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Fig. 3 | Molecular Autism

Fig. 3

From: Ribosome profiling in mouse hippocampus: plasticity-induced regulation and bidirectional control by TSC2 and FMRP

Fig. 3

FMRP binding targets are regulated by TSC and FMRP in opposing directions. a Empirical cumulative distribution function (ECDF) of RNA (left), RPF (middle), and TE (right) expression changes in Tsc2+/−/WT (log2FC) of FMRP binding targets compared to nontarget mRNAs. FMRP binding targets are stratified into three groups based on binding stringency. Wilcoxon rank-sum test with correction by Bonferroni method. p values are indicated in the plot legend. b ECDF of RNA (left), RPF (middle), and TE (right) expression changes in Fmr1−/y/WT (log2FC) of FMRP targets compared to nontarget mRNAs. Data of hippocampal slices of Fmr1−/y mice from Shah et al. [76]. Wilcoxon rank-sum test with correction by Bonferroni method. p values are indicated in the plot legend. c The levels of FMRP as determined by western blots of fresh, whole hippocampus from wild-type and Tsc2+/− littermate. n = 5 animals, ns nonsignificant, unpaired t test

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Molecular Autism

ISSN: 2040-2392