Table 4 Table denoting the odds ratios (ORs) with 95% confidence intervals and false discovery rate (FDR) adjusted p values for our four tiers of model; unadjusted, demographic adjusted, family history adjusted and lifestyle adjusted

Gastrointestinal

20.25

38.56

2.47

p < 0.0001

2.83

p < 0.0001

2.75

p < 0.0001

2.69

p < 0.0001

(2.05–2.98)

(2.26–3.55)

(2.18–3.46)

(2.14–3.39)

Irritable bowel syndrome

11.75

25.00

2.50

p < 0.0001

2.57

p < 0.0001

2.44

p < 0.0001

2.44

p < 0.0001

(2.01–3.14)

(1.99–3.33)

(1.88–3.18)

(1.87–3.17)

Ulcerative colitis (M)

1.88

0.48

0.25

0.11

0.26

0.12

0.26

0.13

0.26

0.14

(0.04–1.06)

(0.05–1.31)

(0.05–1.32)

(0.05–1.39)

Ulcerative colitis (F)

1.12

1.96

1.76

0.21

1.70

0.26

1.73

0.24

1.77

0.74

(0.77–4.25)

(0.71–4.07)

(0.72–4.17)

(0.72–4.35)

Coeliac Disease

0.85

2.13

2.53

0.02

2.76

0.0193

2.17

0.09

2.55

0.0364

(1.24–5.57)

(1.24–6.17)

(0.95–4.96)

(1.13–5.76)

Faecal incontinence

1.11

3.72

3.46

p < 0.0001

(1.90–6.73)

Gastric reflux

8.43

19.77

2.68

p < 0.0001

2.74

p < 0.0001

2.80

p < 0.0001

2.60

p < 0.0001

(2.09–3.46)

(2.03–3.69)

(2.06–3.81)

(1.92–3.53)

Peptic ulcers

1.11

1.95

1.78

0.13

1.81

0.17

1.90

0.14

1.72

0.21

(0.90–3.64)

(0.82–4.03)

(0.85–4.25)

(0.77–3.86)

Hernia (any)

1.19

5.14

4.50

p < 0.0001

4.54

1.0 × 10^–4

4.38

1.8 × 10^–4

4.54

1.4 × 10^–4

(2.57–8.43)

(2.22–9.28)

(2.14–8.98)

(2.2–9.36)

Gastroparesis

0.43

2.22

5.30

1.4 × 10^–3

(2.20–15.80)

Gallbladder disease

0.68

2.22

3.31

5.9 × 10^–3

3.18

0.02

3.09

0.02

2.95

0.04

(1.55–7.86)

(1.27–7.95)

(1.24–7.72)

(1.15–7.61)

Gallstones

1.96

3.99

2.08

7.7 × 10^–3

2.40

6.0 × 10^–3

2.40

6.5 × 10^–3

1.95

0.05

(1.26–3.52)

(1.33–4.33)

(1.33–4.36)

(1.06–3.58)

Diverticulosis

0.85

1.51

1.78

0.19

2.32

0.11

2.30

0.13

2.29

0.13

(0.83–4.05)

(0.87–6.16)

(0.86–6.19)

(0.84–6.26)

Chronic diarrhoea

1.87

7.80

4.43

p < 0.0001

3.92

p < 0.0001

3.87

p < 0.0001

3.71

p < 0.0001

(2.81–7.30)

(2.30–6.68)

(2.26–6.63)

(2.17–6.36)

Chronic constipation

3.75

10.11

2.89

p < 0.0001

3.22

p < 0.0001

3.22

p < 0.0001

2.96

p < 0.0001

(2.04–4.17)

(2.13–4.88)

(2.10–4.94)

(1.94–4.51)

Functional pain

0.94

3.55

3.89

2.1 × 10^–4

(2.06–8.00)

Haemorrhoids

4.77

9.66

2.14

p < 0.0001

2.20

3.4 × 10^–4

2.16

6.2 × 10^–4

2.06

1.4 × 10^–3

(1.54–3.00)

(1.47–3.31)

(1.43–3.27)

(1.36–3.11)

GI polyps

1.70

3.64

2.18

7.7 × 10^–3

2.29

0.02

2.23

p < 0.0001

2.33

0.0201

(1.28–3.81)

