Fig. 6

Cortical deletion of Foxp1 alters cytoarchitecture of barrel field. A Double immunolabeling of VGluT2⁺ TCA terminals and SATB2⁺ cortical neurons from P35 WT and the KO mouse brains. DAPI (blue) and SATB2 (red) positive cells formed a ring-like organization around VGluT2⁺ TCA (red) in control mice (Arrow) but not in the Foxp1-cKO cortex. Arrowhead delineates the barrel in layer IV of S1. Scale bar, 200 μm. B Quantifications of VGluT2 fluorescence intensity of layer IV. Circles represent the average fluorescence intensity for each animal (3 animals per genotype; 3 sections per animal). ***p < 0.001. C The density of SATB2⁺ cells in layer IV. Circles represent the average cell density for each animal (3 animals per genotype; 3 sections per animal)