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Table 8 Univariate regression (β) coefficients for sulforaphane compared to placebo for biomarker gene expression (change from baseline)

From: Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

  β coefficient 95% CI p value
HO-1
 Week 7 − 0.50 (− 1.13, 0.14) 0.121
 Week 15 − 0.84 (− 1.50, − 0.19) 0.013
HSP70
 Week 7 − 0.41 (− 0.90, 0.07) 0.091
 Week 15 − 0.78 (− 1.45, − 0.10) 0.025
HSP27
 Week 7 − 0.04 (− 0.27, 0.18) 0.693
 Week 15 − 0.31 (− 0.66, 0.04) 0.078
IL-6
 Week 7 − 0.39 (− 0.94, 0.17) 0.166
 Week 15 − 1.31 (− 2.22, − 0.39) 0.006
IL-1β
 Week 7 − 1.13 (− 2.11, − 0.14) 0.026
 Week 15 − 0.76 (− 1.88, 0.35) 0.174
 Week 22 − 0.26 (− 1.36, 0.83) 0.627
 Week 30 − 1.32 (− 2.55, − 0.09) 0.037
TNF-α
 Week 7 − 0.18 (− 0.62, 0.25) 0.394
 Week 15 − 0.56 (− 0.98, − 0.14) 0.010
  1. Bold signifies p < 0.05
  2. Analysis based on natural log transformed fold change values. See complete Additional file 1: Table S18