Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome

Table 1 Dup15q syndrome participant characteristics

Age (months)	Gender	Duplication type	Epilepsy (active)	Spike-wave index in sleep	Medications (generic)
105	Female	Isodicentric	No	< 35%	Risperidone Melatonin
23	Female	Isodicentric	No	< 35%	None
108	Female	Isodicentric	No	< 35%	None
18	Male	Interstitial	No	< 35%	None
35	Male	Isodicentric	No	< 35%	None
54	Male	Isodicentric	No	< 35%	None
68	Female	Isodicentric	Yes	45–50%	Clobazam Topiramate
137	Male	Isodicentric	Yes	40–45%	Topiramate
73	Female	Interstitial	Yes	< 35%	Lamotrigine Guanfacine
19	Male	Isodicentric	Yes	35–40%	Vigabatrin Prednisolone
57	Female	Isodicentric	Yes	< 35%	None
9	Female	Isodicentric	Yes	< 35%	Levetiracetam Phenobarbital
55	Male	Isodicentric	Yes	65–70%	None
108	Male	Isodicentric	Yes	< 35%	None
156	Male	Isodicentric	Yes	40–45%	None

This table describes the characteristics of participants in the Dup15q syndrome cohort. Details on age, gender, epilepsy status and medications were extracted from participant background questionnaires, and duplication type was extracted from participant genetic reports. The percentage of sleep occupied by spike-waves was reported as the spike-wave index in clinical EEG reports and was verified by a board-certified pediatric epileptologist
Dosages were not available for all the medications listed, hence not included in the table

ISSN: 2040-2392