Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children

Table 3 Effects of total sensory features on brainstem FWE-FA in autistic and non-autistic children

Brainstem white matter region	Total sensory features main effect				Group x total sensory features interaction effect
Brainstem white matter region	b	Std Error	t	p	b	Std Error	t	p
CST	0.002	0.011	0.13	.89	0.009	0.023	0.38	.71
ML	− 0.008	0.008	− 1.02	.31	0.042	0.016	2.56	.01^a
LL	− 0.005	0.013	− 0.36	.72	0.056	0.027	2.07	.04^a
FPT	− 0.016	0.012	− 1.30	.19	0.023	0.026	0.91	.37
POTPT	− 0.013	0.009	− 1.38	.17	0.028	0.019	1.48	.14
STT	0.001	0.009	0.14	.89	0.011	0.018	0.63	.53
SCPCT	− 0.001	0.006	− 0.09	.93	0.015	0.013	1.12	.26
SCPSC	− 0.012	0.010	− 1.19	.23	0.015	0.021	0.74	.46
ICPMC	0.000	0.009	0.05	.96	0.023	0.019	1.18	.24
ICPVC	0.006	0.010	0.55	.58	0.019	0.021	0.91	.36
MCP	0.013	0.008	1.62	.11	0.026	0.017	1.55	.12

Main and interaction effects controlling for age, sex and average head motion during DWI brain scan
ML medial lemniscus; LL lateral lemniscus; STT spinothalamic tract; SCPCT superior cerebellar peduncle cerebellothalamic tract; SCPSC superior cerebellar peduncle spinocerebellar tract; MCP Middle cerebellar peduncle, ICPMC Inferior cerebellar peduncle tracts from medulla oblongata to the cerebellum, ICPVCT Inferior cerebellar peduncle vestibulocerebellar tract, FPT Frontopontine tract, POTPT Parieto-occipito-temporo-pontine tract, CST Corticospinal tract
^aUncorrected p < .05
^bFalse discovery rate (FDR) corrected p < .05

ISSN: 2040-2392