Fig. 4

Sensory reactivity. a Frequency histograms for the Sensory Assessment for Neurodevelopmental Disorders (SAND) hyperreactivity, hyporeactivity and sensory seeking domains. Distribution of standard scores in typically developing individuals are shown as black lines, together with associated standard deviations (dashed lines). b Average Z-scores for hyperreactivity, hyporeactivity, and seeking within visual, tactile, and auditory modalities. Z-scores have a mean of 0 where + 1 indicates 1 SD above the mean. PTV, protein-truncating variant; missense, missense variant or in-frame deletion