Fig. 9
From: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice
Effects of Myt1l haploinsufficiency on motor performance and learning on the accelerating rotarod. A Motor performance in the standard task with an accelerating rotarod (4–40 rpm) is reduced in Myt1l+/- mice and reflected in a lower latency to fall, despite evidence for intact motor learning. Repeated-measures ANOVA with the between-subject factors genotype (G) and sex (S) and the within-subject factor trial (T), followed by unpaired t tests when appropriate. T: F1,260 = 51.953; p < .001; G: F1,52 = 7.309; p = .009; S: F1,52 = 11.197; p = .002; all other p > 0.050. B Motor performance in the challenge task with an accelerating rotarod (8–80 rpm) is reduced in Myt1l+/- mice and reflected in a lower latency to fall. Repeated-measures ANOVA with the between-subject factors genotype (G) and sex (S) and the within-subject factor trial (T), followed by unpaired t tests when appropriate. T: F1,260 = 6.701; p < .001; TxS: F5,260 = 2.512; p = .030; G: F1,52 = 8.933; p = .004; S: F1,52 = 21.467; p < .001; all other p > 0.050. All data are means ± SEM, combined across males and females; *p < 0.05; **p < 0.01; ***p < 0.001