Table 7 Comparison of results between the main (all subjects) and additional analyses (ASD- discordant and concordant group, and the highest data quality group (High Q)). Significant B-estimates and q values are displayed in bold (q < 0.05) and estimates with a value of q < 0.1 are displayed as regular text. Results are FDR-corrected
Group (n) | Regions associated with RRBI’s on the ADI-R C domain | ||||||
|---|---|---|---|---|---|---|---|
Males Main (88) | Nothing | ||||||
Males ASD Disc (28) ASD Conc (6) | Bilateral Pallidum Increased volume (Left: B = 23.19, q = 0.096; right: B = 31.51, q = 0.096) | ||||||
Males High Q (34) | R. Supramarginal G. Increased area (B = 130.6, q = 0.035) Increased Volume (B = 842.22, q = 0.018) | L. Lateral orbital S. Reduced area (B = − 28.44, q = 0.035) | L. Anterior cingulate C. Increased thickness (B = 0.093, q = 0.001) | ||||
Females Main (62) | R. Intraparietal S. Increased thickness (B = 0.037, q = 0.012) Reduced area (B = − 120.61, q = 0.072) | R. Orbital G. Increased thickness (B = 0.05, q = 0.056) | R. Inferior Frontal Orbital G. Increased thickness (B = 0.07, q = 0.065) | L. Superior Frontal G. Reduced area (B = − 130.44, q = 0.072) | R. Middle Frontal G. Increased area (B = 95.29, q = 0.072) | ||
Females ASD disc (12) ASD Conc (6) | R. Intraparietal S. Increased thickness (B = 0.032, q = 0.013) | R. Orbital G. Increased thickness B = 0.070, q = 0.016) Increased volume (B = 166.73, q = 0.059) | L. Lateral Orbital S. Increased thickness (B = 0.110, q = 0.002) | L. Superior Frontal G. Increased thickness (B = 0.043, q = 0.003) | R. Postcentral G. Increased thickness (B = 0.039, q = 0.087) | L. Postcentral S. Reduced volume (B = − 208.12, q = 0.059) | |
Females High Q (36) | Bi. Intraparietal S. Increased thickness (Left: B = 0.045, q < 0.001; right: B = 0.053, q = 0.027) | L. Lateral orbital S. Increased thickness (B = 0.094, q = 0.002) | L. Inferior frontal orbital G. Increased thickness (B = 0.069, q = 0.022) Increased volume (B = 88.10, q = 0.059) | L. Superior frontal G. Increased thickness (B = 0.059, q < 0.001) Reduced area (B = − 192.15, q = 0.010) | L. Middle frontal G. Increased thickness (B = 0.036, q = 0.031) | R. Postcentral G. Increased thickness (B = 0.038, q = 0.036) Increased volume (B = 235.05, q = 0.053) | R. Postcentral S. Increased thickness (B = 0.038, q < 0.001) |