular Autism 2011 2:8

    Content type: Research

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  40. The inbred mouse strain BTBR T+ tf/J (BTBR) exhibits behavioral deficits that mimic the core deficits of autism. Neuroanatomically, the BTBR strain is also characterized by a complete absence of the corpus cal...

    Authors: Diane T Stephenson, Sharon M O'Neill, Sapna Narayan, Aadhya Tiwari, Elizabeth Arnold, Harry D Samaroo, Fu Du, Robert H Ring, Brian Campbell, Mathew Pletcher, Vidita A Vaidya and Daniel Morton

    Citation: Molecular Autism 2011 2:7

    Content type: Research

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  41. Fragile X syndrome is caused by loss of function of the fragile X mental retardation 1 (FMR1) gene and shares multiple phenotypes with autism. We have previously found reduced expression of the protein product of...

    Authors: S Hossein Fatemi and Timothy D Folsom

    Citation: Molecular Autism 2011 2:6

    Content type: Research

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  42. Autism is a neurodevelopmental disorder characterized by impairments in social interaction and deficits in verbal and nonverbal communication, together with the presence of repetitive behaviors or a limited re...

    Authors: Sharifia Wills, Christy C Rossi, Jeffrey Bennett, Veronica Martinez-Cerdeño, Paul Ashwood, David G Amaral and Judy Van de Water

    Citation: Molecular Autism 2011 2:5

    Content type: Research

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