Christensen DL, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years--autism and developmental disabilities monitoring network, 11 sites, United States, 2012. MMWR Surveill Summ. 2016;65(3):1–23.
Article
PubMed
PubMed Central
Google Scholar
IAAC. In: I.A.C.C. (IACC), editor. 2016–2017 Interagency Autism Coordinating Committee Strategic Plan For Autism Spectrum Disorder; 2017. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website: https://iacc.hhs.gov/publications/strategic-plan/2017/. Accessed 23 Dec 2018.
Hsiao EY. Gastrointestinal issues in autism spectrum disorder. Harv Rev Psychiatry. 2014;22(2):104–11.
Article
PubMed
Google Scholar
Chaidez V, Hansen RL, Hertz-Picciotto I. Gastrointestinal problems in children with autism, developmental delays or typical development. J Autism Dev Disord. 2014;44(5):1117–27.
Article
PubMed
PubMed Central
Google Scholar
Kuhlthau KA, et al. Associations of quality of life with health-related characteristics among children with autism. Autism. 2018;22(7):804-813.
Bresnahan M, et al. Association of maternal report of infant and toddler gastrointestinal symptoms with autism: evidence from a prospective birth cohort. JAMA Psychiatry. 2015;72(5):466–74.
Article
PubMed
PubMed Central
Google Scholar
Grubisic V, et al. Pitt-Hopkins mouse model has altered particular gastrointestinal transits in vivo. Autism Res. 2015;8(5):629–33.
Article
PubMed
PubMed Central
Google Scholar
Bernier R, et al. Disruptive CHD8 mutations define a subtype of autism early in development. Cell. 2014;158(2):263–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Betancur C, Buxbaum JD. SHANK3 haploinsufficiency: a "common" but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders. Mol Autism. 2013;4(1):17.
Article
CAS
PubMed
PubMed Central
Google Scholar
Phelan K, McDermid HE. The 22q13.3 deletion syndrome (Phelan-McDermid syndrome). Mol Syndromol. 2012;2(3–5):186–201.
CAS
PubMed
Google Scholar
Soorya L, et al. Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency. Mol Autism. 2013;4(1):18.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sarasua SM, et al. Clinical and genomic evaluation of 201 patients with Phelan-McDermid syndrome. Hum Genet. 2014;133(7):847–59.
Article
CAS
PubMed
Google Scholar
Jiang YH, Ehlers MD. Modeling autism by SHANK gene mutations in mice. Neuron. 2013;78(1):8–27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mei Y, et al. Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature. 2016;530(7591):481–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Peixoto RT, et al. Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(−/−) mice. Nat Neurosci. 2016;19(5):716–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bozdagi O, et al. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism. 2010;1(1):15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Roussignol G, et al. Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. J Neurosci. 2005;25(14):3560–70.
Article
CAS
PubMed
PubMed Central
Google Scholar
Peca J, et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011;472(7344):437–42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bockers TM, et al. Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin. J Biol Chem. 2001;276(43):40104–12.
Article
CAS
PubMed
Google Scholar
Kozol RA, et al. Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis. Hum Mol Genet. 2015;24(14):4006–23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu CX, et al. Developmental profiling of ASD-related shank3 transcripts and their differential regulation by valproic acid in zebrafish. Dev Genes Evol. 2016;226(6):389–400.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huett A, et al. The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Exp Cell Res. 2009;315(12):2001–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chaudhury A. Molecular handoffs in nitrergic neurotransmission. Front Med (Lausanne). 2014;1:8.
Google Scholar
Raab M, Boeckers TM, Neuhuber WL. Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system. Neuroscience. 2010;171(2):421–33.
Article
CAS
PubMed
Google Scholar
Qin L, et al. Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nat Neurosci. 2018;21(4):564–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Grabrucker AM. A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders. Dev Neurobiol. 2014;74(2):136–46.
Article
CAS
PubMed
Google Scholar
Grabrucker S, et al. Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain. 2014;137(Pt 1):137–52.
Article
PubMed
Google Scholar
Pfaender S, et al. Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3. Sci Rep. 2017;7:45190.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wei SC, et al. SHANK3 regulates intestinal barrier function through modulating ZO-1 expression through the PKCepsilon-dependent pathway. Inflamm Bowel Dis. 2017;23(10):1730–40.
Article
PubMed
Google Scholar
Abrams AJ, et al. Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder. Nat Genet. 2015;47(8):926–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ijaz S, Hoffman EJ. Zebrafish: a translational model system for studying neuropsychiatric disorders. J Am Acad Child Adolesc Psychiatry. 2016;55(9):746–8.
Article
PubMed
PubMed Central
Google Scholar
Kozol RA, et al. Function over form: modeling groups of inherited neurological conditions in zebrafish. Front Mol Neurosci. 2016;9:55.
Article
PubMed
PubMed Central
CAS
Google Scholar
Baraban SC, Dinday MT, Hortopan GA. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410.
