Table 6 Comparison of results between the main (RRBI’s from the ADI-R C domain) and additional analyses: SRS-2 Autism Mannerisms (AM); ADI-R C + ADI-R reciprocal social interaction (A); and SRS-2 AM + SRS – social cognition (SC)). Significant B-estimates and q values are displayed in bold (q < 0.05) and estimates with a value of q < 0.1 are displayed as regular text. Results are FDR-corrected
Group (n) | Regions associated with RRBI’s on the ADI-R C domain & SRS-2 AM, and when correcting for social cognition symptoms | ||||||
|---|---|---|---|---|---|---|---|
Males ADI-R C (88) | Nothing | ||||||
Males ADIR-C + A | Bilateral cerebellum C. Decreased volume (Right: B = − 1092.29, q = 0.014; Left: B = − 1198.49, q = 0.070) | R. Inferior frontal G. Increased volume (B = 81.99, q = 0.093) | |||||
Males SRS-2 AM | R. Pallidum Increased volume (B = 5.99, q = 0.005) | R. Postcentral S. Reduced volume (B = − 48.93, q = 0.059) Reduced area (B = − 21.74, q = 0.060) | |||||
Males SRS-2 AM + SC | R. Precentral G. Reduced area (B = − 27.92, q = 0.002) | R. Central G. Reduced area (B = − 32.08, q = 0.032) | |||||
Females ADI-R C (62) | R. Intraparietal S. Increased thickness (B = 0.037, q = 0.012) Reduced area (B = − 120.61, q = 0.072) | R. Orbital G. Increased thickness (B = 0.05, q = 0.056) | R. Inferior Frontal Orbital G. Increased thickness (B = 0.07, q = 0.065) | L. Superior Frontal G. Reduced area (B = − 130.44, q = 0.072) | R. Middle Frontal G. Increased area (B = 95.29, q = 0.072) | ||
Females ADIR-C + A | R. Intraparietal S. Increased thickness (B = 0.041, q = 0.008) Reduced area (B = − 115.97, q = 0.075) | R. Orbital G. Increased volume (B = 161.09, q = 0.007) | R. Inferior Frontal Orbital G. Increased thickness (B = 0.075, q = 0.055) | R. Postcentral G. Increased volume (B = 154.48, q = 0.003) | R. Postcentral S. Increased thickness (B = 0.026, q = 0.031) | ||
Females SRS-2 AM (62) | L. Intraparietal S. Increased thickness (B = 0.006, q = 0.049) | R. Orbital G. Increased thickness (B = 0.013, q = 0.008) | L. Lateral Orbital S. Increased thickness (B = 0.017, q = 0.007) | R. Supramarginal G. Increased area (B = 18.69, q = 0.007) | |||
Females SRS-2 AM + SC | L. Angular G. Increased thickness (B = 0.023, q = 0.018) Bi. Angular G. Reduced area (Left: B = − 33.04, q = 0.054; right: B = − 31.05, q = 0.051) | L. Lateral orbital S. Reduced area (B = − 8.13, q = 0.003) | Bi. Middle frontal S. Reduced thickness (Left: B = − 0.009, q = 0.071; right: B = − 0.011, q = 0.067) | R. Supramarginal G. Increased area (B = 33.04, q = 0.063) | R. Superior parietal G. Increased area (B = 26.44, q = 0.066) | R. Superior frontal G. Reduced thickness (B = − 0.009, q = 0.055) | R. Postcentral G. Reduced thickness (B = − 0.017, q = 0.056) |