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Fig. 4 | Molecular Autism

Fig. 4

From: Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

Fig. 4

Rapamycin partially reverses TSC1- and ASD-associated translation. A, B anota2seq analysis of TSC1−/− cells in the presence versus absence of rapamycin (similar to Fig. 1B, C). C, D ECDF plots for rapamycin sensitivity of eIF4E and synaptic activity signatures in TSC1−/− cells (similar to Fig. 3C, D). E, F Scatter plots (similar to Fig. 3A) assessing how transcripts showing rapamycin-sensitive translation are modulated in the TSC1−/− versus TSC1+/+ NPCs (E) or ASD versus control BA19 (F) comparisons

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Molecular Autism

ISSN: 2040-2392