Article
PubMed
Google Scholar
Hoffman EJ, et al. Estrogens suppress a behavioral phenotype in zebrafish mutants of the autism risk gene, CNTNAP2. Neuron. 2016;89(4):725–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
White R, Rose K, Zon L. Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013;13(9):624–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shepherd I, Eisen J. Development of the zebrafish enteric nervous system. Methods Cell Biol. 2011;101:143–60.
Article
PubMed
PubMed Central
Google Scholar
Chen YC, et al. Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells. PLoS One. 2012;7(4):e34408.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rich A, et al. Kit signaling is required for development of coordinated motility patterns in zebrafish gastrointestinal tract. Zebrafish. 2013;10(2):154–60.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jordi J, et al. A high-throughput assay for quantifying appetite and digestive dynamics. Am J Phys Regul Integr Comp Phys. 2015;309(4):R345–57.
CAS
Google Scholar
Zhao X, Pack M. Modeling intestinal disorders using zebrafish. Methods Cell Biol. 2017;138:241–70.
Article
CAS
PubMed
Google Scholar
Holmberg A, et al. Ontogeny of the gut motility control system in zebrafish Danio rerio embryos and larvae. J Exp Biol. 2004;207(Pt 23):4085–94.
Article
PubMed
Google Scholar
Olsson C, Holmberg A, Holmgren S. Development of enteric and vagal innervation of the zebrafish (Danio rerio) gut. J Comp Neurol. 2008;508(5):756–70.
Article
PubMed
Google Scholar
Holmberg A, Olsson C, Holmgren S. The effects of endogenous and exogenous nitric oxide on gut motility in zebrafish Danio rerio embryos and larvae. J Exp Biol. 2006;209(Pt 13):2472–9.
Article
CAS
PubMed
Google Scholar
Wallace KN, et al. Intestinal growth and differentiation in zebrafish. Mech Dev. 2005;122(2):157–73.
Article
CAS
PubMed
Google Scholar
Wallace KN, Pack M. Unique and conserved aspects of gut development in zebrafish. Dev Biol. 2003;255(1):12–29.
Article
CAS
PubMed
Google Scholar
Ganz J, Melancon E, Eisen JS. Zebrafish as a model for understanding enteric nervous system interactions in the developing intestinal tract. Methods Cell Biol. 2016;134:139–64.
Article
CAS
PubMed
Google Scholar
Yanez J, et al. Gustatory and general visceral centers and their connections in the brain of adult zebrafish: a carbocyanine dye tract-tracing study. J Comp Neurol. 2017;525(2):333–62.
Article
CAS
PubMed
Google Scholar
Jiang Q, et al. Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. Am J Hum Genet. 2015;96(4):581–96.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bonora E, et al. Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction. Gastroenterology. 2015;148(4):771–782.e11.
Article
CAS
PubMed
Google Scholar
Glasauer SM, Neuhauss SC. Whole-genome duplication in teleost fishes and its evolutionary consequences. Mol Gen Genomics. 2014;289(6):1045–60.
Article
CAS
Google Scholar
Bayes A, et al. Evolution of complexity in the zebrafish synapse proteome. Nat Commun. 2017;8:14613.
Article
PubMed
PubMed Central
Google Scholar
Hurley IA, et al. A new time-scale for ray-finned fish evolution. Proc Biol Sci. 2007;274(1609):489–98.
Article
CAS
PubMed
Google Scholar
Leblond CS, et al. Meta-analysis of SHANK mutations in autism spectrum disorders: a gradient of severity in cognitive impairments. PLoS Genet. 2014;10(9):e1004580.
Article
PubMed
PubMed Central
CAS
Google Scholar
Hsieh JY, et al. Rapid development of Purkinje cell excitability, functional cerebellar circuit, and afferent sensory input to cerebellum in zebrafish. Front Neural Circuits. 2014;8:147.
Article
PubMed
PubMed Central
Google Scholar
Satou C, Kimura Y, Higashijima S. Generation of multiple classes of V0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity. J Neurosci. 2012;32(5):1771–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
Montague TG, et al. CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing. Nucleic Acids Res. 2014;42(Web Server issue):W401–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hwang WY, et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol. 2013;31(3):227–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ganser LR, et al. Distinct phenotypes in zebrafish models of human startle disease. Neurobiol Dis. 2013;60:139–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Field HA, et al. Analysis of gastrointestinal physiology using a novel intestinal transit assay in zebrafish. Neurogastroenterol Motil. 2009;21(3):304–12.
Article
CAS
PubMed
Google Scholar
Uyttebroek L, et al. Neurochemical coding of enteric neurons in adult and embryonic zebrafish (Danio rerio). J Comp Neurol. 2010;518(21):4419–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Simonson LW, et al. Characterization of enteric neurons in wild-type and mutant zebrafish using semi-automated cell counting and co-expression analysis. Zebrafish. 2013;10(2):147–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang X, et al. Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice. Mol Autism. 2014;5:30.
