Autism-associated biomarkers: test–retest reliability and relationship to quantitative social trait variation in rhesus monkeys

Table 2 Within-individual consistency in biological measures

Biological measure	N	ICC ± SE	P
CSF AVP level (pg/ml)	42	58.1% ± 16.2%	0.0003
CSF OXT level (pg/ml)	43	42.0% ± 13.8%	0.0023
Blood AVPR1A mRNA level (−ΔCT)	43	72.7% ± 18.0%	< 0.0001
Blood OXTR mRNA level (−ΔCT)	43	56.5% ± 16.0%	0.0004
Total neuropeptide receptor gene expression	43	67.3% ± 17.4%	0.0001
Differential neuropeptide receptor gene expression	43	50.6% ± 15.0%	0.0007
Blood p-ERK/ERK ratio	42	42.8% ± 14.2%	0.0027
Blood p-PTEN/PTEN ratio	42	88.6% ± 20.4%	< 0.0001
Blood p-AKT/AKT ratio	43	18.5% ± 11.1%	0.0950

ICC, intra-class correlation coefficient; SE, standard error; CSF, cerebrospinal fluid; AVP, arginine vasopressin; OXT, oxytocin

ISSN: 2040-2392