Autism-associated biomarkers: test–retest reliability and relationship to quantitative social trait variation in rhesus monkeys

Table 3 Principal component analysis including biological measures and mSRS-R score

Variable	PC1	PC2	PC3
mSRS-R score	0.124757	− 0.068776	− 0.573300
CSF AVP concentration (pg/ml)	0.128673	0.138965	0.791405
CSF OXT concentration (pg/ml)	− 0.051712	0.895863	0.105542
Blood AVPR1A mRNA level (− ΔCT)	0.806013	− 0.295566	0.310247
Blood OXTR mRNA level (− ΔCT)	0.949433	− 0.082827	− 0.268385
Total neuropeptide receptor gene expression	0.976782	− 0.176406	− 0.058269
Differential neuropeptide receptor gene expression	− 0.627836	− 0.121857	0.599418
Blood p-ERK/ERK ratio	0.189370	− 0.394305	0.021212
Blood p-PTEN/PTEN ratio	0.028608	− 0.785099	− 0.129737

Variables with loadings greater than ± 0.4 are considered meaningful (per standard convention) [49] and are noted in bold. Weaker loadings are shown, but greyed out
mSRS-R, macaque Social Responsiveness Scale-Revised; PC, principal component; CSF, cerebrospinal fluid; AVP, arginine vasopressin; OXT, oxytocin

ISSN: 2040-2392