Fig. 4

Somatosensory adaptation to repeated tactile stimulation. a The mean amplitude difference between long and short ISI is shown for the early and mid-latency SEP responses over the contralateral somatosensory cortex for the NT (blue) and AS (wine red) groups. Note that positive values represent greater adaptation. b Grand-averaged SEP traces in response to passive tactile stimulation from ROIs over the contralateral somatosensory cortex for the NT (blue) and AS (wine red) groups are shown for the long ISI (1050 ms, solid line) and the short ISI (150 ms, dashed line). The adaptation of early and mid-latency SEP responses (P50, N80, P100) can be seen as the difference between long and short ISI (see A). The time window of later SEP responses overlapped with the SEP to the subsequent stimulus in the short ISI condition and thus did not allow for an assessment of adaptation of these later responses (greyed-out portion of SEP traces). Error bars (a) and shaded area (b) represent between-participant SEM. Statistical difference from zero: **p < 0.01