Fig. 4

Genetically reducing Tau rescues circadian rhythm defect in Fmr1^−/y mice. A RNA sequencing identified DEGs between mice with different genotypes (FVB;C57BL/6/SV129 mixed background, 2.5 month-old). B DEGS shared by Fmr1^−/y versus WT and Fmr1^−/y;Mapt^± versus Fmr1^−/y groups and their information. C Per1 mRNA levels in the brain of mice with different genotypes were determined by qRT-PCR for comparison. One-way ANOVA followed by Tukey’s post hoc test. WT: n = 4; Mapt^±: n = 4; Fmr1^−/y: n = 4; Fmr1^−/y;Mapt^±: n = 4. D In the autonomous wheel-running test, the activities of different groups of mice were recorded for 5 consecutive days in a constant darkness environment and compared. Two-way repeated-measures ANOVA. WT: n = 3; Mapt^±: n = 3; Fmr1^−/y: n = 3; Fmr1^−/y;Mapt^±: n = 3. ns: not significant, *p < 0.05, ***p < 0.001, ****p < 0.0001