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Fig. 4 | Molecular Autism

Fig. 4

From: High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons

Fig. 4

Primary screening of a pharmaceutical compound library. a Composition of the compound library (1478 compounds). b Robustness of primary HTS setup. For each batch of plates, control run statistics with average Ct values (Avg.) of GAPDH and SRSF9 housekeeping genes, their SD and CV are summarized. c Exclusion and inclusion criteria of the primary screening.  d Scatter plot of the primary screening. All compounds were tested at 10 μM for 48 h. Fold changes compared with DMSO control were plotted for each gene (BAZ1B, CLIP2, EIF4H, GTF2I) in WBS01CN3 NGN2 neurons. Selected hits are shown for GTF2I

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Molecular Autism

ISSN: 2040-2392