(1.19–4.42)

(1.15–4.32)

(1.20–4.53)

Endocrine

17.02

20.57

1.56

0.04

1.54

8.8 × 10^–4

1.31

0.01

1.48

3.8 × 10^–3

(1.26–1.56)

(1.21–1.96)

(1.10–1.81)

(1.15–1.89)

Polycystic ovarian syndrome (F)

5.23

8.81

1.75

0.01

1.85

5.8 × 10^–3

1.89

5.0 × 10^–3

1.59

0.05

(1.17–2.64)

(1.22–2.80)

(1.25–2.88)

(1.04–2.43)

Premenstrual tension (F)

8.59

13.99

1.73

1.8 × 10^–3

1.89

4.3 × 10^–3

1.54

0.02

1.81

1.6 × 10^–3

(1.25–2.40)

(1.35–2.64)

(1.09–2.18)

(1.28–2.55)

Endometriosis (F)

3.74

6.57

1.81

0.02

2.09

4.8 × 10^–3

1.98

0.01

1.89

0.02

(1.14–2.93)

(1.29–3.39)

(1.21–3.23)

(1.15–3.09)

Fibroids (F)

3.61

2.79

0.77

0.40

0.92

0.78

0.63

0.19

0.81

0.54

(0.43–1.36)

(0.50–1.67)

(0.33–1.22)

(0.44–1.50)

Precocious puberty

0.60

1.77

2.01

0.02

(1.33–7.70)

Hypothyroidism

6.13

6.11

1.00

0.99

1.28

0.22

1.11

0.61

1.17

0.45

(0.71–1.40)

(0.89–1.84)

(0.76–1.62)

(0.80–1.71)

Hyperthyroidism

1.45

1.41

0.98

0.97

(0.49–1.96)

Rheumatological

14.72

25.44

1.98

p < 0.0001

2.33

p < 0.0001

2.2

p < 0.0001

2.16

p < 0.0001

(1.60–2.44)

(1.81–3.01)

(1.69–2.87)

(1.66–2.80)

Rheumatoid arthritis

2.30

3.28

1.44

0.19

1.27

0.48

1.18

0.63

1.31

0.45

(0.88–2.41)

(0.68–2.39)

(0.63–2.23)

(0.69–2.48)

Osteoarthritis

6.81

8.16

1.22

0.24

1.44

0.09

1.43

0.13

1.39

0.14

(0.89–1.66)

(0.96–2.16)

(0.93–2.20)

(0.92–2.09)

Carpal tunnel syndrome

1.87

5.14

2.84

1.2 × 10^–4

3.53

p < 0.0001

3.83

p < 0.0001

3.46

p < 0.0001

(1.75–4.77)

(2.01–6.21)

(2.13–6.89)

(1.95–6.13)

Scoliosis

2.21

3.90

1.79

0.03

1.65

0.09

1.54

0.16

1.61

0.21

(1.11–2.97)

(0.95–2.87)

(0.87–2.72)

(0.92–2.82)

Spinal stenosis

1.91

1.24

1.04

0.94

1.81

0.26

1.87

0.24

1.61

0.13

(0.49–2.21)

(0.67–4.89)

(0.68–5.13)

(0.92–2.82)

Slipped disc

1.79

4.97

2.87

1.4 × 10^–4

3.34

6.1 × 10^–4

2.84

4.5 × 10^–3

3.09

1.8 × 10^–3

(1.75–5.88)

(1.74–6.42)

(1.45–5.56)

(1.59–6.01)

Fibromyalgia

1.79

6.65

3.91

p < 0.0001

3.95

p < 0.0001

3.69

p < 0.0001

3.49

p < 0.0001

(2.44–6.55)

(2.37–6.68)

(2.18–6.26)

(2.04–5.95)

Hypermobility (F)

0.62

4.48

7.48

1.1 × 10^–4

7.47

1.1 × 10^–4

5.62

1.2 × 10^–3

6.05

6.7 × 10^–4

(3.17–21.97)

(2.87–19.44)

(2.11–15.00)

(2.30–15.9)

Ehler-Danlos syndrome (F)

0.87

6.29

7.64

p < 0.0001

7.74

p < 0.0001

6.81

p < 0.0001

7.34

p < 0.0001

(3.65–18.65)