Article
CAS
PubMed
PubMed Central
Google Scholar
De Rubeis S, Siper PM, Durkin A, Weissman J, Muratet F, Halpern D, MdP T, Frank Y, Lozano R, Wang AT, Holder JL Jr, Betancur C, Buxbaum JD, Kolevzon A. Delineation of the genetic and clinical spectrum of Phelan-McDermid syndrome caused by SHANK3 point mutations. Mol Autism. 2018;9:31-51.
Tu JC, et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999;23(3):583–92.
Article
CAS
PubMed
Google Scholar
Ng AN, et al. Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Dev Biol. 2005;286(1):114–35.
Article
CAS
PubMed
Google Scholar
Linan-Rico A, et al. Mechanosensory signaling in enterochromaffin cells and 5-HT release: potential implications for gut inflammation. Front Neurosci. 2016;10:564.
Article
PubMed
PubMed Central
Google Scholar
Holtmann G, Talley NJ. The stomach-brain axis. Best Pract Res Clin Gastroenterol. 2014;28(6):967–79.
Article
CAS
PubMed
Google Scholar
Groneberg D, Voussen B, Friebe A. Integrative control of gastrointestinal motility by nitric oxide. Curr Med Chem. 2016;23(24):2715–35.
Article
CAS
PubMed
Google Scholar
Grundy D, et al. Fundamentals of neurogastroenterology: basic science. Gastroenterology. 2006;130(5):1391–411.
Article
CAS
PubMed
Google Scholar
Holmberg A, Olsson C, Hennig GW. TTX-sensitive and TTX-insensitive control of spontaneous gut motility in the developing zebrafish (Danio rerio) larvae. J Exp Biol. 2007;210(Pt 6):1084–91.
Article
CAS
PubMed
Google Scholar
Browning KN. Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology. Front Neurosci. 2015;9:413.
Article
PubMed
PubMed Central
Google Scholar
Bellono NW, et al. Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways. Cell. 2017;170(1):185–198.e16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Uyttebroek L, et al. The zebrafish mutant lessen: an experimental model for congenital enteric neuropathies. Neurogastroenterol Motil. 2016;28(3):345–57.
Article
CAS
PubMed
Google Scholar
Wiles TJ, et al. Host gut motility promotes competitive exclusion within a model intestinal microbiota. PLoS Biol. 2016;14(7):e1002517.
Article
PubMed
PubMed Central
CAS
Google Scholar
Parracho HM, et al. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol. 2005;54(Pt 10):987–91.
Article
PubMed
Google Scholar
Yano JM, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;161(2):264–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Waga C, et al. Identification of two novel Shank3 transcripts in the developing mouse neocortex. J Neurochem. 2014;128(2):280–93.
Article
CAS
PubMed
Google Scholar
Qualmann B, et al. Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. J Neurosci. 2004;24(10):2481–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cloney K, et al. Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome. FEBS J. 2018;285(11):2125-2140.
Hyatt TM, Ekker SC. Vectors and techniques for ectopic gene expression in zebrafish. Methods Cell Biol. 1999;59:117–26.
Article
CAS
PubMed
Google Scholar
Samsam M, Ahangari R, Naser SA. Pathophysiology of autism spectrum disorders: revisiting gastrointestinal involvement and immune imbalance. World J Gastroenterol. 2014;20(29):9942–51.
Article
PubMed
PubMed Central
CAS
Google Scholar
de Magistris L, et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr. 2010;51(4):418–24.
Article
PubMed
Google Scholar
Gershon MD, Drakontides AB, Ross LL. Serotonin: synthesis and release from the myenteric plexus of the mouse intestine. Science. 1965;149(3680):197–9.
Article
CAS
PubMed
Google Scholar
Sikander A, Rana SV, Prasad KK. Role of serotonin in gastrointestinal motility and irritable bowel syndrome. Clin Chim Acta. 2009;403(1–2):47–55.
Article
CAS
PubMed
Google Scholar
Crosnier C, et al. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development. 2005;132(5):1093–104.
Article
CAS
PubMed
Google Scholar
Troll JV, et al. Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling. Development. 2018;145(4). https://doi.org/10.1242/dev.155317.
Roach G, et al. Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility. Dev Biol. 2013;376(2):171–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rolig AS, et al. The enteric nervous system promotes intestinal health by constraining microbiota composition. PLoS Biol. 2017;15(2):e2000689.
Article
PubMed
PubMed Central
CAS
Google Scholar
Brugman S. The zebrafish as a model to study intestinal inflammation. Dev Comp Immunol. 2016;64:82–92.
Article
CAS
PubMed
Google Scholar
Ashwood P, et al. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. J Clin Immunol. 2003;23(6):504–17.
Article
PubMed
Google Scholar