Fig. 2
From: Tau reduction attenuates autism-like features in Fmr1 knockout mice
Genetically reducing Tau prevents autism-like behaviors in Fmr1−/y mice. A–I Fmr1 KO mice and Mapt KO mice were crossed and the offspring (1-month-old, FVB;C57BL/6/SV129 mixed background) were studied for their behaviors. In the open field test, time spent in the center (A), center entry numbers (B), and total travel distance (C) were analyzed. In the nest building test, nesting scores were analyzed (D). In the self-grooming test, grooming time (E) and bout numbers (F) were analyzed. In the three-chamber social interaction test, time spent in each chamber (G), time spent interacting with a Stranger 1 mouse and the empty cage (H), and time spent interacting with the Stranger 1 mouse and a Stranger 2 mouse (I) were analyzed. WT: n = 11; Mapt±: n = 11; Fmr1−/y: n = 9; Fmr1−/y;Mapt±: n = 10. One-way ANOVA followed by Tukey’s post hoc test for (A–F). Two-way ANOVA followed by Bonferroni’s post hoc test for G-I. ns: not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001