Fig. 2

Behavioral testing of Ube3a^mLSL/Nestin-Cre mice show a full rescue of most AS-like behavioral phenotypes. a Schematic representation of Ube3a gene reactivation during mouse embryonic development around 2 weeks of gestation and time point of behavioral testing. b–e Accelerating rotarod test, nest building test, marble burying test, and forced swim test in WT and Ube3a^mLSL mice (WT, n = 28; Ube3a^mLSL/Cre⁻, n = 14; Ube3a^mLSL/Cre⁺, n = 12). A repeated measures ANOVA or univariate ANOVA was used for statistical comparison of genotypes. Asterisk indicate significant effects of genotype: *P < 0.05; **P < 0.01; ***P < 0.001