Fig. 5

Excitatory synaptic transmission is decreased in dorsal striatal SPNs of Dlg2^–/– mice. aDlg2 mRNA levels in the mouse brain during development, revealed by in situ hybridization of horizontal sections. Caudate putamen (striatum) regions are delineated by dotted lines on each section. Dlg2 mRNA expression was increased during early development until P7 (see Fig. S1). b Illustration of the dorsolateral striatum region where electrophysiological recordings were made. c, d Representative electrophysiological traces showing spontaneous excitatory postsynaptic currents (sEPSCs, c) and spontaneous inhibitory postsynaptic currents (sIPSCs, d) recorded in spiny projection neurons (SPNs) of the dorsolateral striatum of WT versus Dlg2^–/– mice. e The frequency, but not the amplitude, of sEPSCs was significantly decreased in SPNs of Dlg2^–/– mice compared with that in WT mice (n = 15 neurons from three WT mice and n = 12 neurons from three Dlg2^–/– mice). f Similar frequency and amplitude of sIPSCs in the dorsolateral striatum of Dlg2^–/– mice were found. (n = 17 neurons from three WT and n = 13 neurons from three Dlg2^–/– mice). **p < 0.01; ns, not significant. Student’s t tests were used for e and f