American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington: American Psychiatric Association; 2013.
Google Scholar
Hilton CL, Harper JD, Kueker RH, Lang AR, Abbacchi AM, Todorov A, et al. Sensory responsiveness as a predictor of social severity in children with high functioning autism spectrum disorders. J Autism Dev Disord. 2010;40:937–45.
PubMed
Google Scholar
Fournier KA, Hass CJ, Naik SK, Lodha N, Cauraugh JH. Motor coordination in autism spectrum disorders: a synthesis and meta-analysis. J Autism Dev Disord. 2010;40:1227–40.
PubMed
Google Scholar
Brenner LA, Turner KC, Müller R-A. Eye movement and visual search: are there elementary abnormalities in autism? J Autism Dev Disord. 2007;37:1289–309.
PubMed
Google Scholar
Johnson BP, Lum JAG, Rinehart NJ, Fielding J. Ocular motor disturbances in autism spectrum disorders: systematic review and comprehensive meta-analysis. Neurosci Biobehav Rev. 2016;69:260–79.
PubMed
Google Scholar
Karatekin C. Eye tracking studies of normative and atypical development. Dev Rev. 2007;27:283–348.
Google Scholar
Takarae Y. Pursuit eye movement deficits in autism. Brain. 2004;127:2584–94.
PubMed
Google Scholar
Wilkes BJ, Carson TB, Patel KP, Lewis MH, White KD. Oculomotor performance in children with high-functioning autism spectrum disorders. Res Dev Disabil. 2015;38:338–44.
PubMed
Google Scholar
Posner MI, Rothbart MK, Voelker P. Developing brain networks of attention. Curr Opin Pediatr. 2016;28:720–4.
PubMed
PubMed Central
Google Scholar
Chan R, Shum D, Toulopoulou T, Chen E. Assessment of executive functions: review of instruments and identification of critical issues. Arch Clin Neuropsychol. 2008;23:201–16.
PubMed
Google Scholar
Diamond A. Executive functions. Annu Rev Psychol. 2013;64:135–68.
PubMed
Google Scholar
Snyder HR, Miyake A, Hankin BL. Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches. Front Psychol [Internet]. 2015;6:328.
Google Scholar
Craig AB, Brown ER, Upright J, DeRosier ME. Enhancing children’s social emotional functioning through virtual game-based delivery of social skills training. J Child Fam Stud. 2016;25:959–68.
Google Scholar
Hill EL. Executive dysfunction in autism☆. Trends Cogn Sci. 2004;8:26–32.
PubMed
Google Scholar
Keehn B, Müller R-A, Townsend J. Atypical attentional networks and the emergence of autism. Neurosci Biobehav Rev. 2013;37:164–83.
PubMed
Google Scholar
Sacrey L-AR, Armstrong VL, Bryson SE, Zwaigenbaum L. Impairments to visual disengagement in autism spectrum disorder: a review of experimental studies from infancy to adulthood. Neurosci Biobehav Rev. 2014;47:559–77.
PubMed
Google Scholar
Chawarska K, Ye S, Shic F, Chen L. Multilevel differences in spontaneous social attention in toddlers with autism spectrum disorder. Child Dev. 2016;87:543–57.
PubMed
Google Scholar
Elsabbagh M, Volein A, Csibra G, Holmboe K, Garwood H, Tucker L, et al. Neural correlates of eye gaze processing in the infant broader autism phenotype. Biol Psychiatry. 2009;65:31–8.
PubMed
Google Scholar
Jones W, Klin A. Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism. Nature. 2013;504:427–31.
CAS
PubMed
PubMed Central
Google Scholar
Keehn B, Lincoln AJ, Müller R-A, Townsend J. Attentional networks in children and adolescents with autism spectrum disorder. J Child Psychol Psychiatry. 2010;51:1251–9.
PubMed
PubMed Central
Google Scholar
Bedford R, Pickles A, Gliga T, Elsabbagh M, Charman T, Johnson MH. Additive effects of social and non-social attention during infancy relate to later autism spectrum disorder. Dev Sci. 2014;17:612–20.
PubMed
PubMed Central
Google Scholar
Elsabbagh M, Fernandes J, Jane Webb S, Dawson G, Charman T, Johnson MH. Disengagement of visual attention in infancy is associated with emerging autism in toddlerhood. Biol Psychiatry. 2013;74:189–94.
PubMed
PubMed Central
Google Scholar
Landry R, Bryson SE. Impaired disengagement of attention in young children with autism. J Child Psychol Psychiatry. 2004;45:1115–22.
