Effects of multiple-dose intranasal oxytocin administration on social responsiveness in children with autism: a randomized, placebo-controlled trial

Table 1 Demographic characteristics of the trial participants at baseline (T0), separately for the oxytocin and placebo groups

	Oxytocin		Placebo		t-value	p value
	n	mean ± SD	n	mean ± SD	t-value	p value
Age	38	10.48 ± 1.32	39	10.39 ± 1.23	0.28	0.779
Sex	30 M/8 F		31 M/8 F
Handedness	35 R/3 L		33 R/6 L
WISC-V
Verbal IQ	37	105.84 ± 14.41	38	109.42 ± 15.77	-1.03	0.308
Performance IQ	38	104.05 ± 15.36	38	101.66 ± 12.75	0.74	0.462
ADOS-2
Total	33	9.48 ± 3.78	32	9.16 ± 4.15	0.33	0.740
Social Affect	31	7.13 ± 3.55	32	7.47 ± 3.72	-0.37	0.712
Restricted and repetitive behavior	31	2.10 ± 1.19	31	1.71 ± 1.30	1.22	0.226
SRS-2 total t-score	38	87.10 ± 13.30	39	87.10 ± 12.25	0.32	0.752
Primary outcome
SRS-2 total raw score	38	89.26 ± 21.66	39	87.87 ± 20.03	0.29	0.771
Secondary outcomes—parent report
RBS-R	38	27.29 ± 15.24	39	26.64 ± 16.43	0.18	0.858
SCARED parent	38	39.74 ± 21.74	39	45.15 ± 18.31	-1.18	0.240
Secondary outcomes—self-report
SCARED child	38	38.29 ± 20.99	39	39.05 ± 20.21	-0.16	0.872
ASCQ Anxious	38	13.45 ± 5.19	39	12.85 ± 4.15	0.56	0.575
ASCQ Avoidant	38	13.79 ± 4.00	39	14.08 ± 3.86	-0.32	0.749
ASCQ Secure	38	19.97 ± 3.50	39	19.23 ± 2.78	1.03	0.305
Attachment Mother Anxiety	38	4.74 ± 2.89	39	4.82 ± 2.78	-0.13	0.897
Attachment Mother Avoidance	38	9.05 ± 4.76	39	7.97 ± 4.03	1.07	0.286
Attachment Mother Secure	38	16.76 ± 4.24	39	17.87 ± 3.13	-1.31	0.195

			Pearson Chi-square	p value
Co-occurring conditions	15	15	0.01	0.927
Psychoactive Medication	22	23	0.01	0.923
Psychosocial Training (> 2 sessions/month)	10	8	0.36	0.547

Data are shown as mean ± standard deviation. Values printed in bold are significant differences with p-values smaller than 0.05
M male, F female, R right, L left, WISC-V Wechsler intelligence scale for children, ADOS autism diagnostic observation schedule, SRS-2 social responsiveness scale, RBS-R repetitive behavior scale-revised, SCARED screen for child anxiety related disorders, ASCQ attachment style classification questionnaire.

ISSN: 2040-2392