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Fig. 2 | Molecular Autism

Fig. 2

From: Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations

Fig. 2

ASD-associated alterations of mRNA translation in BA19. A Overview of experimental setup for polysome profiling of BA19 brain samples. Polysome-tracings were obtained using the optimized sucrose gradient as described in “Methods” section. B Characteristics of ASD-affected donors and controls included in the study. C Scatter plot comparing polysome-associated to cytosolic mRNA log2 fold changes for the ASD versus Control BA19 (similar to Fig. 1B). D Kernel densities of p values or FDRs (from anota2seq analysis) for the comparison of ASD versus Control BA19 (similar to Fig. 1C). E Kernel densities of log2 fold changes for total cytosolic and polysome-associated mRNA comparing ASD versus Control BA19. F Gene ontology analysis (similar to Fig. 1F) for the comparison of ASD to Control BA19

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Molecular Autism

ISSN: 2040-2392