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Fig. 2 | Molecular Autism

Fig. 2

From: A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum

Fig. 2

Dlg2–/– mice display novelty-induced hypoactivity and moderately increased anxiety-like behavior. a, b In the home-cage–like setting of the LABORAS system, there was no difference in overall locomotion between genotypes, with no main effect of genotype. However, there was a significant interaction effect of time × genotype (“Interaction”), revealing heightened locomotion in Dlg2–/– mice compared to WT mice at 58 h. WT, n = 10; Dlg2–/–, n = 7; repeated measures of two-way ANOVA. c In the open-field test, Dlg2–/– mice showed significantly decreased locomotion compared to WT animals throughout the test duration. Repeated measures two-way ANOVA. In open-field arena and light/dark box tests, Dlg2–/– mice spent significantly less time in the center region of the open-field arena (d) and in the lighted box (e) compared with WT mice. Mann-Whitney test. f In the elevated plus-maze, there was no difference between genotypes in the time spent in open versus closed arms. WT, n = 24; Dlg2–/–, n = 23 for c–f. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant; two-way ANOVA

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Molecular Autism

ISSN: 2040-2392