PubMed
Google Scholar
Mosconi MW, Kay M, D’Cruz A-M, Seidenfeld A, Guter S, Stanford LD, et al. Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders. Psychol Med. 2009;39:1559–66.
CAS
PubMed
PubMed Central
Google Scholar
Reulen J. Latency of visually evoked saccadic eye-movements. 1. Saccadic latency and the facilitation model. Biol Cybern. 1984;50:251–62.
CAS
PubMed
Google Scholar
Reuter-Lorenz PA, Hughes HC, Fendrich R. The reduction of saccadic latency by prior offset of the fixation point: an analysis of the gap effect. Percept Psychophys. 1991;49:167–75.
CAS
PubMed
Google Scholar
Saslow MG. Latency for saccadic eye movement*. J Opt Soc Am. 1967;57:1030–3.
CAS
PubMed
Google Scholar
Reulen J. Latency of visually evoked saccadic eye-movements. 2. Temporal properties of the facilitation mechanism. Biol Cybern. 1984;50:263–71.
CAS
PubMed
Google Scholar
Rommelse NNJ, Altink ME, Arias-Vásquez A, Buschgens CJM, Fliers E, Faraone SV, et al. A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1536–46.
CAS
PubMed
Google Scholar
Bellocchi S, Henry V, Baghdadli A. Visual attention processes and oculomotor control in autism spectrum disorder: a brief review and future directions. J Cogn Educ Psychol. 2017;16:77–93.
Google Scholar
Luna B, Garver KE, Urban TA, Lazar NA, Sweeney JA. Maturation of cognitive processes from late childhood to adulthood. Child Dev. 2004;75:1357–72.
PubMed
Google Scholar
Loe IM, Lee ES, Luna B, Feldman HM. Executive function skills are associated with reading and parent-rated child function in children born prematurely. Early Hum Dev. 2012;88:111–8.
PubMed
Google Scholar
Klein C, Foerster F. Development of prosaccade and antisaccade task performance in participants aged 6 to 26 years. Psychophysiology. 2001;38:179–89.
CAS
PubMed
Google Scholar
Schmitt LM, Cook EH, Sweeney JA, Mosconi MW. Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in cerebellum and brainstem. Mol Autism. 2014;5:47.
PubMed
PubMed Central
Google Scholar
Todd J, Mills C, Wilson AD, Plumb MS, Mon-Williams MA. Slow motor responses to visual stimuli of low salience in autism. J Motor Behav. 2009;41:419–26.
Google Scholar
Johnson BP, Rinehart NJ, Papadopoulos N, Tonge B, Millist L, White O, et al. A closer look at visually guided saccades in autism and Asperger’s disorder. Front Integr Neurosci. 2012;6:99.
PubMed
PubMed Central
Google Scholar
Sweeney J, Takarae Y, Macmillan C, Luna B, Minshew N. Eye movements in neurodevelopmental disorders. Curr Opin Neurol. 2004;17:37–42.
PubMed
Google Scholar
Johnson BP, Rinehart NJ, White O, Millist L, Fielding J. Saccade adaptation in autism and Asperger’s disorder. Neuroscience. 2013;243:76–87.
CAS
PubMed
Google Scholar
Mosconi MW, Luna B, Kay-Stacey M, Nowinski CV, Rubin LH, Scudder C, et al. Saccade adaptation abnormalities implicate dysfunction of cerebellar-dependent learning mechanisms in autism spectrum disorders (ASD). PLoS ONE. 2013;8:e63709.
CAS
PubMed
PubMed Central
Google Scholar
Kawakubo Y, Kasai K, Okazaki S, Hosokawa-Kakurai M, Watanabe K, Kuwabara H, et al. Electrophysiological abnormalities of spatial attention in adults with autism during the gap overlap task. Clin Neurophysiol. 2007;118:1464–71.
PubMed
Google Scholar
Bjorklund DF, Harnishfeger KK. The resources construct in cognitive development: diverse sources of evidence and a theory of inefficient inhibition. Dev Rev. 1990;10:48–71.
Google Scholar
Dempster FN. The rise and fall of the inhibitory mechanism: toward a unified theory of cognitive development and aging. Dev Rev. 1992;12:45–75.
Google Scholar
Geurts HM, van den Bergh SFWM, Ruzzano L. Prepotent response inhibition and interference control in autism spectrum disorders: two meta-analyses. Autism Res. 2014;7:407–20.
