Table 4 Comparison with past literature
From: Prospective and detailed behavioral phenotyping in DDX3X syndrome
| Â | Current study | Snijders Blok, 2015 | Wang, 2018 | Beal, 2019 | Lennox, 2020 |
|---|---|---|---|---|---|
Sample size (F,M) | 14,1 | 38,0 | 28,0 | 6,0 | 104,3 |
ID | 80%* | ID and/or other delays, 100% | ID and/or other delays, 100% | 50% | ND |
Motor delays | 87%* | Speech/motor delays, 67% | ND | ||
Speech delays | 93%* | ND | |||
ASD | 60%* | One or more of ASD, hyperactivity, and aggression, 53% | ASD and/or other behavioral problems, 21% | One or more of ASD, hyperactivity, and aggression, 33% | 21% |
ADHD | 53%* | 15% | |||
Generalized anxiety disorder | 7%* | ND | ND | ND | ND |
Visual motor integration abnormalities | 54%* | ND | ND | ND | ND |
Abnormal expressive language1 | 80%* | ND | ND | ND | ND |
Abnormal receptive language2 | 73%* | ND | ND | ND | ND |
Sensory symptoms | 100%* | ND | ND | ND | ND |
Gait disturbance/movement disorders | 100%* | 45% | 61% | 33% | ND |
Hypotonia | 93%* | 76% | 68% | 0% | 82% |
Gastrointestinal abnormalities | 80% | ND | ND | ND | ND |
Ocular/vision abnormalities | 73%* | 34% | 32% | 50% | 36% |
Sleep disturbance | 67%* | ND | ND | 33% | ND |
Abnormal brain MRI | 86%* | 57% | 90% | 25% | 94%* |
Corpus callosum abnormalities | 64%* | 35% | ND | 25% | 87%* |
Polymicrogyria/cortical dysplasia | 7%* | 11% | ND | 0% | 12%* |
Epilepsy/seizures | 13% | 16% | ND | 17% | 20% |
Cardiac defects/disease | 7% | ND | 71%3 | 17% | 15% |
Precocious puberty | 20% | 13% | ND | 0% | 8% |