Fig. 1

TML, GBB, and carnitine concentrations in WT and Tmlhe-KO mouse brains (A) and plasma (B). Concentrations of GBB and carnitine were significantly lower in KO mice than in WT mice. Each value is the mean (± SEM) of 5–8 mice. **p < 0.0001 compared to the WT group (two-way ANOVA followed by unpaired t-test). Coresponding F and p values are: plasma TML F_{3, 16} = 28.48, p < 0.0001; plasma GBB F_{3, 16} = 22.62, p < 0.0001; plasma carnitine F_{3, 16} = 168.6, p < 0.0001; brain TML F_{3, 25} = 741.5, p < 0.0001; brain GBB F_{3, 24} = 457.6; p < 0.0001, brain carnitine F_{3, 25} = 479.6; p < 0.0001