PubMed
Google Scholar
Hutton SB. Cognitive control of saccadic eye movements. Brain Cognit. 2008;68:327–40.
CAS
Google Scholar
Agam Y, Joseph RM, Barton JJS, Manoach DS. Reduced cognitive control of response inhibition by the anterior cingulate cortex in autism spectrum disorders. Neuroimage. 2010;52:336–47.
PubMed
Google Scholar
Langen M, Leemans A, Johnston P, Ecker C, Daly E, Murphy CM, et al. Fronto-striatal circuitry and inhibitory control in autism: findings from diffusion tensor imaging tractography. Cortex. 2012;48:183–93.
PubMed
Google Scholar
Faja S, Darling LN. Variation in restricted and repetitive behaviors and interests relates to inhibitory control and shifting in children with autism spectrum disorder. Autism. 2019;23:1262–72.
PubMed
Google Scholar
Sanderson C, Allen ML. The specificity of inhibitory impairments in autism and their relation to ADHD-type symptoms. J Autism Dev Disord. 2013;43:1065–79.
PubMed
Google Scholar
Schmitt LM, White SP, Cook EH, Sweeney JA, Mosconi MW. Cognitive mechanisms of inhibitory control deficits in autism spectrum disorder. J Child Psychol Psychiatry. 2018;59:586–95.
PubMed
Google Scholar
Voorhies W, Dajani DR, Vij SG, Shankar S, Turan TO, Uddin LQ. Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder. Autism Res. 2018;11:1468–78.
PubMed
Google Scholar
St. John T, Estes AM, Dager SR, Kostopoulos P, Wolff JJ, Pandey J, et al. Emerging executive functioning and motor development in infants at high and low risk for autism spectrum disorder. Front Psychol. 2016;7:1016.
PubMed
PubMed Central
Google Scholar
Goldberg MC, Lasker AG, Zee DS, Garth E, Tien A, Landa RJ. Deficits in the initiation of eye movements in the absence of a visual target in adolescents with high functioning autism. Neuropsychologia. 2002;40:2039–49.
CAS
PubMed
Google Scholar
Kelly DJ, Walker R, Norbury CF. Deficits in volitional oculomotor control align with language status in autism spectrum disorders. Dev Sci. 2013;16:56–66.
PubMed
Google Scholar
Manoach DS. Deficient saccadic inhibition in Asperger’s disorder and the social-emotional processing disorder. J Neurol Neurosurg Psychiatry. 2004;75:1719–26.
CAS
PubMed
PubMed Central
Google Scholar
Luna B, Doll SK, Hegedus SJ, Minshew NJ, Sweeney JA. Maturation of executive function in autism. Biol Psychiatry. 2007;61:474–81.
PubMed
Google Scholar
Padmanabhan A, Garver K, O’Hearn K, Nawarawong N, Liu R, Minshew N, et al. Developmental changes in brain function underlying inhibitory control in autism spectrum disorders. Autism Res. 2015;8:123–35.
PubMed
Google Scholar
Nurnberger JI, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, et al. Diagnostic interview for genetic studies: rationale, unique features, and training. Arch Gen Psychiatry. 1994;51:849–59.
PubMed
Google Scholar
Orvaschel H, Puig-antich J, Chambers W, Tabrizi MA, Johnson R. Retrospective assessment of prepubertal major depression with the kiddie-SADS-E. J Am Acad Child Psychiatry. 1982;21:392–7.
CAS
PubMed
Google Scholar
Rutter M, LeCouteur A, Lord C. (ADITM-R) Autism diagnostic interview-revised. Los Angeles: Western Psychological Services; 2003.
Google Scholar
Lord C, Risi S, Lambrecht L, Cook EH, Leventhal BL, DiLavore PC, et al. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000;30:205–23.
CAS
PubMed
Google Scholar
Wechsler D. WISC-IV. Echelle d’intelligence de Wechsler pour enfants – 4ème édition. Manuel d’interprétation. 4th ed. Paris: ECPA; 2006.
Wechsler D. Wechsler adult intelligence scale fourth UK edition (WIAS‐IV) administration and scoring manual. London; 2008.
Gioia GA, Isquith PK, Retzlaff PD, Espy KA. Confirmatory factor analysis of the behavior rating inventory of executive function (BRIEF) in a clinical sample. Child Neuropsychol. 2002;8:249–57.
PubMed
Google Scholar
Orvaschel H, Puig-Antich J. Schedule for affective disorders and schizophrenia for school-age children: epidemiologic version. Fort Lauderdale: Nova University; 1987.
