Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder

Table 6 Brain-behavior correlations for free-water in basal ganglia and cerebellar white matter tracts

Tract free-water	ADI-R section C		RBS-R total		RBS-R stereotyped		RBS-R self-injury		RBS-R compulsive		RBS-R ritual		RBS-R sameness		RBS-R restricted interests		SCQ
Tract free-water	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR
DLPFC to Caudate (L)	0.737	0.886	0.012	0.122	0.204	0.408	0.459	0.995	0.066	0.461	0.010	0.096	0.119	0.694	0.003	*0.021	0.001	**0.006
DLPFC to Caudate (R)	0.724	0.886	0.045	0.150	0.096	0.321	0.835	0.995	0.185	0.462	0.045	0.204	0.139	0.694	0.004	*0.021	0.005	*0.013
M1U to Putamen (L)	0.886	0.886	0.887	0.907	0.960	0.960	0.963	0.995	0.637	0.909	0.569	0.773	0.888	0.947	0.917	0.917	0.222	0.370
M1U to Putamen (R)	0.773	0.886	0.780	0.907	0.690	0.767	0.597	0.995	0.781	0.909	0.841	0.841	0.947	0.947	0.903	0.917	0.386	0.531
SCP to M1U (L)	0.208	0.886	0.907	0.907	0.398	0.569	0.581	0.995	0.835	0.909	0.812	0.841	0.664	0.947	0.687	0.858	0.502	0.558
SCP to M1U (R)	0.156	0.886	0.815	0.907	0.505	0.631	0.431	0.995	0.424	0.848	0.619	0.773	0.502	0.947	0.580	0.829	0.787	0.787
SN to Putamen (L)	0.807	0.886	0.035	0.150	0.082	0.321	0.735	0.995	0.138	0.461	0.061	0.204	0.334	0.834	0.025	0.082	0.001	**0.006
SN to Putamen (R)	0.504	0.886	0.289	0.578	0.171	0.408	0.995	0.995	0.618	0.909	0.283	0.567	0.754	0.947	0.128	0.257	0.054	0.108
GPe to STN (L)	0.668	0.886	0.070	0.174	0.041	0.321	0.783	0.995	0.127	0.461	0.204	0.510	0.291	0.834	0.105	0.257	0.004	*0.013
GPe to STN (R)	0.432	0.886	0.516	0.860	0.396	0.569	0.689	0.995	0.909	0.909	0.592	0.773	0.910	0.947	0.336	0.560	0.425	0.531

Raw and FDR corrected p values from Spearman correlations between free-water in basal ganglia and cerebellar tracts and behavioral measures. Measures of RRB included Section C of the Autism Diagnostic Interview-Revised (ADI-R), as well Repetitive Behavior Scale-Revised (RBS-R) total score and subsection scores. The Social Communication Questionnaire (SCQ) measures social and communication behaviors. Significant FDR corrected p values are bolded and indicated by *p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 2040-2392