Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications

Lefebvre, Aline; Traut, Nicolas; Pedoux, Amandine; Maruani, Anna; Beggiato, Anita; Elmaleh, Monique; Germanaud, David; Amestoy, Anouck; Ly-Le Moal, Myriam; Chatham, Christopher; Murtagh, Lorraine; Bouvard, Manuel; Alisson, Marianne; Leboyer, Marion; Bourgeron, Thomas; Toro, Roberto; Dumas, Guillaume; Moreau, Clara; Delorme, Richard

doi:10.1186/s13229-023-00576-z

Molecular Autism

Table 2 Linear regressions between the factors and each cortical, subcortical, cerebellar and callous structures

From: Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications

	Factor 1					Factor 2					Factor 3
	F	R²	Coef	p	FDR	F	R²	Coef	p	FDR	F	R²	Coef	p	FDR
Cortical structures
Left frontal	0.09	0.001	0.12	0.75	0.91	0.003	0.0001	0.03	0.99	0.99	0.04	0.0001	− 0.10	0.85	0.97
Right frontal	0.23	0.002	0.17	0.63	0.90	0.05	0.0001	− 0.12	0.82	0.99	0.17	0.001	− 0.21	0.68	0.97
Left occipital	0.52	0.004	0.16	0.47	0.90	0.0003	0.0001	− 0.01	0.99	0.99	0.49	0.003	− 0.23	0.49	0.97
Right occipital	0.94	0.007	0.22	0.33	0.90	0.51	0.004	0.26	0.48	0.87	0.03	0.0001	− 0.05	0.87	0.97
Left parietal	0.29	0.002	0.16	0.59	0.90	0.16	0.001	− 0.18	0.001	0.10	0.95	0.007	− 0.43	0.33	0.97
Right parietal	1.37	0.01	0.34	0.24	0.90	0.98	0.007	− 0.45	0.32	0.86	2.66	0.02	− 0.69	0.11	0.44
Left temporal	1.02	0.007	0.28	0.31	0.90	0.08	0.001	0.12	0.78	0.99	0.01	0.0001	− 0.04	0.93	0.97
Right tempora	0.64	0.005	0.21	0.42	0.90	0.06	0.0001	− 0.09	0.83	0.99	0.09	0.001	− 0.12	0.76	0.97
Subcortical structures
Left accumbens	0.25	0.002	− 0.09	0.62	0.90	0.54	0.004	0.21	0.46	0.87	0.23	0.002	0.13	0.64	0.97
Right accumbens	0.32	0.002	0.11	0.57	0.90	0.58	0.004	− 0.22	0.45	0.87	0.63	0.005	− 0.22	0.43	0.97
Left amygdala	4.18	0.030	0.41	0.04	0.41	1.89	0.01	− 0.44	0.17	0.75	0.80	0.006	− 0.27	0.37	0.97
Right amygdala	0.10	0.001	− 0.06	0.76	0.91	0.02	0.0001	− 0.04	0.89	0.75	0.002	0.0001	− 0.01	0.97	0.97
Left caudate	0.38	0.003	0.13	0.54	0.90	3.39	0.02	− 0.61	0.07	0.66	2.94	0.02	− 0.53	0.89	0.97
Right caudate	0.64	0.43	0.16	0.43	0.90	2.25	0.02	− 0.48	0.14	0.75	2.65	0.02	− 0.48	0.11	0.44
Left hippocampus	0.02	0.0001	− 0.03	0.89	0.92	0.08	0.001	0.09	0.78	0.98	0.51	0.004	0.23	0.47	0.97
Right hippocampus	0.35	0.002	0.12	0.55	0.90	1.48	0.01	− 0.39	0.23	0.78	0.07	0.001	− 0.08	0.79	0.97
Left pallidum	0.21	0.002	0.13	0.64	0.90	1.04	0.008	− 0.43	0.31	0.86	0.25	0.002	− 0.19	0.62	0.97
Right pallidum	0.17	0.001	− 0.10	0.68	0.90	0.003	0.0001	− 0.02	0.96	0.99	0.004	0.0001	0.02	0.95	0.97
Left putamen	8.84	0.06	0.75	0.003	0.10	8.06	0.06	− 1.12	0.005	0.15	6.20	0.04	− 0.92	0.01	0.41
Right putamen	5.48	0.04	0.58	0.02	0.30	5.31	0.04	− 0.89	0.02	0.33	4.60	0.32	− 0.78	0.03	0.44
Left thalamus	0.04	0.0001	0.05	0.84	0.92	0.08	0.001	− 0.11	0.78	0.99	0.005	0.0001	− 0.03	0.94	0.97
Right thalamus	0.20	0.001	0.11	0.65	0.90	0.58	0.004	− 0.29	0.45	0.86	0.12	0.001	− 0.12	0.73	0.97
Cerebellum
Left Cerebellum	0.01	0.01	0.27	0.19	0.90	1.38	0.01	− 0.37	0.24	0.78	1.03	0.007	− 0.29	0.31	0.97
Right Cerebellum	1.33	0.01	0.24	0.25	0.90	0.83	0.006	− 0.30	0.36	0.87	0.66	0.005	− 0.24	0.42	0.97
Corpus Callosum
Anterior corpus callosum	1.57	0.001	− 0.004	0.19	0.98	0.01	0.0001	0.02	0.93	0.99	0.13	0.001	− 0.09	0.72	0.97
Mid anterior corpus callosum	0.02	0.001	− 0.02	0.89	0.92	0.04	0.0001	0.05	0.84	0.99	0.09	0.001	− 0.07	0.77	0.97
Central corpus callosum	0.33	0.001	0.56	0.56	0.90	0.30	0.002	0.14	0.59	0.99	0.12	0.001	0.08	0.73	0.97
Midposterior corpus callosum	0.57	0.004	0.14	0.45	0.90	2.39	0.02	− 0.43	0.13	0.75	2.98	0.02	− 0.44	0.08	0.44
Posterior corpus callosum	0.02	0.001	0.03	0.89	0.92	1.81	0.01	− 0.46	0.18	0.75	2.89	0.02	− 0.54	0.09	0.44

F value, R-squared, linear regression-derived coefficients (Coef), standard errors (SE) and p value from the linear regressions were reported; FDR: False Discovery Rate was calculated to correct for multiple testing. In bold, non-corrected p value < 0.05

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