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Fig. 7 | Molecular Autism

Fig. 7

From: Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

Fig. 7

No differences between WT and Fmr1−/y rats in the power of hippocampal oscillatory activity. A Top: Example CA1 LFP traces bandpass filtered for theta (6–12 Hz) from a WT (black) and an Fmr1−/y (red) rat. Bottom: Box and whisker plots depicting theta power (6–12 Hz) for each session. The middle line represents rat median, upper and lower end of the box represents 95th and 5th percentile, whiskers represent maximum and minimum values. There was a significant decrease in theta power across sessions within a day (p = 0.021) but no significant difference between genotypes (p = 0.367) or days (p = 0.581) and no significant interactions. B Slow gamma (30–45 Hz) (same layout as in A) exhibited no significant differences between genotypes (p = 0.184), days (p = 0.735) or sessions within a day (p = 0.817) and no significant interactions. C Medium gamma (55–100 Hz) (same layout as in A) exhibited no significant differences between genotypes (p = 0.103), days (p = 0.521) or sessions within a day (p = 0.265) and no significant interactions. Statistical analysis used 3-way ANOVA (genotype, day, session in day). NWT = 7, NKO = 7. Pale yellow and pale purple backgrounds denote data from Day 1 and Day 2, respectively

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