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Table 1 WT and Tmlhe-KO mouse performance in social behavior, motor function and cognition tests

From: Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels

Tests

Male

Female

WT

Tmlhe-KO

WT

Tmlhe-KO

Social interaction (s)

88 ± 9

82 ± 14

79 ± 13

95 ± 20

Marble buried (%)

70 ± 12

86 ± 4

83 ± 6

80 ± 7

Nest build, score

8 ± 1

8 ± 1

6 ± 1

6 ± 1

Grip strength, g/g body weight

8 ± 0.3

8 ± 0.4

8 ± 0.6

8 ± 0.7

Rota-rod (s)

238 ± 20

242 ± 22

249 ± 16

233 ± 18

Passive avoidance (s)

86 ± 57

87 ± 33

100 ± 40

78 ± 26

Y-maze (% alternation)

60 ± 3

68 ± 5

69 ± 5

63 ± 5

Survival at 23 months of age (%)

55.6

63.6

75.0

81.8

  1. Data are expressed as the mean ± SEM of 9–14 animals per group. Statistical analysis revealed no significant differences between Tmlhe-KO and WT mice in the performance of any behavioral test and survival (two-way ANOVA followed by unpaired t-test and Log-rank test to calculate Chi square of survival curves)
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Molecular Autism

ISSN: 2040-2392