Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder

Table 3 Fractional anisotropy (free-water corrected) in basal ganglia and cerebellar white matter tracts

Tract FA_T	Mean ± Stdev		Diagnosis		Sex		Diagnosis * sex
Tract FA_T	ASD	TD	p_raw	p_FDR	p_raw	p_FDR	p_raw	p_FDR
DLPFC to Caudate (L)	0.441 ± 0.014	0.450 ± 0.017	0.001	*0.008	0.069	0.114	0.772	0.956
DLPFC to Caudate (R)	0.409 ± 0.017	0.415 ± 0.017	0.014	0.063	0.032	0.063	0.255	0.956
M1U to Putamen (L)	0.403 ± 0.016	0.406 ± 0.020	0.290	0.322	0.527	0.585	0.675	0.956
M1U to Putamen (R)	0.399 ± 0.017	0.401 ± 0.022	0.367	0.367	0.810	0.810	0.313	0.956
SCP to M1U (L)	0.534 ± 0.014	0.537 ± 0.016	0.251	0.314	0.273	0.363	0.694	0.956
SCP to M1U (R)	0.520 ± 0.015	0.524 ± 0.019	0.082	0.165	0.290	0.363	0.956	0.956
SN to Putamen (L)	0.417 ± 0.016	0.422 ± 0.018	0.108	0.181	0.001	**0.004	0.480	0.956
SN to Putamen (R)	0.405 ± 0.017	0.409 ± 0.020	0.152	0.218	< 0.001	***< 0.001	0.371	0.956
GPe to STN (L)	0.558 ± 0.019	0.566 ± 0.025	0.045	0.114	0.004	*0.014	0.460	0.956
GPe to STN (R)	0.573 ± 0.023	0.584 ± 0.028	0.019	0.063	0.013	*0.032	0.928	0.956

Group means (± StDev), raw p values, and FDR corrected p values from 2 × 2 ANCOVA for free-water corrected fractional anisotropy (FA_T) in each white matter tract, covaried for age and MRI scanner. Significant FDR corrected p values are bolded and indicated by *p < 0.05; **p < 0.01; ***p < 0.001

ISSN: 2040-2392