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Table 2 Global differences in MNS activation during action observation

From: Differential mirror neuron system (MNS) activation during action observation with and without social-emotional components in autism: a meta-analysis of neuroimaging studies

Brain regions with peak activation Cluster breakdown
Anatomical region L/R Total number of voxels MNI coordinates SDM-Z p (uncorrected) Anatomical regions
(Broadmann area)
ASD > TD
 Inferior frontal gyrus, orbital part R 1077 48,28, − 4 2.827 ~0 Inferior frontal gyrus, orbital part (BA47)
Inferior frontal gyrus, orbital part (BA45)
Inferior frontal gyrus, triangular part (BA45)
 Supplementary motor area L 525 − 4,8,54 2.044 < 0.0005 Supplementary motor area (BA6)
 Inferior parietal lobule L 46 − 52, − 40,40 1.710 < 0.005 Inferior parietal lobule (BA40)
ASD < TD
 Precentral gyrus L 692 − 42, − 6,48 − 2.169 < 0.0001 Precentral gyrus (BA6)
Postcentral gyrus (BA6)
 Amygdala R 68 28, − 8, − 24 − 1.451 < 0.005 Amygdala (BA34)
Hippocampus (BA20)
Median cingulate
 Cerebellum, hemispheric lobule VI R 17 38, − 74, − 20 − 1.392 < 0.005 Cerebellum, hemispheric lobule VI (BA19)
Cerebellum, crus I (BA19)
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