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Fig. 2 | Molecular Autism

Fig. 2

From: Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development

Fig. 2

Neonatal ultrasonic vocalization emissions, developmental growth, neurological reflexes and developmental delays in Arid1b+/−. a Across neonatal developmental life, Arid1b+/− pups displayed abnormal ultrasonic vocalization (USVs) emissions including delay of peak number of calls and decreased total number of USVs on several days compared to Arid1b+/+. b When summed, Arid1b+/− pups emitted significantly fewer USVs compared to Arid1b+/+ littermate controls. c No genotype difference in axillary abdominal temperature was found, confirming fewer USVs were not the result of neonatal hypothermia. d Arid1b+/− weighed less across development beginning at postnatal 8 and continuously throughout development compared to sex-matched Arid1b+/+. e Across neonatal developmental life, Arid1b+/− pups were shorter by body length (f) and narrower by head width measurements. g While Arid1b+/− showed normal latencies to perform the righting reflex, a measure of limb coordination in early life, h Arid1b+/− had prominent deficits in negative geotaxis (i.e., incline reorientation) and i the ability to traverse out of circle by walking. For ac, Arid1b+/+ N = 40, Arid1b+/− N = 19, for di Arid1b+/+ N = 29, Arid1b+/+ N = 18. * p < .05 versus Arid1b+/+ by repeated measures two-way ANOVA or student’s unpaired t test. Error bars represent mean ± SEM

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