Fig. 4

Quality assessment results for each domain of RoB2. ^†Green plus = Low risk of bias, Yellow minus = Some concerns in risk of bias, Red cross = High risk of bias. ^‡D1 = Bias arising from the randomization process, D2 = bias due to deviations from intended interventions, D3 = bias due to missing outcome data, D4 = bias in the measurement of the outcome, D5 = bias in the selection of the reported result