(3.44–17.42)

(2.97–15.60)

(3.23–16.65)

Neurological

17.87

29.70

1.94

p < 0.0001

2.24

p < 0.0001

2.16

p < 0.0001

2.14

p < 0.0001

(1.60–2.36)

(1.77–2.83)

(1.71–2.73)

(1.68–2.71)

Migraine

14.81

22.70

1.69

p < 0.0001

1.81

p < 0.0001

1.76

p < 0.0001

1.74

p < 0.0001

(1.37–2.09)

(1.41–2.31)

(1.36–2.28)

(1.35–2.24)

Epilepsy (M)

2.96

1.94

0.65

0.39

0.68

0.47

 0.67

 0.42

0.69

0.50

(0.25–1.62)

(0.25–1.80)

 (0.25-1.78)

(0.25–1.90)

Epilepsy (F)

1.12

5.18

4.81

1.0 × 10^–4

5.09

p < 0.0001

4.65

2.1 × 10^–4

4.69

2.0 × 10^–4

(2.41–10.69)

(2.40–10.78)

(2.18–9.90)

(2.20–10.02)

Syncope

1.02

3.64

3.66

2.3 × 10^–4

4.19

2.1 × 10^–4

4.00

3.9 × 10^–4

4.00

5.0 × 10^–4

(1.97–7.30)

(2.05–8.57)

(1.95–8.21)

(1.94–8.27)

Vertigo

1.28

3.64

2.92

9.5 × 10^–4

4.00

2.5 × 10^–4

4.33

2.1 × 10^–4

3.73

7.0 × 10^–4

(1.64–5.47)

(1.99–8.05)

(2.10–8.93)

(1.83–7.58)

Chronic Fatigue syndrome

2.21

6.56

3.10

p < 0.0001

3.33

p < 0.0001

3.17

p < 0.0001

3.19

p < 0.0001

(2.00–4.97)

(2.03–5.50)

(1.92–5.24)

(1.92–5.29)

Ocular

35.83

44.24

1.42

1.2 × 10^–4

1.63

p < 0.0001

1.54

3.9 × 10^–4

1.61

p < 0.0001

(1.20–1.68)

(1.31–2.01)

(1.23–1.93)

(1.29–2.00)

Nearsightedness

28.40

31.10

1.14

0.19

1.26

0.06

1.19

0.19

1.24

0.07

(0.95–1.36)

(1.01–1.58)

(0.93–1.51)

(0.98–1.56)

Farsightedness

8.51

11.35

1.38

0.03

1.32

0.11

1.26

0.20

1.32

0.13

(1.05–1.82)

(0.96–1.82)

(0.90–1.76)

(0.95–1.83)

Astigmatism

18.30

25.10

1.50

2.2 × 10^–4

1.76

p < 0.0001

1.70

1.2 × 10^–4

1.75

p < 0.0001

(1.22–1.83)

(1.38–2.25)

(1.32–2.19)

(1.36–2.25)

Blurred vision

1.53

4.43

2.98

2.3 × 10^–4

3.19

1.2 × 10^–3

3.00

1.9 × 10^–3

2.93

2.8 × 10^–4

(1.76–5.28)

(1.62–5.95)

1.56–5.76)

(1.52–5.66)

Diplopia

0.77

2.75

3.66

1.3 × 10^–3

(1.81–8.20)

Colourblindness

1.19

1.60

1.34

0.43

3.53

0.08

3.37

0.08

2.98

0.14

(0.67–2.76)

(0.93–13.4)

(0.88–12.96)

(0.77–11.5)

Strabismus

0.94

2.57

2.79

6.7 × 10^–3

(1.43–5.87)

Amblyopia

3.15

6.29

2.07

9.7 × 10^–3

2.11

5.1 × 10^–3

2.03

8.8 × 10^–3

2.01

0.01

(1.39–3.13)

(1.29–3.47)

(1.23–3.35)

(1.21–3.34)

Cataract

3.83

3.46

0.90

0.66

0.87

0.67

0.88

0.69

0.92

0.79

(0.58–1.39)

(0.46–1.63)

(0.47–1.66)

(0.48–1.74)

