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Fig. 4 | Molecular Autism

Fig. 4

From: A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum

Fig. 4

Dlg2–/– mice display increased self-grooming behavior. Monitoring of behavior in LABORAS cages (home-cage activity) for 72 h showed that both the duration (a) and number (b) of bouts of self-grooming were significantly increased in Dlg2–/– mice compared with WT animals. c, d Increased duration and number of bouts of self-grooming in Dlg2–/– mice were found regardless of light on or off conditions, resulting in significant increases in total duration and number of bouts of self-grooming. WT, n = 10; Dlg2–/–, n = 7. e Measurement of self-grooming behavior in an empty cage without bedding for 10 min showed that Dlg2–/– mice also exhibited a significantly increased duration of self-grooming in this different setting. WT, n = 11; Dlg2–/–, n = 12. Repeated measures of ANOVA was used for a and b, with post hoc Sidak’s multiple comparisons test applied under conditions where there was a significant effect of interaction (noted in a and b). Mann-Whitney tests were used for ce. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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