Fig. 4
From: The neuroanatomical substrates of autism and ADHD and their link to putative genomic underpinnings
Genomic underpinnings of neurodevelopmental deviations in cortical thickness and surface area in ASD, ADHD, and ASD + ADHD. Panel A and C show the t-maps of the main effect of ASD, the main effect of ADHD and the ASD-by-ADHD interaction term for measures of CT (A) and SA (C). Panel B (CT) and D (SA) show significant odds ratios at a false discovery rate (FDR) corrected p threshold of 0.05 resulting from the gene set enrichment analyses for genes expressed in the different output maps. Gene sets were subdivided into sets with differential gene expression in ASD, sets representing ASD risk genes, and a set representing ADHD risk genes. Gene sets are annotated and labeled based on their original publication. ASD autism spectrum disorder, ADHD attention-deficit/hyperactivity-disorder, CTX cortex, DEG differentially expressed gene, down downregulated expression in ASD, up upregulated expression in ASD, NGenes number of genes in each gene set, CT cortical thickness, SA surface area. *p < 0.05 (FDR-corrected), **p < 0.01 (FDR-corrected); red squares indicate consistently significant enrichments across both approaches (see Additional file11: Figure S6)