Google Scholar
Zalla T, Fernandez LG, Pieron M, Seassau M, Leboyer M. Reduced saccadic inhibition of return to moving eyes in autism spectrum disorders. Vis Res. 2016;127:115–21.
PubMed
Google Scholar
Fischer B, Breitmeyer B. Mechanisms of visual attention revealed by saccadic eye movements. Neuropsychologia. 1987;25:73–83.
CAS
PubMed
Google Scholar
Fischer B, Weber H. Express saccades and visual attention. Behav Brain Sci. 1993;16:553–67.
Google Scholar
Cousijn J, Hessels RS, der Stigchel SV, Kemner C. Evaluation of the psychometric properties of the gap-overlap task in 10-month-old infants. Infancy. 2017;22:571–9.
Google Scholar
Van der Stigchel S, Hessels RS, van Elst JC, Kemner C. The disengagement of visual attention in the gap paradigm across adolescence. Exp Brain Res. 2017;235:3585–92.
PubMed
PubMed Central
Google Scholar
Munoz DP, Everling S. Look away: the anti-saccade task and the voluntary control of eye movement. Nat Rev Neurosci. 2004;5:218–28.
CAS
PubMed
Google Scholar
Thakkar KN, Polli FE, Joseph RM, Tuch DS, Hadjikhani N, Barton JJS, et al. Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD). Brain. 2008;131:2464–78.
PubMed
PubMed Central
Google Scholar
Olk B, Kingstone A. Why are antisaccades slower than prosaccades? A novel finding using a new paradigm. NeuroReport. 2003;14:151–5.
PubMed
Google Scholar
Aron AR. From reactive to proactive and selective control: developing a richer model for stopping inappropriate responses. Biol Psychiatry. 2011;69:e55-68.
PubMed
Google Scholar
Gaetano J. Holm-Bonferroni Sequential Correction: An EXCEL Calculator - Ver. 1.2. 2013.
Ozyurt J, Greenlee MW. Neural correlates of inter- and intra-individual saccadic reaction time differences in the gap/overlap paradigm. J Neurophysiol. 2011;105:2438–47.
PubMed
Google Scholar
Chan JL, Kucyi A. What can fMRI tell us about functional variability in the oculomotor system and saccade performance? J Neurophysiol. 2012;107:2295–7.
PubMed
Google Scholar
Northoff G, Qin P, Nakao T. Rest-stimulus interaction in the brain: a review. TINS. 2010;33:277–84.
CAS
PubMed
Google Scholar
Luna B, Velanova K, Geier CF. Development of eye-movement control. Brain Cognit. 2008;68:293–308.
Google Scholar
Klein C, Foerster F, Hartnegg K, Fischer B. Lifespan development of pro- and anti-saccades: multiple regression models for point estimates. Dev Brain Res. 2005;160:113–23.
CAS
Google Scholar
Bucci MP, Seassau M. Saccadic eye movements in children: a developmental study. Exp Brain Res. 2012;222:21–30.
PubMed
Google Scholar
Irving EL, Tajik-Parvinchi DJ, Lillakas L, González EG, Steinbach MJ. Mixed pro and antisaccade performance in children and adults. Brain Res. 2009;1255:67–74.
CAS
PubMed
Google Scholar
Munoz DP, Broughton JR, Goldring JE, Armstrong IT. Age-related performance of human subjects on saccadic eye movement tasks. Exp Brain Res. 1998;121:391–400.
CAS
PubMed
Google Scholar
Minshew NJ, Keller TA. The nature of brain dysfunction in autism: functional brain imaging studies. Curr Opin Neurol. 2010;23:124–30.
PubMed
PubMed Central
Google Scholar
Landry O, Parker A. A meta-analysis of visual orienting in autism. Front Hum Neurosci. 2013;7:1–12.
Google Scholar
Robertson CE, Kravitz DJ, Freyberg J, Baron-Cohen S, Baker CI. Tunnel vision: sharper gradient of spatial attention in autism. J Neurosci. 2013;33:6776–81.
CAS
PubMed
PubMed Central
Google Scholar
Ronconi L, Gori S, Ruffino M, Franceschini S, Urbani B, Molteni M, et al. Decreased coherent motion discrimination in autism spectrum disorder: the role of attentional zoom-out deficit. PLoS ONE. 2012;7:e49019.
