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Table 5 Twin model associations between subcortical volumes of subcortical regions of interest (ROIs) and RRBI symptoms

From: Sex differences in brain structure: a twin study on restricted and repetitive behaviors in twin pairs with and without autism

ROIs subcorticalVolume males β (SD)
q
Volume females β (SD)
q
ROIs cerebellumVolume males β (SD)
q
Volume females β (SD)
q
Left thalamus proper64.88 27.35Left cerebellum white4.42 64.51
(58.12)(48.61)(160.07)(110.1)
0.6610.7380.9780.5587
Left caudate9.08 55.08Left cerebellum cortex 719.02 256.43
(40.75)(40.32)447.(283.8)
0.9150.7380.2150.559
Left putamen 13.98 13.37Right cerebellum white9.13 85.27
(35.49)(25.49)(101.93)(102.54)
0.9150.7380.9780.559
Left pallidum19.66 5.64Right cerebellum cortex 664.7 282.66
(9.52)(12.84)(294.83)(341.24)
0.1940.7380.1050.559
Left amygdala0.078.96Somato motor18.747.23
(9.5)(24.15)(8.89)(12.37)
0.9940.7380.1050.559
Right thalamus proper25.28 31.66Somato motor white11.768.33
(37.31)(32.66)(10.92)(12.29)
0.8300.7380.4220.559
Right caudate 37.03 36.45   
(47.76)(39.31)   
0.8300.738   
Right putamen62.72 23.84   
(45.87)(22.52)   
0.5720.738   
Right pallidum29.47 6.45   
(13.06)(19.29)   
0.1940.738   
Right amygdala4.99 13.25   
(19.11)(16.92)   
0.9150.738   
  1. Estimates (B), standard deviations (SD), and q values (q) for the within-pair associations between all surface-based subcortical volumes and repetitive behavior symptoms, as assessed by the ADI-R C. For the whole group associations, sex was added as a covariate. A positive estimate indicates an increase in brain estimate related to more repetitive behavior symptoms. Bold text indicates significant associations (FDR-corrected q value < 0.05), while bold and grey text indicate associations with q value < 0.10 (FDR-corrected)