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Fig. 1 | Molecular Autism

Fig. 1

From: Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance

Fig. 1

The flowchart of the study design. A total of 600 ASDs and 729 NCs from Autism Brain Imaging Data Exchange (ABIDE) were included in the study, and the gray matter volume (GMV) was calculated based on the voxel-based morphometry (VBM) analysis. Then, the person-based similarity index (PBSI) scores for GMV were calculated in each subject. Based on the regional contributions to PBSI scores, BrainAGE models were constructed using different machine learning methods, and the correlations between the difference of regional contributions to PBSI scores and gene expression were explored. Abbreviation ABIDE: Autism Brain Imaging Data Exchange; ASD, Autism spectrum disorder; GPR, Gaussian process regression; MRI, magnetic resonance imaging; NC, normal control; PBSI, person-based similarity index; RVR, relevance vector regression; SVR, support vector regression; VBM, voxel-based morphometry

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Molecular Autism

ISSN: 2040-2392