Fig. 3
From: Prospective and detailed behavioral phenotyping in DDX3X syndrome
Psychiatric features. a Frequency histograms for the Autism Diagnostic Interview-Revised (ADI-R) Socialization, Communication, and Restricted/Repetitive Behavior (RRB) domains. Dashed lines represent the diagnostic threshold for ASD for each domain, with scores to the right surpassing the threshold. b Frequency histograms for the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) comparison score. Evidence levels for ASD are categorized as minimum-to-no evidence, low, moderate, and high evidence. c Frequency histograms for the Social Responsiveness Scale (SRS-2) total score. Total score has a mean of 50 and standard deviation of 10. d Frequency histograms for the Repetitive Behaviors Scale-Revised (RBS-R). Total scores have a minimum of 0 and maximum of 129. In all plots, higher scores indicate greater deficits. In c, d, distribution of standard scores in typically developing individuals are shown as black lines, together with associated standard deviations (dashed lines). PTV, protein-truncating variant; missense, missense variant or in-frame deletion