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Fig. 5 | Molecular Autism

Fig. 5

From: Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

Fig. 5

RMC-6272 reverses rapamycin-insensitive TSC1-associated alterations in mRNA translation. A, B Scatter plots (similar to Fig. 3A) of transcripts showing TSC1-associated mRNA translation that were reversed (A) or insensitive (B) to rapamycin treatment. The number of transcripts following each pattern of regulation is indicated. C, D Scatter plots of log2 fold changes from NanoString nCounter assays for transcripts showing TSC1-associated mRNA translation that was sensitive (C, left) or insensitive (D, left) to rapamycin (according to RNA sequencing-based quantification) but sensitive to RMC-6272 (C, D, right). Fold changes were calculated between cells treated with rapamycin (left) or RMC-6272 (right) relative to control (DMSO)

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Molecular Autism

ISSN: 2040-2392