CAS
PubMed
PubMed Central
Google Scholar
Ronconi L, Gori S, Giora E, Ruffino M, Molteni M, Facoetti A. Deeper attentional masking by lateral objects in children with autism. Brain Cognit. 2013;82:213–8.
Google Scholar
van der Geest JN, Kemner C, Camfferman G, Verbaten MN, van Engeland H. Eye movements, visual attention, and autism: a saccadic reaction time study using the gap and overlap paradigm. Biol Psychiatry. 2001;50:614–9.
PubMed
Google Scholar
Kikuchi Y, Senju A, Akechi H, Tojo Y, Osanai H, Hasegawa T. Atypical disengagement from faces and its modulation by the control of eye fixation in children with autism spectrum disorder. J Autism Dev Disord. 2011;41:629–45.
PubMed
PubMed Central
Google Scholar
Elsabbagh M, Volein A, Holmboe K, Tucker L, Csibra G, Baron-Cohen S, et al. Visual orienting in the early broader autism phenotype: disengagement and facilitation. J Child Psychol Psychiatry. 2009;50:637–42.
PubMed
PubMed Central
Google Scholar
Fischer J, Koldewyn K, Jiang YV, Kanwisher N. Unimpaired attentional disengagement and social orienting in children with autism. Clin Psychol Sci. 2014;2:214–23.
PubMed
PubMed Central
Google Scholar
Kawakubo Y, Maekawa H, Itoh K, Hashimoto O, Iwanami A. Spatial attention in individuals with pervasive developmental disorders using the gap overlap task. Psychiatry Res. 2004;125:269–75.
PubMed
Google Scholar
Leekam SR, López B, Moore C. Attention and joint attention in preschool children with autism. Dev Psychol. 2000;36:261–73.
CAS
PubMed
Google Scholar
Sabatos-DeVito M, Schipul SE, Bulluck JC, Belger A, Baranek GT. Eye tracking reveals impaired attentional disengagement associated with sensory response patterns in children with autism. J Autism Dev Disord. 2016;46:1319–33.
PubMed
PubMed Central
Google Scholar
Fischer B, Biscaldi M, Gezeck S. On the development of voluntary and reflexive components in human saccade generation. Brain Res. 1997;754:285–97.
CAS
PubMed
Google Scholar
Vaidya CJ, You X, Mostofsky S, Pereira F, Berl MM, Kenworthy L. Data-driven identification of subtypes of executive function across typical development, attention deficit hyperactivity disorder, and autism spectrum disorders. J Child Psychol Psychiatry. 2020;61:51–61.
PubMed
Google Scholar
Happé F, Booth R, Charlton R, Hughes C. Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. Brain Cognit. 2006;61:25–39.
Google Scholar
Minshew NJ, Luna B, Sweeney JA. Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism. Neurology. 1999;52:917–22.
CAS
PubMed
Google Scholar
Muggleton NG, Chen C-Y, Tzeng OJL, Hung DL, Juan C-H. Inhibitory control and the frontal eye fields. J Cogn Neurosci. 2010;22:2804–12.
PubMed
Google Scholar
Kenet T, Orekhova EV, Bharadwaj H, Shetty NR, Israeli E, Lee AKC, et al. Disconnectivity of the cortical ocular motor control network in autism spectrum disorders. Neuroimage. 2012;61:1226–34.
PubMed
Google Scholar
Brown MRG, Vilis T, Everling S. Frontoparietal activation with preparation for antisaccades. J Neurophysiol. 2007;98:1751–62.
PubMed
Google Scholar
Ettinger U, Ffytche DH, Kumari V, Kathmann N, Reuter B, Zelaya F, et al. Decomposing the neural correlates of antisaccade eye movements using event-related fMRI. Cereb Cortex. 2008;18:1148–59.
PubMed
Google Scholar
Jamadar SD, Fielding J, Egan GF. Quantitative meta-analysis of fMRI and PET studies reveals consistent activation in fronto-striatal-parietal regions and cerebellum during antisaccades and prosaccades. Front Psychol. 2013;4:749.
PubMed
PubMed Central
Google Scholar
Johnston K, Levin HM, Koval MJ, Everling S. Top-down control-signal dynamics in anterior cingulate and prefrontal cortex neurons following task switching. Neuron. 2007;53:453–62.
CAS
PubMed
Google Scholar
Minshew NJ, Goldstein G, Siegel DJ. Neuropsychologic functioning in autism: profile of a complex information processing disorder. J Int Neuropsychol Soc. 1997;3:303–16.
CAS
PubMed
Google Scholar