Blindness

1.87

2.75

1.48

0.19

2.3

0.07

2.23

0.08

2.06

0.12

(0.86–2.60)

(1–5.28)

(0.97–5.14)

(0.89–4.80)

Otolaryngology

9.70

17.73

2.01

p < 0.0001

1.96

p < 0.0001

1.82

2.1 × 10^–4

1.87

1.2 × 10^–4

(1.57–2.57)

(1.46–2.62)

(1.35–2.45)

(1.39–2.51)

Deafness

1.02

2.93

2.92

2.9 × 10^–3

2.18

0.07

2.02

0.11

2.1

0.09

(1.54–5.92)

(0.99–4.79)

(0.92–4.47)

(0.95–4.68)

Tinnitus

2.13

7.89

3.94

p < 0.0001

3.91

p < 0.0001

3.81

p < 0.0001

3.81

p < 0.0001

(2.55–6.31)

(2.26–6.76)

(2.19–6.62)

(2.19–6.63)

Mouth ulcers

2.55

5.76

2.33

3.6 × 10^–4

2.18

3.6 × 10^–3

2.11

5.9 × 10^–3

2.06

8.7 × 10^–3

(1.52–3.67)

(1.33–3.57)

(1.29–3.48)

(1.24–3.40)

TMJ syndrome

1.11

3.72

3.46

2.5 × 10^–4

4.06

1.2 × 10^–3

3.63

9.8 × 10^–4

3.62

5.8 × 10^–4

(1.90–6.73)

(2.07–7.94)

(1.77–7.46)

(1.83–7.14)

Renal/hepatic

3.75

8.33

2.34

p < 0.0001

2.48

1.3 × 10^–4

2.32

5.2 × 10^–4

2.21

1.1 × 10^–3

(1.63–3.40)

(1.60–3.84)

(1.49–3.62)

(1.41–3.46)

Non-alcoholic fatty liver disease

0.51

1.51

2.98

0.03

(1.23–8.29)

Kidney stones

1.02

1.68

1.66

0.20

1.36

0.54

1.28

0.63

1.19

0.74

(0.81–3.53)

(0.53–3.49)

(0.49–3.30)

(0.45–3.1)

Urinary incontinence

1.02

3.99

4.03

p < 0.0001

5.20

p < 0.0001

5.32

p < 0.0001

4.57

1.7 × 10^–4

(2.19–8.00)

(2.53–10.70)

(2.54–11.20)

(2.18–9.54)

Haematological

7.40

11.34

1.60

2.3 × 10^–3

1.75

8.6 × 10^–4

1.67

3.1 × 10^–3

1.76

2.1 × 10^–3

(1.21–2.14)

(1.28–2.39)

(1.21–2.29)

(1.28–2.41)

Iron deficiency anaemia

5.79

8.78

1.57

9.3 × 10^–3

1.74

2.8 × 10^–3

1.69

5.8 × 10^–3

1.74

3.6 × 10^–3

(1.14–2.16)

(1.24–2.45)

(1.19–2.4)

(1.22–2.47)

Dermatological

21.78

29.97

1.54

p < 0.0001

1.67

p < 0.0001

1.70

p < 0.0001

1.65

p < 0.0001

(1.27–1.85)

(1.33–2.09)

(1.35–2.14)

(1.32–2.08)

Eczema

16.25

21.28

1.39

3.7 × 10^–3

1.50

2.4 × 10^–3

1.56

1.3 × 10^–3

1.48

4.0 × 10^–3

(1.13–1.72)

(1.17–1.92)

(1.21–2.01)

(1.15–1.90)

Psoriasis

3.75

7.54

2.09

2.5 × 10^–5

1.76

0.02

1.76

0.02

1.70

0.06

(1.45–3.07)

(1.12–2.76)

(1.11–2.79)

(1.07–2.68)

Acne

7.40

13.03

1.87

p < 0.0001

2.18

p < 0.0001

2.09

p < 0.0001

2.19

p < 0.0001

(1.42–2.48)

(1.57–3.04)

(1.48–2.95)

(1.57–3.07)

Hyperhidrosis

0.51

1.86

3.70

7.8 × 10^–3

(1.58–10.10)

Rosacea

0.68

1.24

1.83

0.20

(0.78–4.61)