Fig. 2
From: Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice
Myt1l is essential for postnatal survival. A Genotype distribution of Myt1l offspring at various ages. The dashed bars represent the expected percentage of mice for a genotype, assuming Mendelian inheritance from two heterozygous parents. The solid bars show the observed distribution based on 10–13 litters. Approximately 25% of mice were WT, 50% HET, and 25% KO at ages E13.5, E15.5, and E18.5. In contrast, only 12% of KO were present at PND 0. Numbers in bars represent number of mice per genotype/total number of mice. The chi-square test indicated a significant difference between the expected and observed distribution of KO pups at PND 0 (p = 0.011). n.s. = not significant; *p < 0.05. B Kaplan–Meier survival curve comparing the three genotypes after birth. WT and HET survive past PND 7, while all Myt1l KO die by PND 1. A logrank Mantel–Cox test showed a significant trend for the survival probability of KO pups (p = 0.0019)